NC |
1 |
Slight reduction until complete normalization in 72 hours |
Slight depression until complete normalization in 72 hours |
Practically normal after recovery from anesthesia in the postoperative period |
No spasticity |
- |
2 |
- |
3 |
- |
4 |
Died on the first postoperative day |
5 |
- |
6 |
- |
7 |
- |
8 |
- |
PC |
1 |
Slight reduction until complete normalization in 72 hours |
Slight depression until complete normalization in 72 hours |
Practically normal after recovery from anesthesia in the postoperative period |
No spasticity |
- |
2 |
- |
3 |
- |
4 |
- |
5 |
- |
6 |
- |
7 |
- |
8 |
- |
UTM |
1 |
Difficulty feeding independently |
Depression of mental state with impact on mobility capacity |
Rat without mobility, moving only limbs and lying down |
With spasticity in right limbs |
Died on the second postoperative day |
2 |
Slight reduction until complete normalization in 72 hours |
Slight depression until complete normalization in 72 hours |
Rat can walk and move, but with instability and misalignment |
Spasticity in the left limbs, especially upper limb |
- |
3 |
Slight reduction to complete normalization in 72 hours |
Slight depression to complete normalization in 72 hours |
Practically normal after recovery from anesthesia in the postoperative period |
No spasticity |
- |
4 |
Difficulty feeding independently |
Depression of mental state with reflexes on mobility capacity |
Rat became very weak, with little mobility, practically only moving its limbs without being able to assume a supportive posture, remaining lying down. He was only able to crawl for a short distance when he had some support (wall). Unable to stand on the Rotarod or cross the CatWalk |
With spasticity in all four limbs |
Died on the 14th postoperative day |
5 |
Difficulty feeding independently |
Depression of mental state with impact on ability to move |
Mouse without mobility, moving only the limbs and lying down |
With spasticity in all four limbs |
Died on the third postoperative day |
UTM |
6 |
Difficulty feeding independently |
Depression of mental state reflected in ability to move |
Rat without mobility, moving only its limbs, but with little range of movement. Only lying down |
With spasticity in all four limbs |
Died on the second postoperative day |
7 |
Difficulty feeding independently |
Depressed mental state with impact on ability to move |
Poor mobility, turning on its own vertical axis when trying to move |
Spasticity in all four limbs, especially upper limbs |
Died on the fourth postoperative day |
8 |
- |
- |
- |
- |
Died during surgery |
TM |
1 |
Unable to feed himself |
Depression of mental state with impact on ability to move |
Moved in a circle and very unstable in different postures |
With spasticity in the right limbs |
Died in the first postoperative day |
2 |
Slight reduction to complete normalization in 72 hours |
Slight depression to complete normalization in 72 hours |
Practically normal after recovery from anesthesia in the postoperative period |
No spasticity |
- |
3 |
Slight reduction until complete normalization in 72 hours |
Slight depression until complete normalization in 72 hours |
Rat can walk and move, but with instability and misalignment. |
Mild spasticity in the lower limb |
- |
4 |
Difficulty feeding independently |
Depression of mental state with impact on ability to move |
Rat with little mobility, remaining lying down |
With spasticity in right limbs, mainly in upper limb |
Died on the second postoperative day |
5 |
Difficulty feeding independently |
Depressed mental state with impact on ability to move |
Rat, when trying to move, rolled on its own vertical axis without being able to ambulate |
With spasticity in all four limbs |
Died on the third day |
6 |
Difficulty feeding independently, even after 72 hours of postoperative |
Depressed mental state with impact on ability to move |
Rat became very weak, with little mobility, practically only moving its limbs without being able to assume a supportive posture, remaining lying down. He only manages to crawl a short distance when he had some support (a wall). Unable to stand on the Rotarod or cross the CatWalk |
Spasticity in the right limbs, especially in the lower limb |
Died on the tenth postoperative day |
7 |
Difficulty eating independently |
Depressed mental state with an impact on mobility |
Poor mobility, lying down and basically moving his limbs |
Spasticity in the right limbs, more pronounced in the upper limb. Presence of spasms in the left upper limb. |
Died on the third postoperative day |
8 |
Slight reduction until complete normalization in 72 hours |
Slight depression until complete normalization in 72 hours |
Practically normal after recovery from anesthesia in the postoperative period |
No spasticity |
- |