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Quantitative research into the skeletal muscle tissue of rats in endurance training inducing neovascularization in the ischemic skeletal muscle

PURPOSE: This work introduces quantitative research into the skeletal muscle tissue of rats, suffering induced outlying arterial inadequacy after endurance training. METHODS: All those rats had been prepared surgically towards the right femoral artery total occlusion. After surgical procedures, the rats were either restricted to activities inside their cage (sedentary ones, n=10) or undergone endurance training with cycle ergometer in continuous way (trained ones, n=10), which consisted in walking twice a day (morning and afternoon) at 17m/min, for 5 minutes, 5 days a week during 8 and 12 weeks. The groups were halved in order with their respective sedentary groups. The analysis was achieved by vast medial muscle histological observation after test period. RESULTS: Considering the eight-week trained group, the average number of muscle tissue capillary vessels has been shown higher (5,2 ± 3,834) than in the sedentary one (0,6 ± 0,894). Also in the 12-week trained group, the average number of capillary vessels has been shown higher (6,8 ± 3,033) than in the sedentary one (3,0 ± 2,345). The average number of capillary vessels between the 12-week and 8-week groups has been shown higher in the first group as well, however, not statistically significant. The average number of the 12-week sedentary group's capillary vessels has been higher (3,0 ± 2,345) than the eight-week one's (0,6 ± 0,894). CONCLUSION: The muscle adaptive process concerning the capillary vessels' increasing number through the endurance training of rats, which have induced outlying arterial inadequacy.

Neovascularization; Skeletal muscle; Endurance training


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