The use of medicinal plants is a commonly practice observed at developing countries. Then, this paper aim to verify the effect of the copaiba oil in the liver of rats. Fifty male Wistar rats were used distributed into five groups: Group Copaiba 0.63 (GC0.63 ml/kg of copaiba oil), Group Copaiba 0.06 (GC0.06 ml/kg of copaiba oil), Group Water (GA0.63 ml/kg of water), Group Corn Oil (GM0.63 ml/kg of corn oil) and Standard group (GP). The substances were administered daily by 14 days. The animals were submitted to euthanasia in the 14th day, being withdraw the liver and realized histologic study. The results demonstrated that microscopically, in the hepatocity cells no alterations were found; however, vascular congestion was verified in the portal and mid-lobular veins. A larger congestion was observed in the group GC0.63 in relation to the groups GC0.06, GM, GA and GP (p <0.05). Although, the group GC0.06 has presented larger vascular congestion in relation to the groups GM, GA and GP but without significance statistical (p> 0.05), suggesting a dose-effect relationship. Then, the authors conclude that in agreement with methodology used, the copaiba oil promote vascular congestion in the liver of rats, suggesting dose-dependent action.
Plants; medicinal; Liver; Histology; Rats
