Perineural invasion |
1515 Ko JJ, Siever JE, Hao D, Simpson R, Lau HY. Adenoid cystic carcinoma of head and neck: clinical predictors of outcome from a Canadian centre. Curr Oncol. 2016;23(1):26-33. PMid:26966401. http://doi.org/10.3747/co.23.2898. http://doi.org/10.3747/co.23.2898...
/n=60 |
Margin status and perineural invasion predict disease-free survival or overall survival |
1616 Gomez DR, Hoppe BS, Wolden SL, et al. Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. Int J Radiat Oncol Biol Phys. 2008;70(5):1365-72. PMid:18029108. http://doi.org/10.1016/j.ijrobp.2007.08.008. http://doi.org/10.1016/j.ijrobp.2007.08....
/n=59 |
Although clinical T stage, gross nerve invasion, and nodal involvement before treatment were adverse prognostic factors, routine radiation of the skull base may reduce the bad prognostic significance of the perineural invasion |
1717 Gurney TA, Eisele DW, Weinberg V, Shin E, Lee N. Adenoid cystic carcinoma of the major salivary glands treated with surgery and radiation. Laryngoscope. 2005;115(7):1278-82. PMid:15995521. http://doi.org/10.1097/01.MLG.0000165381.64157.AD. http://doi.org/10.1097/01.MLG.0000165381...
/n=33 |
Perineural invasion did not demonstrate a statistically significant association with survival. |
1818 Garden AS, Weber RS, Morrison WH, Ang KK, Peters LJ. The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation. Int J Radiat Oncol Biol Phys. 1995;32(3):619-26. PMid:7790247. http://doi.org/10.1016/0360-3016(95)00122-F. http://doi.org/10.1016/0360-3016(95)0012...
/n=198 |
Perineural invasion was an adverse prognostic factor only when a major nerve was involved. |
1919 Ramsden D, Sheridan BF, Newton NC, De Wilde FW. Adenoid cystic carcinoma of the head and neck: a report of 30 cases. Aust N Z J Surg. 1973;43(2):102-8. PMid:4376685. http://doi.org/10.1111/j.1445-2197.1973.tb07319.x. http://doi.org/10.1111/j.1445-2197.1973....
/n=30 |
Need to do a frozen section examination of the peripheral margins along with the adjacent nerve that is most likely involved. |
2222 Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Hinerman RW, Villaret DB. Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck. Head Neck. 2004;26(2):154-62. PMid:14762884. http://doi.org/10.1002/hed.10380. http://doi.org/10.1002/hed.10380...
and 2020 Kokemüller H, Eckardt A, Brachvogel P, Hausamen JE. Adenoid cystic carcinoma of the major and minor salivary glands. Retrospective analysis of 74 patients. Mund Kiefer Gesichtschir. 2003;7(2):94-101. PMid:12664254., |
perineural or clinically named nerve invasion alarms for a worse prognosis |
2121 Sur RK, Donde B, Levin V, et al. Adenoid cystic carcinoma of the salivary glands: a review of 10 years. Laryngoscope. 1997;107(9):1276-80. PMid:9292617. http://doi.org/10.1097/00005537-199709000-00022. http://doi.org/10.1097/00005537-19970900...
|
Perineural involvement does not impact outcome. |
Perivascular invasion |
1717 Gurney TA, Eisele DW, Weinberg V, Shin E, Lee N. Adenoid cystic carcinoma of the major salivary glands treated with surgery and radiation. Laryngoscope. 2005;115(7):1278-82. PMid:15995521. http://doi.org/10.1097/01.MLG.0000165381.64157.AD. http://doi.org/10.1097/01.MLG.0000165381...
/n=33 |
5 cases of Perivascular invasion (No mention of its significance) |
Other tissue invasion |
1717 Gurney TA, Eisele DW, Weinberg V, Shin E, Lee N. Adenoid cystic carcinoma of the major salivary glands treated with surgery and radiation. Laryngoscope. 2005;115(7):1278-82. PMid:15995521. http://doi.org/10.1097/01.MLG.0000165381.64157.AD. http://doi.org/10.1097/01.MLG.0000165381...
/n=33 |
15 cases of muscle or tissue invasion (No mention of its significance) |