Sinonasal Undifferentiated Carcinoma (SNUC) |
30-77 years; nasal cavity and maxillary sinus; Aggressive uncommon |
Undifferentiated without any squamous, glandular or rhabdoid differentiation77 Jeng YM, Sung MT, Fang CL, et al. Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities. Am J Surg Pathol. 2002;26(3):371-6. http://dx.doi.org/10.1097/00000478-200203000-00012. PMid:11859210. http://dx.doi.org/10.1097/00000478-20020...
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IDH2 codon R172 mutation1111 Agaimy A, Franchi A, Lund VJ, et al. Sinonasal undifferentiated carcinoma (SNUC): from an entity to morphologic pattern and back again-a historical perspective. Adv Anat Pathol. 2020;27(2):51-60. http://dx.doi.org/10.1097/PAP.0000000000000258. PMid:31876536. http://dx.doi.org/10.1097/PAP.0000000000...
,1212 Weindorf SC, Brown NA, McHugh JB, Udager AM. Sinonasal papillomas and carcinomas: a contemporary update with review of an emerging molecular classification. Arch Pathol Lab Med. 2019;143(11):1304-16. http://dx.doi.org/10.5858/arpa.2019-0372-RA. PMid:31661314. http://dx.doi.org/10.5858/arpa.2019-0372...
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NUT- carcinoma |
26-48 years; Sinuses. Aggressive tumors |
Undifferentiated with a squamous differentiation |
NUTM1 gene re-arrangement1212 Weindorf SC, Brown NA, McHugh JB, Udager AM. Sinonasal papillomas and carcinomas: a contemporary update with review of an emerging molecular classification. Arch Pathol Lab Med. 2019;143(11):1304-16. http://dx.doi.org/10.5858/arpa.2019-0372-RA. PMid:31661314. http://dx.doi.org/10.5858/arpa.2019-0372...
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Sinonasal adenocarcinoma |
Aggressive tumors |
Enteric and mucinous subtype |
MAPK mutations and ETV6 gene rearrangements1212 Weindorf SC, Brown NA, McHugh JB, Udager AM. Sinonasal papillomas and carcinomas: a contemporary update with review of an emerging molecular classification. Arch Pathol Lab Med. 2019;143(11):1304-16. http://dx.doi.org/10.5858/arpa.2019-0372-RA. PMid:31661314. http://dx.doi.org/10.5858/arpa.2019-0372...
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SMARCB1 deficient tumors |
19-89 years; sinuses, mainly ethmoid. Aggressive tumors |
Plasmacytoid and rhabdoid |
loss of INI-11212 Weindorf SC, Brown NA, McHugh JB, Udager AM. Sinonasal papillomas and carcinomas: a contemporary update with review of an emerging molecular classification. Arch Pathol Lab Med. 2019;143(11):1304-16. http://dx.doi.org/10.5858/arpa.2019-0372-RA. PMid:31661314. http://dx.doi.org/10.5858/arpa.2019-0372...
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SMARCA4deficient carcinomas |
20-67 years; mainly nasal cavity; Aggressive tumors |
Poorly differentiated |
SMARCA4 deficient1313 Agaimy A, Weichert W. SMARCA4-deficient sinonasal carcinoma. Head Neck Pathol. 2017;11(4):541-5. http://dx.doi.org/10.1007/s12105-017-0783-4. PMid:28176137. http://dx.doi.org/10.1007/s12105-017-078...
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Sinonasal squamous cell carcinoma |
Most common |
Keratinizing, non-keratinizing, adenosquamous basaloid. |
HPV subtypes expression, KRAS, and EGFR mutations1212 Weindorf SC, Brown NA, McHugh JB, Udager AM. Sinonasal papillomas and carcinomas: a contemporary update with review of an emerging molecular classification. Arch Pathol Lab Med. 2019;143(11):1304-16. http://dx.doi.org/10.5858/arpa.2019-0372-RA. PMid:31661314. http://dx.doi.org/10.5858/arpa.2019-0372...
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