Kumar et al.1515 Kumar K, Shetty DC, Wadhwan V, Gupta P. Synchronous oral squamous cell carcinomas with unusual histopathological feature. J Oral Maxillofac Pathol. 2012;16(3):420-4. http://dx.doi.org/10.4103/0973-029X.102506. PMid:23248478. http://dx.doi.org/10.4103/0973-029X.1025...
|
70/ F |
Lobulated growth 1: Maxillary anterior region in between central incisors Lobulated growth 2: Edentulous area of mandibular right first molar |
Pan chewing with areca nut, lime, and tobacco |
Positive – EMA, CK8, CK18 |
Negative – PAS, Mucicarmine |
Died within 2 months |
Negative – Vimentin, S-100, HMB 45 |
Frazier et al.1111 Frazier JJ, Sacks H, Freedman PD. Primary glycogen-rich clear cell squamous cell carcinoma of the mandibular gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(5):e47-51. http://dx.doi.org/10.1016/j.oooo.2012.01.033. PMid:23083485. http://dx.doi.org/10.1016/j.oooo.2012.01...
|
59/ F |
Exophytic lesion on the left mandibular gingiva extending from the buccal vestibule to floor of the mouth; Unhealed extraction socket |
– |
– |
Positive – PAS |
Lost to follow-up |
Negative – PAS diastase, Mucicarmine |
Nainani et al.1616 Nainani P, Singh HP, Paliwal A, Nagpal N. A rare case report of clear cell variant of oral squamous cell carcinoma. J Clin Diagn Res. 2014;8(12):QD07-09. http://dx.doi.org/10.7860/JCDR/2014/11536.5339. PMid:25654003. http://dx.doi.org/10.7860/JCDR/2014/1153...
|
52/ M |
Irregular diffuse erythematous ulcero-proliferative growth on the left side of buccal mucosa. |
No tobacco/ alcohol history |
Positive – CK8, CK18 |
Negative – PAS, Mucicarmine, Oil red O |
Died within 3 months |
Negative – Vimentin, S-100 |
Romañach et al.1717 Romañach M, Canedo N, Cortezzi E, Abrahão A, Cabral M, Agostini M. Clear cell variant of oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(6):e195. http://dx.doi.org/10.1016/j.oooo.2014.05.102. http://dx.doi.org/10.1016/j.oooo.2014.05...
|
60/ F |
Ulcerated swelling in the posterior buccal mucosa extending to the soft palate. |
– |
Positive – CKAE1/AE3, p63 |
Positive – PAS |
No recurrence after 12 months of surgery |
Negative – Vimentin, CD10 |
Kaliamoorthy et al.55 Kaliamoorthy S, Sethuraman V, Ramalingam SM, Arunkumar S. A rare case of clear cell variant of oral squamous cell carcinoma. J Nat Sci Biol Med. 2015;6(1):245-7. http://dx.doi.org/10.4103/0976-9668.149209. PMid:25810675. http://dx.doi.org/10.4103/0976-9668.1492...
|
35/ F |
Non-healing ulcer involving left posterior lateral border of the tongue and lingual vestibule |
No tobacco/ alcohol history |
Positive – CK AE1/ AE3 |
Negative – PAS, Mucicarmine |
– |
Negative – Vimentin, EMA, HMB 45. |
Devi et al.1818 Devi A, Kamboj M, Singh V, Singh S. Clear-cell variant of squamous cell carcinoma in maxilla as primary lesion: a rare case. J Oral Maxillofac Pathol. 2017;21(3):425-8. http://dx.doi.org/10.4103/jomfp.JOMFP_180_16. PMid:29391719. http://dx.doi.org/10.4103/jomfp.JOMFP_18...
|
55/ M |
an ulcerated swelling on Left posterior region of maxilla |
– |
Positive – CK, EMA |
Negative – PAS, Mucicarmine |
– |
Negative – S-100, Vimentin |
Khoury et al.1919 Khoury ZH, Bugshan A, Lubek JE, Papadimitriou JC, Basile JR, Younis RH. Glycogen-rich clear cell squamous cell carcinoma originating in the oral cavity. Head Neck Pathol. 2017;11(4):552-60. http://dx.doi.org/10.1007/s12105-017-0812-3. PMid:28342060. http://dx.doi.org/10.1007/s12105-017-081...
|
66/ F |
Ulcerative mass of the left lateral tongue extending anteriorly to the floor of the mouth |
– |
Positive – Pancytokeratin, CK5/6, and p63 |
Positive – PAS |
3 months after surgery, metastasis to left lung |
Negative − S-100, Calponin, SMA |
Kakoti et al.1010 Kakoti LM, Mahanta D, Sharma JD, Chowdhury Z. Clear-cell squamous cell carcinoma: an uncommon variant of very common malignancy in the head and neck. Int J Oral Health Sci. 2018;8(2):136-9. http://dx.doi.org/10.4103/ijohs.ijohs_23_18. http://dx.doi.org/10.4103/ijohs.ijohs_23...
|
59/ M |
Exophytic growth in the right upper jaw |
– |
Positive – CK |
Negative – PAS |
– |
Negative – S-100, EMA |
Ramani et al.1212 Ramani P, Gheena S, Karunagaran M, Hannah R. Clear-cell variant of oral squamous cell carcinoma: a rare entity. J Oral Maxillofac Pathol. 2021;25(4, Suppl. 1):S22-6. http://dx.doi.org/10.4103/jomfp.JOMFP_295_20. PMid:34083965. http://dx.doi.org/10.4103/jomfp.JOMFP_29...
|
42/ F |
a soft-tissue growth with erythematous and non-scrapable irregular white patches on the left alveolar mucosa in relation to 35, 36, and 37 |
– |
Positive – CK |
Negative – PAS, Mucicarmine |
Lost to follow-up |
Negative – S-100, EMA, SMA, CD 117 |
Index case |
60/ M |
Non-healing ulcer on posterolateral border of tongue |
Tobacco chewing |
Positive – CK |
Positive – PAS diastase |
Lost to follow-up |
Negative – Mucicarmine |