rs1234315 (T allele)
|
|
|
|
|
|
|
|
|
Han et al. [ 1717. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 2009;41(11):1234–7. ] |
China |
Asian |
4,199 |
8,255 |
0.503 |
0.421 |
1.37 (1.29-1.45) |
2.3 × 10−26
|
Zhang et al. [ 1414. Zhang SQ, Han JW, Sun LD, Lu WS, Yin XY, Zhang XJ, et al. A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population. Rheumatol Int. 2011;31(2):227–31. ] |
China |
Asian |
1,344 |
4,315 |
0.512 |
0.395 |
1.45 (1.34-1.60) |
1.5 × 10−16
|
Yang et al. [ 1818. Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, Qian XX, et al. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet. 2010;6(2):e1000841. ] |
China |
Asian |
3,300 |
4,200 |
0.539 |
0.468 |
1.33 |
1.0 × 10−3
|
Xu et al. [ 11. Xu J, He Y, Wang J, Li X, Huang L, Li S, et al. Influence of the TNFSF4 rs1234315 polymorphism in the susceptibility to systemic lupus erythematosus and rheumatoid arthritis. Hum Immunol. 2019;80(4):270–5. https://doi.org/10.1016/j.humimm.2018.11.006. https://doi.org/10.1016/j.humimm.2018.11...
] |
China |
Asian |
294 |
282 |
0.531 |
0.434 |
1.47 (1.17-1.86) |
0.001 |
Chang et al. [ 1919. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun. 2009;10(5):414–20. ] |
China |
Asian |
314 |
920 |
0.538 |
0.445 |
1.46 (1.21-1.75) |
4. 9 × 10−5
|
rs844648 (A allele)
|
|
|
|
|
|
|
|
|
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Germany |
European |
259 |
322 |
0.470 |
0.400 |
1.29 (1.02-1.63) |
3.3 × 10−2
|
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Italy |
European |
258 |
223 |
0.430 |
0.350 |
1.40 (1.08-1.82) |
1.1 × 10−2
|
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Spain, |
European |
517 |
901 |
0.420 |
0.440 |
0.94 (0.80-1.10) |
0.407 |
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Argentina |
Latin American |
278 |
355 |
0.440 |
0.520 |
0.73 (0.58-0.91) |
3.9 × 10−3
|
Chang et al. [ 1919. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun. 2009;10(5):414–20. ] |
Chinese |
Asian |
314 |
920 |
0.546 |
0.465 |
1.39 (1.16-1.66) |
4.2 × 10−4
|
rs2205960 (T allele)
|
|
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|
|
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|
|
V Gupta et al. [ 2121. Gupta V, Kumar S, Pratap A, Singh R, Kumari R, Kumar S, et al. Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population. Lupus. 2018;27(12):1973–9. ] |
India |
Asian |
394 |
583 |
0.277 |
0.225 |
1.32 (1.07-1.63) |
< 0.01 |
Zhou et al. [ 1313. Zhou XJ, Lu XL, Nath SK, Lv JC, Zhu SN, Yang HZ, et al. Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum. 2012;64(1):222–31. ] |
China |
Asian |
722 |
804 |
0.345 |
0.274 |
1.39 (1.19-1.62) |
2.8 × 10−5
|
Sanchez et al. [ 2222. Sanchez E, Webb RD, Rasmussen A, Kelly JA, Riba L, Kaufman KM, et al. Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. Arthritis Rheum. 2010;62(12):3722–9. ] |
USA |
African-American |
767 |
640 |
0.370 |
0.289 |
1.49 (1.27-1.75) |
1.7 × 10−6
|
Sanchez et al. [ 2323. Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, et al. Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum. 2011;63(11):3493–501. ] |
USA |
African-American |
2839 |
3441 |
0.070 |
0.049 |
1.44 (1.17-1.76) |
5.6 × 10−4
|
Han et al. [ 1717. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 2009;41(11):1234–7. ] |
China |
Asian |
4,199 |
8,255 |
0.347 |
0.268 |
1.46 (1.37-1.56) |
2.5 × 10−32
|
Gupta et al. [ 2121. Gupta V, Kumar S, Pratap A, Singh R, Kumari R, Kumar S, et al. Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population. Lupus. 2018;27(12):1973–9. ] |
Indian |
Asian |
394 |
583 |
0.225 |
0.277 |
1.32 (1.07-1.63) |
< 0.01 |
Chua et al. [ 88. Chua KH, Ooh YY, Chai HC. TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population. Int J Immunogenet. 2016;43(5):303–9. ] |
Chinese |
Asian |
198 |
178 |
0.298 |
0.248 |
1.27 (1.00-1.61) |
0.05 |
Chua et al. [ 88. Chua KH, Ooh YY, Chai HC. TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population. Int J Immunogenet. 2016;43(5):303–9. ] |
Malay |
Asian |
42 |
43 |
0.193 |
0.189 |
1.03 (0.64-1.65) |
0.91 |
Chua et al. [ 88. Chua KH, Ooh YY, Chai HC. TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population. Int J Immunogenet. 2016;43(5):303–9. ] |
Indian |
Asian |
24 |
12 |
0.387 |
0.167 |
3.16 (1.41-7.05) |
0.004 |
Chang et al. [ 1919. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun. 2009;10(5):414–20. ] |
Chinese |
Asian |
314 |
920 |
0.331 |
0.227 |
1.69 (1.39-2.06) |
1.95 × 10−7
|
rs704840 (G allele)
|
|
|
|
|
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|
|
Chua et al. [ 88. Chua KH, Ooh YY, Chai HC. TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population. Int J Immunogenet. 2016;43(5):303–9. ] |
Chinese |
Asian |
303 |
283 |
0.451 |
0.394 |
12.6 (1.02-1.56) |
0.03 |
Chua et al. [ 88. Chua KH, Ooh YY, Chai HC. TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population. Int J Immunogenet. 2016;43(5):303–9. ] |
Malay |
Asian |
77 |
82 |
0.353 |
0.360 |
0.97 (0.67-1.44) |
0.89 |
Chua et al. [ 88. Chua KH, Ooh YY, Chai HC. TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population. Int J Immunogenet. 2016;43(5):303–9. ] |
Indian |
Asian |
23 |
22 |
0.371 |
0.306 |
1.34 (0.65-2.75) |
0.42 |
Chang et al. [ 1919. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun. 2009;10(5):414–20. ] |
Chinese |
Asian |
314 |
920 |
0.490 |
0.390 |
1.51 (1.25-1.81) |
1.06 × 10−5
|
Yang et al. [ 1818. Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, Qian XX, et al. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet. 2010;6(2):e1000841. ] |
China |
Asian |
3,300 |
4,200 |
0.491 |
0.420 |
1.33 |
1.21 × 10−3
|
rs844644 (A allele)
|
|
|
|
|
|
|
|
|
Chang et al. [ 1919. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun. 2009;10(5):414–20. ] |
Chinese |
Asian |
314 |
920 |
0.545 |
0.458 |
1.41 (1.18-1.70) |
1.82 × 10−4
|
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Germany |
European |
259 |
322 |
0.440 |
0.450 |
0.97 (0.76-1.22) |
0.7691 |
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Italy |
European |
258 |
223 |
0.390 |
0.500 |
0.64 (0.49-0.82) |
5.68 × 10−4
|
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Spain, |
European |
517 |
901 |
0.460 |
0.450 |
1.04 (0.89-1.21) |
0.6064 |
Delgado Vega et al. [ 2020. Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, et al. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009;10(3):248–53. ] |
Argentina |
Latin American |
278 |
355 |
0.350 |
0.440 |
0.69 (0.55-0.87) |
1.59 × 10−3
|
rs10489265 (G allele)
|
|
|
|
|
|
|
|
|
Zhou et al. [ 1313. Zhou XJ, Lu XL, Nath SK, Lv JC, Zhu SN, Yang HZ, et al. Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum. 2012;64(1):222–31. ] |
China |
Asian |
722 |
804 |
0.348 |
0.287 |
1.33 (1.14-1.55) |
3.10 × 10−4
|
Orozco et al. [ 2424. Orozco G, Eyre S, Hinks A, Bowes J, Morgan AW, Wilson AG, et al. Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 2011;70(3):463–8. ] |
UK |
European |
3962 |
9275 |
0.250 |
0.240 |
1.05 (0.99-1.12) |
0.11 |