Ikenouchi- Sugita et al. [2626 Ikenouchi-Sugita A, Yoshimura R, Okamoto T, Umene-Nakano W, Ueda N, Hori H, et al. Serum brain-derived neurotrophic factor levels as a novel biological marker for the activities of psychiatric symptoms in systemic lupus erythematosus. World J Biol Psychiatry. 2010;11(2):121-8.] |
Japan |
Cross-sectional |
Emax Immuno- assey Kit (Promega, Madison, WI, USA) |
Serum |
54 |
ACR |
40.10 ± 1.98 |
49/5 |
15,984.4 ± 11,820.8 |
28 |
40.4 ± 2.08 |
25/3 |
11,440 ± 690 |
BDNF |
Serum BDNF levels were significantly increased in the NP group |
Fauchais et al. [2727 Fauchais A-L, Lise M-C, Marget P, Lapeybie F-X, Bezanahary H, Martel C, et al. Serum and lymphocytic neurotrophins profiles in systemic lupus erythematosus: a case-control study. PLoS ONE. 2013;8(11): e79414.] |
France |
Cross-sectional |
ELISA Kits |
Serum |
26 |
ACR |
44 ± 12 |
24/2 |
598.9 ± 129.8 |
26 |
|
24/2 |
326.10 ± 60.50 |
BDNF NGF NT3 CH50 Anti-nuclear Ab/nDNA |
They have demonstrated that both NGF and BDNF serum levels are higher in SLE patients than healthy controls |
Tamashiro et al. [2828 Tamashiro LF, Oliveira RD, Oliveira R, Frota ERC, Donadi EA, Del-Ben CM, et al. Participation of the neutrophin brain-derived neurotrophic factor in neuropsychiatric systemic lupus erythematosus. Rheumatology. 2014;53(12):2182-90.] |
Brazil |
Cross-sectional + Longitudinal stage |
ELISA (R&D Systems, Minneapolis, MN, USA) |
Plasma |
131 |
ACR |
32.78 ± 12.36 |
120/11 |
3870.8066 ± 4793.3575 |
24 |
33 ± 9 |
15/9 |
2205.4269 ± 2938.6665 |
BDNF ANA aPL Anti-ribosomal P protein Anti-dsDNA C3, C4 |
BDNF levels were increased in inactive NPSLE when compared with active SLE and controls |
Zheng et al. [3030 Zheng Q, Xu M-J, Cheng J, Chen J-M, Zheng L, Li Z-G. Serum levels of brain-derived neurotrophic factor are associated with depressive symptoms in patients with systemic lupus erythematosus. Psychoneuroendo-crinology. 2017;78:246-52.] |
China |
Cross-sectional |
ELISA (R&D Systems, Minneapolis, MN, USA) |
Serum |
208 |
SDI score, SLEDAI-2 K score, VAS score |
55.70 ± 10.45 |
190/18 |
33,654.3 ± 9032.9 |
100 |
55.70 ± 10.53 |
0/0 |
14,694.4 ± 4438 |
BDNF EGFR Anti-dsDNA ANA Anti-sm antibody CRP C3 C4 |
The serum BDNF levels were significantly higher in SLE patients as compared to normal controls The serum BDNF levels were significantly lower in depression patients at the time of admission as compared with patients without depression |
Kalinowska-Łyszczarz et al. [2929 Kalinowska-Łyszczarz A, Pawlak MA, Wyciszkiewicz A, Pawlak-Buś K, Leszczyński P, Puszczewicz M, et al. Immune cell neurotrophin production is associated with subcortical brain atrophy in neuropsychiatric systemic lupus erythematosus patients. NeuroImmunoModulation. 2017;24(6):320-30.] |
Poland |
Cohort |
ELISA Kits (Multi- Neurotrophin Rapid Screening ELISA Kit) |
Serum |
38 (BDNF was detected in 33 patients) |
ACR |
40 ± 12 |
36/2 |
424.8199 ± 676.239 |
39 BDNF was detected in 38 patients) |
|
|
1766.9266 ± 1161.4063 |
BDNF NGF NT3 NT4/5 |
BDNF levels were reduced in NPSLE compared to the healthy population |
Noris-GarCia et al. [3232 Noris-García E, Arce S, Nardin P, Lanigan M, Acuña V, Gutierrez F, et al. Peripheral levels of brain-derived neurotrophic factor and S100B in neu-ropsychiatric systemic lupus erythematous. Lupus. 2018;27(13):2041-9.] |
Cuba |
Cross-sectional |
ELISA Kit (BDNF ELISA, Promega, Charbonnieres, France) |
Serum |
47 |
ACR-97 |
47 ± 11 |
45/2 |
4210 ± 1783.4 |
20 |
47 ± 13 |
16/4 |
4494 ± 1739.3 |
BDNF S100B ANA Anti-dsDNA Anti-cardiolipin antibodies, Anti-neutrophil cytoplasmic antibodies |
BDNF levels were significantly decreased in active SLE, when compared with inactive SLE |
Tian et al. [3333 Tian B, Yang C, Wang J, Hou X, Zhao S, Li Y, et al. Peripheral blood brain-derived neurotrophic factor level and tyrosine kinase B expression on T lymphocytes in systemic lupus erythematosus: Implications for systemic involvement. Cytokine. 2019;123: 154764.] |
China |
Cross-sectional |
ELISA (DBNT00, R&D Systems, Minneapolis, USA) |
Serum |
50 |
ACR |
31.9 ± 14.9 |
45/5 |
14,742.5 ± 7620.9 |
30 |
|
|
33,116.5 ± 7146.5 |
BDNF TrkB expression |
Serum BDNF levels in SLE patient were decreased when compared to the controls BDNF level was increased in inactive SLE group compared to the active SLE group |
Alessi et al. [3131 Alessi H, Dutra LA, Maria LA, Coube PC, Hoshino K, de Abrantes FF, et al. Serum BDNF and cognitive dysfunction in SLE: findings from a cohort of 111 patients. Clin Rheumatol. 2022;41(2):421-8.] |
Brazil |
Cross-sectional |
ELISA (Norcross, GA, USA) |
Serum |
111 |
SLICC |
38.28 ± 10.64 |
102/9 |
788,651.4 ± 458,815.5 |
57 |
41.6 ± 11.1 |
48/9 |
1,345,500 ± 438,400 |
BDNF Anti-sm antibodies, ANA, Anti-LA/SSB Anti-Ro/SSA Anti-P Anti-DNA Anti-RNP |
Serum BDNF levels were lower in SLE and NPSLE patients than control group |