Risk
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Chang [3333 Zeng C, Fang C, Weng H, Xu X, Wu T, Li W. B-cell lymphocyte kinase polymorphisms rs13277113, rs2736340, and rs4840568 and risk of autoimmune diseases: a meta-analysis. Medicine. 2017;96:e7855. https://doi.org/10.1097/MD.0000000000007855. https://doi.org/10.1097/MD.0000000000007...
] |
BLK, rs4840568 |
A versus G: OR = 1.32, 95% CI = 1.22-1.43, P = 0.010 |
Song [3434 Song GG, Lee YH. Association between BLK polymorphisms and susceptibility to SLE: a meta-analysis. Z Rheumatol. 2017;76:176-82. https://doi.org/10.1007/s00393-016-0072-8. https://doi.org/10.1007/s00393-016-0072-...
] |
BLK, rs13277113 |
A allele: OR = 1.36, 95% CI = 1.29-1.43, P < 0.001 |
Xiong [3131 Xiong J, He Z, Zeng X, Zhang Y, Hu Z. Association of Vitamin D receptor gene polymorphisms with systemic lupus erythematosus: a meta-analysis. Clin Exp Rheumatol. 2014;32:174-81.] |
VDR BsmI, rs1544410 |
BB + Bb versus bb: OR = 2.14, 95% CI = 1.20-3.82, P = 0.010 |
Lee [3939 Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet. 2006;14:364-71. https://doi.org/10.1038/sj.ejhg.5201566. https://doi.org/10.1038/sj.ejhg.5201566...
] |
TNF-α promoter-308 A/G |
A/A: OR = 3.2, 95% CI = 2.0-5.3, P < 0.001 |
Zou [4040 Zou Y-F, Feng X-L, Tao J-H, Su H, Pan F-M, Liao F-F, Fan Y, Ye D-Q. MetaAnalysis ofTNF-α promoter -308A/G polymorphism and SLE susceptibility in Asian populations. Rheumatol Int. 2011;31:1055-64. https://doi.org/10.1007/s00296-010-1392-7. https://doi.org/10.1007/s00296-010-1392-...
] |
TNF-α promoter-308 A/G |
A allele: OR = 1.44, 95% CI = 1.04-2.01, P = 0.030 |
Pan [4141 Pan H-F, Leng R-X, Wang C, Qin W-Z, Chen L-L, Zha Z-Q, Tao J-H, Ye D-Q. Association of TNF-α promoter-308 A/G polymorphism with susceptibility to systemic lupus erythematosus: a meta-analysis. Rheumatol Int. 2012;32:2083-92. https://doi.org/10.1007/s00296-011-1924-9. https://doi.org/10.1007/s00296-011-1924-...
] |
TNF-α promoter-308 A/G |
A/A versus G/G: OR = 3.69, 95% CI = 2.63-5.17, P < 0.001 |
Yang [4242 Yang Z-C, Xu F, Tang M, Xiong X. Association between TNF-α promoter -308 A/G polymorphism and systemic lupus erythematosus susceptibility: a case-control study and meta-analysis. Scand J Immunol. 2017;85:197-210. https://doi.org/10.1111/sji.12516. https://doi.org/10.1111/sji.12516...
] |
TNF-α promoter-308 A/G |
A allele: OR = 2.18, 95% CI = 1.72-2.78, P < 0.001 |
Chen [4343 Chen L, Huang Z, Liao Y, Yang B, Zhang J. Association between tumor necrosis factor polymorphisms and rheumatoid arthritis as well as systemic lupus erythematosus: a meta-analysis. Br J Med Biol Res. 2019;52:e7927. https://doi.org/10.1590/1414-431X20187927. https://doi.org/10.1590/1414-431X2018792...
] |
TNF-α promoter-308 A/G |
A versus G: OR = 1.78, 95% CI = 1.45-2.19, P < 0.001 |
Fan [4444 Fan Y, Tao J-H, Zhang L-P Li L-H, Ye D-Q. The Association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis. Int J Immunogenet. 2011;38:151-9. https://doi.org/10.1111/j.1744-313X.2010.00990.x. https://doi.org/10.1111/j.1744-313X.2010...
] |
TNFAIP3, rs2230926 |
OR = 1.83, 95% CI = 1.55-2.16, P < 0.001 |
Lee [4545 Lee YH, Song GG. Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis. Genet Test Mol Biomarkers. 2012;16:1105-10. https://doi.org/10.1089/gtmb.2012.0096. https://doi.org/10.1089/gtmb.2012.0096...
] |
TNFAIP3, rs2230926 |
OR = 1.85, 95% CI = 1.55-2.21, P < 0.001 |
Liu [4747 Liu X, Qin H, Wu J, Xu J. Association of TNFAIP3 and TNIP1 polymorphisms with systemic lupus erythematosus risk: a meta-analysis. Gene. 2018;668:155-65. https://doi.org/10.1016/j.gene.2018.05.062. https://doi.org/10.1016/j.gene.2018.05.0...
] |
TNFAIP3, rs2230926 |
G allele: OR = 1.64, 95% CI = 1.46-1.85, P < 0.010 |
Lu [4848 Lu M-M, Xu W-D, Yang J, Ye Q-L, Feng C-C, Li J, Pan H-F, Tao J-H, Wang J, Ye D-Q. Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis. Mod Rheumatol. 2013;23:686-93. https://doi.org/10.1007/s10165-012-0708-8. https://doi.org/10.1007/s10165-012-0708-...
] |
TNFSF4, rs2205960 |
OR = 1.33, 95% CI = 1.23-1.44, P < 0.001 |
Wang [4949 Wang J-M, Yuan Z-C, Huang A-F, Xu W-D. Association of TNFSF4 rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus susceptibility: a meta-analysis. Lupus. 2019;28:1197-204. https://doi.org/10.1177/0961203319862610. https://doi.org/10.1177/0961203319862610...
] |
TNFSF4, rs2205960 |
OR = 1.93, 95% CI = 1.50-2.49, P < 0.001 |
Moreno-Eutimio [5151 Moreno-Eutimio MA, Martinez-Aleman CE, Aranda-Uribe IS, Aquino-Jar- quin G, Cabello-Gutierrez C, Fragoso JM, Barbosa-Cobos RE, Saavedra MA, Ramirez-Bello J. TNFSF4 is a risk factor to systemic lupus erythematosus in a Latin American population. Clin Rheumatol. 2021;40:929-39. https://doi.org/10.1007/s10067-020-05332-9. https://doi.org/10.1007/s10067-020-05332...
] |
TNFSF4, rs2205960 |
G vs T: OR = 1.32, P = 0.004 |
Fu [5050 Fu Y, Lin Q, Zhang Z-R. Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis. Adv Rheumatol. 2021;61:59. https://doi.org/10.1186/s42358-021-00215-2. https://doi.org/10.1186/s42358-021-00215...
] |
TNFSF4, rs2205960 |
OR = 1.42, 95% CI = 1.36-1.49, P < 0.001 |
Xu [5252 Xu K, Peng H, Zhou M, Wang W, Li R, Zhu K-K, Zhang M, Wen P-F, Pan H-F, Ye D-Q. Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Gene. 2013;517:46-54. https://doi.org/10.1016/j.gene.2012.12.092. https://doi.org/10.1016/j.gene.2012.12.0...
] |
TRAF1/C5, rs10818488 |
OR = 1.25, 95% CI = 1.06-1.47, P = 0.008 |
Zhu [5353 Zhu L, Chen P, Sun X, Zhang S. Associations between polymorphisms in the IL-1 gene and the risk of rheumatoid arthritis and systemic lupus erythematosus: evidence from a meta-analysis. Int Arch Allergy Immunol. 2021;182:234-42. https://doi.org/10.1159/000510641. https://doi.org/10.1159/000510641...
] |
IL-1B -31 T/C |
OR = 1.64, 95% CI = 1.03-2.62, P = 0.040 |
Wang [5858 Wang B, Zhu J-M, Fan Y-G, Xu W-D, Cen H, Pan H-F, Ye D-Q. Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: a meta-analysis. Gene. 2013;519:209-16. https://doi.org/10.1016/j.gene.2013.01.026. https://doi.org/10.1016/j.gene.2013.01.0...
] |
IL-10-1082A/G, rs1800896 |
OR = 1.20, 95% CI = 1.03-1.41 |
Yin [2828 Yin Q, Wu L-C, Zheng L, Han M-Y, Hu L-Y, Zhao P-R Bai W-Y, Zhu X-W, Xia J-W, Wang X-B, et al. Comprehensive assessment of the Association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis. Arch Dermatol Res. 2018;310:711-28. https://doi.org/10.1007/s00403-018-1858-0. https://doi.org/10.1007/s00403-018-1858-...
] |
IL-10-1082A/G, rs1800896 |
GG versus AA: OR = 1.54, 95% CI = 1.14-2.07, P = 0.005 |
Niu [6262 Niu Z, Zhang P Tong YValue of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis. Int J Rheum Dis. 2015;18:17-28. https://doi.org/10.1111/1756-185X.12528. https://doi.org/10.1111/1756-185X.12528...
] |
HLA-DR3, DR9, DR15 |
HLA-DR3: OR = 1.88, 95% CI = 1.58-2.23, P < 0.001 |
Xue [6363 Xue K, Niu W-Q, Cui Y Association of HLA-DR3 and HLA-DR15 polymorphisms with risk of systemic lupus erythematosus. Chin Med J (Engl). 2018;131:2844-51. https://doi.org/10.4103/0366-6999.246058. https://doi.org/10.4103/0366-6999.246058...
] |
HLA-DR3, DR15 |
HLA-DR15: OR = 1.68, 95% CI = 1.33-2.11, P = 0.001 |
Hu [6565 Hu W, Ren H. A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus. Int J Immunogenet. 2011;38:411-7. https://doi.org/10.1111/j.1744-313X.2011.01025.x. https://doi.org/10.1111/j.1744-313X.2011...
] |
IRF5, rs2004640 |
OR = 1.41, 95% CI = 1.34-1.49, P < 0.001 |
Wang [6666 Wang J-M, Huang A-F, Yuan Z-C, Su L-C, Xu W-D. Association of IRF5 rs2004640 polymorphism and systemic lupus erythematosus: a metaanalysis. Int J Rheum Dis. 2019;22:1598-606. https://doi.org/10.1111/1756-185X.13654. https://doi.org/10.1111/1756-185X.13654...
] |
IRF5, rs2004640 |
OR = 1.39, 95% CI = 1.28-1.52, P < 0.001 |
Li [6767 Li Y, Chen S, Li P, Wu Z, Li J, Liu B, Zhang F, Li Y. Association of the IRF5 rs2070197 polymorphism with systemic lupus erythematosus: a metaanalysis. Clin Rheumatol. 2015;34:1495-501. https://doi.org/10.1007/s10067-015-3036-5. https://doi.org/10.1007/s10067-015-3036-...
] |
IRF5, rs2070197 |
OR = 2.13, 95% CI = 1.86-2.44, P < 0.001 |
Ji [6868 Ji JD, Lee WJ, Kong KA, Woo JH, Choi SJ, Lee YH, Song GG. Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep. 2010;37:141-7. https://doi.org/10.1007/s11033-009-9553-z. https://doi.org/10.1007/s11033-009-9553-...
] |
STAT4, rs7574865 |
OR = 1.57, 95% CI = 1.44-1.71 |
Yuan [6969 Yuan H, Feng J-B, Pan H-F, Qiu L-X, Li L-H, Zhang N, Ye D-Q. A metaanalysis of the association of STAT4 polymorphism with systemic lupus erythematosus. Mod Rheumatol. 2010;20:257-62. https://doi.org/10.1007/s10165-010-0275-9. https://doi.org/10.1007/s10165-010-0275-...
] |
STAT4, rs7574865 |
OR = 1.65, 95% CI = 1.56-1.75, P < 0.001 |
Wang [7070 Wang J-M, Xu W-D, Huang A-F. Association of STAT4 gene rs7574865, rs10168266 polymorphisms and systemic lupus erythematosus susceptibility: a meta-analysis. Immunol Invest. 2021;50:282-94. https://doi.org/10.1080/08820139.2020.1752712. https://doi.org/10.1080/08820139.2020.17...
] |
STAT4, rs7574865 |
OR = 1.56, 95% CI = 1.51-1.61, P < 0.001 |
Ji [7373 Ji JD, Cha ES, Lee WJ. Association of MiR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis. Lupus. 2014;23:1023-30. https://doi.org/10.1177/0961203314534512. https://doi.org/10.1177/0961203314534512...
] |
MiR-146a, rs2431697 |
OR = 1.24, 95% CI = 1.13-1.37 |
Liu [7575 Liu F, Liang Y, Zhao Y, Chen L, Wang X, Zhang C. Meta-analysis of association of microRNAs genetic variants with susceptibility to rheumatoid arthritis and systemic lupus erythematosus. Medicine. 2021;100:e25689. https://doi.org/10.1097/MD.0000000000025689. https://doi.org/10.1097/MD.0000000000025...
] |
MiR-146a, rs2431697 |
OR = 1.56, 95% CI = 1.20-1.92, P = 0.001 |
Fan [7777 Fan Y, Li L-H, Pan H-F, Tao J-H, Sun Z-Q, Ye D-Q. Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis. J Eur Acad Dermatol Venereol. 2011;25:271-5. https://doi.org/10.1111/j.1468-3083.2010.03776.x. https://doi.org/10.1111/j.1468-3083.2010...
] |
ITGAM, rs1143679 |
AA versus GG: OR = 3.54, 95% CI = 2.77-4.52 |
Ebrahimiyan [7676 Ebrahimiyan H, Mostafaei S, Aslani S, Faezi ST, Farhadi E, Jamshidi A, Mahmoudi M. Association between complement gene polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis. Clin Exp Med. 2021. https://doi.org/10.1007/s10238-021-00758-0. https://doi.org/10.1007/s10238-021-00758...
] |
ITGAM, rs1143679 |
OR = 1.97, 95% CI = 1.76-2.20, P < 0.001 |
Protective
|
|
|
Niu [6262 Niu Z, Zhang P Tong YValue of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis. Int J Rheum Dis. 2015;18:17-28. https://doi.org/10.1111/1756-185X.12528. https://doi.org/10.1111/1756-185X.12528...
] |
HLA-DR4, DR11, DR14 |
HLA-DR14: OR = 0.47, 95% CI = 0.59-0.95, P < 0.050 |
Hu [6565 Hu W, Ren H. A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus. Int J Immunogenet. 2011;38:411-7. https://doi.org/10.1111/j.1744-313X.2011.01025.x. https://doi.org/10.1111/j.1744-313X.2011...
] |
IRF5, rs729302, rs2280714 |
rs729302: OR = 0.78, 95% CI = 0.74-0.83, P < 0.001 |
Ebrahimiyan [7676 Ebrahimiyan H, Mostafaei S, Aslani S, Faezi ST, Farhadi E, Jamshidi A, Mahmoudi M. Association between complement gene polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis. Clin Exp Med. 2021. https://doi.org/10.1007/s10238-021-00758-0. https://doi.org/10.1007/s10238-021-00758...
] |
MBL, rs1800451 |
OR = 0.64, 95% CI = 0.42-0.99, P = 0.044 |
Contradictory
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|
|
Yu [3838 Yu L, Shao M, Zhou T, Xie H, Wang F, Kong J, Xu S, Shuai Z, Pan F. Association of CTLA-4 (+49 A/G) polymorphism with susceptibility to autoimmune diseases: a meta-analysis with trial sequential analysis. Int Immunopharmacol. 2021;96:107617. https://doi.org/10.1016/j.intimp.2021.107617. https://doi.org/10.1016/j.intimp.2021.10...
] |
CTLA-4, rs231775 |
No association |
Chang [3636 Chang W-W, Zhang L, Yao Y-S, Su H. Association between CTLA-4 exon-1 +49A/G polymorphism and systemic lupus erythematosus: an updated analysis. Mol Biol Rep. 2012;39:9159-65. https://doi.org/10.1007/s11033-012-1788-4. https://doi.org/10.1007/s11033-012-1788-...
] |
CTLA-4, rs231775 |
GG versus AA: OR = 1.53, 95% CI = 1.12-2.10 |
Zhai [3737 Zhai J-X, Zou L-W, Zhang Z-X, Fan W-J, Wang H-Y, Liu T, Ren Z, Dai R-X, Ye D. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Mol Biol Rep. 2013;40:5213-23. https://doi.org/10.1007/s11033-012-2125-7. https://doi.org/10.1007/s11033-012-2125-...
] |
CTLA-4, rs231775 |
GG + GA versus AA: OR = 0.85,95% CI = 0.73-0.99, P = 0.04C |
Lee [3535 Lee YH, Harley JB, Nath SK. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum Genet. 2005;116:361-7. https://doi.org/10.1007/s00439-004-1244-1. https://doi.org/10.1007/s00439-004-1244-...
] |
CTLA-4, rs231775 |
GG genotype: OR = 1.29, 95% CI = 1.03-1.56, P = 0.011 |
Lee [5454 Lee YH, Lee HS, Choi SJ, Ji JD, Song GG. The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lupus. 2012;21:60-7. https://doi.org/10.1177/0961203311422711. https://doi.org/10.1177/0961203311422711...
] |
IL-6-174 G/C, rs1800795 |
OR = 1.34, 95% CI = 1.05-1.72, P = 0.018 |
Yang [5555 Yang Z, Liang Y, Qin B, Zhong R. A meta-analysis of the association of IL-6 -174 G/C and -572 G/C polymorphisms with systemic lupus erythematosus risk. Rheumatol Int. 2014;34:199-205. https://doi.org/10.1007/s00296-013-2855-4. https://doi.org/10.1007/s00296-013-2855-...
] |
IL-6-174 G/C, rs1800795 |
OR = 1.64, 95% CI = 1.10-2.45, P = 0.016 |
Cui [5656 Cui YX, Fu CW, Jiang F, Ye LX, Meng W. Association of the interleukin-6 polymorphisms with systemic lupus erythematosus: a meta-analysis. Lupus. 2015;24:1308-17. https://doi.org/10.1177/0961203315588971. https://doi.org/10.1177/0961203315588971...
] |
IL-6-174 G/C, rs1800795 |
OR = 1.61, 95% CI = 1.16-2.24 |
Liu [5757 Liu J, Liao M-Q, Cao D-F, Yang Y, Yang Y, Liu Y-H, Zeng F-F, Chen X-H. The association between interleukin-6 gene polymorphisms and risk of systemic lupus erythematosus: a meta-analysis with trial sequential analysis. Immunol Invest. 2021;50:259-72. https://doi.org/10.1080/08820139.2020.1769646. https://doi.org/10.1080/08820139.2020.17...
] |
IL-6-174 G/C, rs1800795 |
OR = 0.71, 95% CI = 0.56-0.88, P = 0.020 |
Yang [5555 Yang Z, Liang Y, Qin B, Zhong R. A meta-analysis of the association of IL-6 -174 G/C and -572 G/C polymorphisms with systemic lupus erythematosus risk. Rheumatol Int. 2014;34:199-205. https://doi.org/10.1007/s00296-013-2855-4. https://doi.org/10.1007/s00296-013-2855-...
] |
IL-6-572 G/C, rs1800796 |
OR = 1.49,95% CI = 1.10-2.01, P = 0.009 |
Liu [5757 Liu J, Liao M-Q, Cao D-F, Yang Y, Yang Y, Liu Y-H, Zeng F-F, Chen X-H. The association between interleukin-6 gene polymorphisms and risk of systemic lupus erythematosus: a meta-analysis with trial sequential analysis. Immunol Invest. 2021;50:259-72. https://doi.org/10.1080/08820139.2020.1769646. https://doi.org/10.1080/08820139.2020.17...
] |
IL-6-572 G/C, rs1800796 |
No association |
Lee [5454 Lee YH, Lee HS, Choi SJ, Ji JD, Song GG. The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lupus. 2012;21:60-7. https://doi.org/10.1177/0961203311422711. https://doi.org/10.1177/0961203311422711...
] |
IL-6-572 G/C, rs1800796 |
No association |
Wen [6161 Wen D, Liu J, Du X, Dong J-Z, Ma C-S. Association of interleukin-18 (-137G/C) polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Int Rev Immunol. 2014;33:34-44. https://doi.org/10.3109/08830185.2013.816699. https://doi.org/10.3109/08830185.2013.81...
] |
IL-18-137G/C, rs187238 |
OR = 1.21, 95% CI = 0.91-1.60 |
Chen [6060 Chen S, Jiang F, Ren J, Liu J, Meng W. Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis. BMC Med Genet. 2012;13:107. https://doi.org/10.1186/1471-2350-13-107. https://doi.org/10.1186/1471-2350-13-107...
] |
IL-18-137G/C, rs187238 |
OR = 1.17, 95% CI = 0.95-1.44, P = 0.150 |
Ji [7373 Ji JD, Cha ES, Lee WJ. Association of MiR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis. Lupus. 2014;23:1023-30. https://doi.org/10.1177/0961203314534512. https://doi.org/10.1177/0961203314534512...
] |
MiR-146a, rs57095329 |
OR = 1.25, 95% CI = 1.17-1.35 |
Fu [7474 Fu L, Jin L, Yan L, Shi J, Wang H, Zhou B, Wu X. Comprehensive review of genetic association studies and meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility. Hum Immunol. 2016;77:1-6. https://doi.org/10.1016/j.humimm.201409.002. https://doi.org/10.1016/j.humimm.201409....
] |
MiR-146a, rs57095329 |
OR = 1.26, 95% CI = 1.14-1.41 |
Liu [7575 Liu F, Liang Y, Zhao Y, Chen L, Wang X, Zhang C. Meta-analysis of association of microRNAs genetic variants with susceptibility to rheumatoid arthritis and systemic lupus erythematosus. Medicine. 2021;100:e25689. https://doi.org/10.1097/MD.0000000000025689. https://doi.org/10.1097/MD.0000000000025...
] |
MiR-146a, rs57095329 |
OR = 1.17, 95% CI = 0.84-1.65, P = 0.360 |
Unrelated
|
|
|
Yin [2828 Yin Q, Wu L-C, Zheng L, Han M-Y, Hu L-Y, Zhao P-R Bai W-Y, Zhu X-W, Xia J-W, Wang X-B, et al. Comprehensive assessment of the Association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis. Arch Dermatol Res. 2018;310:711-28. https://doi.org/10.1007/s00403-018-1858-0. https://doi.org/10.1007/s00403-018-1858-...
] |
IL-10, rs1800871, rs1800872 |
NA |
Yuan [5959 Yuan Y, Wang X, Ren L, Kong Y, Bai J, Yan Y Associations between interleukin-10 gene polymorphisms and systemic lupus erythematosus risk: a meta-analysis with trial sequential analysis. Clin Exp Rheumatol. 2019;37:242-53.] |
IL-10, rs1800871, rs1800872 |
NA |
Niu [6262 Niu Z, Zhang P Tong YValue of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis. Int J Rheum Dis. 2015;18:17-28. https://doi.org/10.1111/1756-185X.12528. https://doi.org/10.1111/1756-185X.12528...
] |
HLA-DR8 |
NA |