Intra-articular corticosteroids |
|
Ward 2021 [ 2020 Ward MM. Osteoarthritis care and risk of total knee arthroplasty among medicare beneficiaries: a population-based study of regional covariation. Arthritis Rheumatol. 2021;73(12):1-28. https://doi.org/10.1002/art.41878. https://doi.org/10.1002/art.41878...
] |
Cohort study |
67 |
Knee |
139,529/387,702 |
35.99 |
|
Zeng 2019 [ 2323 Zeng C, Lane NE, Hunter DJ, Wei J, Choi HK, McAlindon TE, et al. Intraarticular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative. Osteoarthr Cartil. 2019;27(6):855-62. https://doi.org/10.1016/j.joca.2019.01.007. https://doi.org/10.1016/j.joca.2019.01.0...
] |
Cohort study |
48 |
Knee |
33/148 |
22.30 |
|
Delbarre 2017 [ 3636 Delbarre A, Amor B, Bardoulat I, Tetafort A, Pelletier-Fleury N. Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis—a Cox model analysis. PLoS ONE. 2017;12(11):e0187227. https://doi.org/10.1371/journal.pone.0187227. https://doi.org/10.1371/journal.pone.018...
] |
Cohort study |
44 |
Knee |
366/5306 |
6.90 |
|
Walter 2019 [ 2424 Walter WR, Bearison C, Slover JD, Gold HT, Gyftopoulos S. Clinical and patient-reported outcomes after image-guided intra-articular therapeutic hip injections for osteoarthritis-related hip pain: a retrospective study. Skeletal Radiol. 2019;48(5):713-9. https://doi.org/10.1007/s00256-018-3113-3. https://doi.org/10.1007/s00256-018-3113-...
] |
Cohort study |
NA |
Hip |
49/113 |
43.36 |
|
Villoutreix 2006 [ 5454 Villoutreix C, Pham T, Tubach F, Dougados M, Ayral X. Intraarticular glucocorticoid injections in rapidly destructive hip osteoarthritis. Jt Bone Spine. 2006;73(1):66-71. https://doi.org/10.1016/j.jbspin.2005.06.002. https://doi.org/10.1016/j.jbspin.2005.06...
] |
Cohort study |
> 6 |
Hip |
27/28 |
96.43 |
|
Pope 2008 [ 5151 Pope JE, Mccrea K, Stevens A, Ouimet JM. The relationship between NSAID use and osteoarthritis (OA) severity in patients with hip and knee OA: results of a case control study of NSAID use comparing those requiring hip and knee replacements to those in whom surgery was not recommended. Med Sci Monit. 2008;14(12):Cr604-10. https://doi.org/10.1016/j.mehy.2008.07.011. https://doi.org/10.1016/j.mehy.2008.07.0...
] |
Case-control study |
24 |
Hip |
26/36 |
72.22 |
|
Pope 2008 [ 5151 Pope JE, Mccrea K, Stevens A, Ouimet JM. The relationship between NSAID use and osteoarthritis (OA) severity in patients with hip and knee OA: results of a case control study of NSAID use comparing those requiring hip and knee replacements to those in whom surgery was not recommended. Med Sci Monit. 2008;14(12):Cr604-10. https://doi.org/10.1016/j.mehy.2008.07.011. https://doi.org/10.1016/j.mehy.2008.07.0...
] |
Case-control study |
24 |
Knee |
46/124 |
37.10 |
Hyaluronic acid |
|
Ward 2021 [ 2020 Ward MM. Osteoarthritis care and risk of total knee arthroplasty among medicare beneficiaries: a population-based study of regional covariation. Arthritis Rheumatol. 2021;73(12):1-28. https://doi.org/10.1002/art.41878. https://doi.org/10.1002/art.41878...
] |
Cohort study |
67 |
Knee |
73,436/187,268 |
39.21 |
|
Concoff 2021 [ 2121 Ong KL, Runa M, Lau E, Altman RD. Cost-of-illness of knee osteoarthritis: potential cost savings by not undergoing arthroplasty within the first 2 years. Clinicoecon Outcomes Res. 2019;11:245-55. https://doi.org/10.2147/CEOR.S170119. https://doi.org/10.2147/CEOR.S170119...
] |
Cohort study |
24 |
Knee |
52,212/181,631 |
28.75 |
|
Ong 2019 [ 2222 Concoff A, Niazi F, Farrokhyar F, Alyass A, Rosen J, Nicholls M. Delay to TKA and costs associated with knee osteoarthritis care using intra-articular hyaluronic acid: analysis of an administrative database. Clin Med Insights Arthritis Musculoskelet Disord. 2021;14:1-8. https://doi.org/10.1177/1179544121994092. https://doi.org/10.1177/1179544121994092...
] |
Cohort study |
24 |
Knee |
8315/56,093 |
14.82 |
|
Dasa2018 [ 3030 Dasa V, Lim S, Heeckt P. Real-world evidence for safety and effectiveness of repeated courses of hyaluronic acid injections on the time to knee replacement surgery. Am J Orthop (Belle Mead NJ). 2018;47(7):058. https://doi.org/10.12788/ajo.2018.0058. https://doi.org/10.12788/ajo.2018.0058...
] |
Cohort study |
36 |
Knee |
44/887 |
4.96 |
|
Bowman 2018 [ 3131 Bowman EN, Hallock JD, Throckmorton TW, Azar FM. Hyaluronic acid injections for osteoarthritis of the knee: predictors of successful treatment. Int Orthop. 2018;42(4):733-40. https://doi.org/10.1007/s00264-017-3731-8. https://doi.org/10.1007/s00264-017-3731-...
] |
Cohort study |
27 |
Knee |
20/102 |
19.61 |
|
Annaniemi 2018 [ 3232 Annaniemi JA, Pere J, Giordano S. Platelet-rich plasma versus hyaluronic acid injections for knee osteoarthritis: a propensity-score analysis. Scand J Surg. 2019;108(4):329-37. https://doi.org/10.1177/1457496918812218. https://doi.org/10.1177/1457496918812218...
] |
Cohort study |
17 |
Knee |
31/86 |
36.05 |
|
Delbarre 2016 [ 3939 Demehri S, Nejad NH, Roemer F, Guermazi A, Demehri S. Chondroitin sulfate and glucosamine supplementation is associated with higher incidence of radiographic knee osteoarthritis and subsequent knee replacement: 9 years of follow-up data from the osteoarthritis initiative. Osteoarthr Cartil. 2016;24:S307. https://doi.org/10.1016/j.joca.2016.01.554. https://doi.org/10.1016/j.joca.2016.01.5...
] |
Cohort study |
42 |
Knee |
1296/9476 |
13.68 |
|
Turajane 2009 [ 4848 Turajane T, Amphansap T, Labpiboonpong V, Maungsiri S. Total knee replacement following repeated cycles of intra-articular sodium hyaluro-nate (500-730 Kda) in failed conservative treatment of knee osteoarthritis: a 54-month follow-up. J Med Assoc Thai. 2009;92(6):S63-8. ] |
Cohort study |
54 |
Knee |
52/183 |
28.42 |
|
Migliore 2012 [ 4444 Migliore A, Bella A, Bisignani M, Calderaro M, De Amicis D, Logroscino G, et al. Total hip replacement rate in a cohort of patients affected by symptomatic hip osteoarthritis following intra-articular sodium hyaluronate (MW 1500-2000 kDa) ORTOBRIX study. Clin Rheumatol. 2012;31(8):1187-96. https://doi.org/10.1007/s10067-012-1994-4. https://doi.org/10.1007/s10067-012-1994-...
] |
Cohort study |
48 |
Hip |
32/176 |
18.18 |
|
van den Bekerom 2008 [ 4949 van den Bekerom MP, Rys B, Mulier M. Viscosupplementation in the hip: evaluation of hyaluronic acid formulations. Arch Orthop Trauma Surg. 2008;128(3):275-80. https://doi.org/10.1007/s00402-007-0374-z. https://doi.org/10.1007/s00402-007-0374-...
] |
Cohort study |
36 |
Hip |
59/120 |
49.17 |
|
Gaston 2007 [ 5353 Gaston MS, Tiemessen CH, Philips JE. Intra-articular hip viscosupplementation with synthetic hyaluronic acid for osteoarthritis: efficacy, safety and relation to pre-injection radiographs. Arch Orthop Trauma Surg. 2007;127(10):899-903. https://doi.org/10.1007/s00402-007-0363-2. https://doi.org/10.1007/s00402-007-0363-...
] |
Cohort study |
6 |
Hip |
4/15 |
26.67 |
|
Turajane 2017 [ 4848 Turajane T, Amphansap T, Labpiboonpong V, Maungsiri S. Total knee replacement following repeated cycles of intra-articular sodium hyaluro-nate (500-730 Kda) in failed conservative treatment of knee osteoarthritis: a 54-month follow-up. J Med Assoc Thai. 2009;92(6):S63-8. ] |
RCT |
12 |
Knee |
3/20 |
15.00 |
|
Ong 2019b [ 2222 Concoff A, Niazi F, Farrokhyar F, Alyass A, Rosen J, Nicholls M. Delay to TKA and costs associated with knee osteoarthritis care using intra-articular hyaluronic acid: analysis of an administrative database. Clin Med Insights Arthritis Musculoskelet Disord. 2021;14:1-8. https://doi.org/10.1177/1179544121994092. https://doi.org/10.1177/1179544121994092...
] |
Cohort study |
24 |
Knee |
8315/56,093 |
14.82 |
|
Boutefnouchet 2017 [ 3737 Boutefnouchet T, Puranik G, Holmes E, Bell KM. Hylan GF-20 viscosupplementation in the treatment of symptomatic osteoarthritis of the knee: clinical effect survivorship at 5 years. Knee Surg Relat Res. 2017;29(2):129-36. https://doi.org/10.5792/ksrr.16.061. https://doi.org/10.5792/ksrr.16.061...
] |
Cohort study |
60 |
Knee |
26/82 |
31.70 |
|
Migliore 2012 [ 4343 Migliore A, et al. The impact of treatment with hylan G-F 20 on progression to total hip arthroplasty in patients with symptomatic hip OA: a retrospective study. Curr Med Res Opin. 2012;28(5):755-60. https://doi.org/10.1007/s10067-013-2338-8. https://doi.org/10.1007/s10067-013-2338-...
] |
Cohort study |
60 |
Hip |
84/224 |
37.50 |
Bisphosphonates |
|
Neogi 2018 [ 2727 Neogi T, Li S, Peloquin C, Misra D, Zhang Y. Effect of bisphosphonates on knee replacement surgery. Ann Rheum Dis. 2018;77(1):92-7. https://doi.org/10.1136/annrheumdis-2017-211811. https://doi.org/10.1136/annrheumdis-2017...
] |
Cohort study |
3 |
Knee |
138/2006 |
6.88 |
|
Fu 2017 [ 3535 Fu SH, Wang CY, Yang RS, Wu FL, Hsiao FY. Bisphosphonate use and the risk of undergoing total knee arthroplasty in osteoporotic patients with osteoarthritis. J Bone Jt Surg. 2017;99(11):938-46. https://doi.org/10.2106/JBJS.16.00385. https://doi.org/10.2106/JBJS.16.00385...
] |
Cohort study |
14 |
Knee |
595/16,276 |
3.66 |
|
Turajane 2017 [ 3333 Turajane T, Chaveewanakorn U, Fongsarun W, Aojanepong J, Papadopoulos KI. Avoidance of total knee arthroplasty in early osteoarthritis of the knee with intra-articular implantation of autologous activated peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial with differential effects of growth factor addition. Stem Cells Int. 2017;2017:1-10. https://doi.org/10.1155/2017/8925132. https://doi.org/10.1155/2017/8925132...
] |
RCT |
12 |
Knee |
3/20 |
15.00 |
|
Nishii 2013 [ 4242 Nishii T, Tamura S, Shiomi T, Yoshikawa H, Sugano N. Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial. Clin Rheumatol. 2013;32(12):1759-66. ] |
RCT |
24 |
Hip |
7/30 |
23.33 |
|
SYSADOA |
|
|
|
|
|
|
Bruyere 2008 [ 5252 Pavelka K, Giacovelli G, Bruyere O, Olejarova M, Reginster JY, Deroisy R, et al. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials. Osteoarthr Cartil. 2008;16(2):254-60. https://doi.org/10.1016/j.joca.2007.06.011. https://doi.org/10.1016/j.joca.2007.06.0...
] |
Cohort study |
62 |
Knee |
9/144 |
6.25 |
|
Dorais 2018 [ 2929 Dorais M, Martel-Pelletier J, Raynauld JP, Delorme P, Pelletier JP. Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort. Arthritis Res Ther. 2018;20(1):172. https://doi.org/10.1186/s13075-018-1656-2. https://doi.org/10.1186/s13075-018-1656-...
] |
Case-control study |
52 |
Knee |
88/283 |
31.10 |
|
Wildi 2011 [ 4646 Wildi LM, Raynauld JP, Martel-Pelletier J, Beaulieu A, Bessette L, Morin F, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011;70(6):982-9. https://doi.org/10.1136/ard.2010.140848. https://doi.org/10.1136/ard.2010.140848...
] |
RCT |
6 |
Knee |
0/35 |
0.00 |
|
Rozendaal 2008 [ 5050 Rozendaal RM, Koes BW, van Osch GJ, Uitterlinden EJ, Garling EH, Willemsen SP, et al. Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial. Ann Intern Med. 2008;148(4):268-77. https://doi.org/10.7326/0003-4819-148-4-200802190-00005. https://doi.org/10.7326/0003-4819-148-4-...
] |
RCT |
24 |
Hip |
13/111 |
11.71 |
NSAIDs |
|
Hafezi-Nejad 2016 [ 3838 Hafezi-Nejad N, Guermazi A, Roemer FW, Eng J, Zikria B, Demehri S. Long term use of analgesics and risk of osteoarthritis progressions and knee replacement: propensity score matched cohort analysis of data from the Osteoarthritis Initiative. Osteoarthr Cartil. 2016;24(4):597-604. https://doi.org/10.1016/j.joca.2015.11.003. https://doi.org/10.1016/j.joca.2015.11.0...
] |
Cohort study |
96 |
Knee |
29/173 |
16.76 |
|
Reijman 2005 [ 5555 Reijman M, Bierma-Zeinstra SM, Pols HA, Koes BW, Stricker BH, Hazes JM. Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study. Arthritis Rheum. 2005;52(10):3137-42. https://doi.org/10.1002/art.21357. https://doi.org/10.1002/art.21357...
] |
Cohort study |
79 |
Knee |
13/874 |
1.49 |
|
Reijman 2005 [ 5555 Reijman M, Bierma-Zeinstra SM, Pols HA, Koes BW, Stricker BH, Hazes JM. Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study. Arthritis Rheum. 2005;52(10):3137-42. https://doi.org/10.1002/art.21357. https://doi.org/10.1002/art.21357...
] |
Cohort study |
79 |
Hip |
116/2514 |
4.61 |
|
Gossec 2005 [ 5656 Gossec L, Tubach F, Baron G, Ravaud P, Logeart I, Dougados M. Predictive factors of total hip replacement due to primary osteoarthritis: a prospective 2 year study of 505 patients. Ann Rheum Dis. 2005;64(7):1028-32. https://doi.org/10.1136/ard.2004.029546. https://doi.org/10.1136/ard.2004.029546...
] |
Cohort study |
24 |
Hip |
139/331 |
41.99 |
|
Dorais 2018 [ 2929 Dorais M, Martel-Pelletier J, Raynauld JP, Delorme P, Pelletier JP. Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort. Arthritis Res Ther. 2018;20(1):172. https://doi.org/10.1186/s13075-018-1656-2. https://doi.org/10.1186/s13075-018-1656-...
] |
Case-control study |
52 |
Knee |
101/276 |
36.59 |
|
Klop 2012 [ 4545 Klop C, de Vries F, Lalmohamed A, Mastbergen SC, Leufkens HG, Noortvan der Laan WH, et al. COX-2-selective NSAIDs and risk of hip or knee replacements: a population-based case-control study. Calcif Tissue Int. 2012;91(6):387-94. https://doi.org/10.1007/s00223-012-9646-x. https://doi.org/10.1007/s00223-012-9646-...
] |
Case-control study |
91 |
Knee |
706/996 |
70.88 |
|
Raynauld 2011 [ 4747 Raynauld JP, Martel-Pelletier J, Haraoui B, Choquette D, Dorais M, Wildi LM, et al. Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation. Ann Rheum Dis. 2011;70(8):1382-8. https://doi.org/10.1136/ard.2010.146407. https://doi.org/10.1136/ard.2010.146407...
] |
Case-control study |
56 |
Knee |
18/123 |
14.63 |
|
Arends 2017 [ 4141 Arends RHGP, Karsdal MA, Verburg KM, West CR, Bay-Jensen AC, Keller DS. Identification of serological biomarker profiles associated with total joint replacement in osteoarthritis patients. Osteoarthr Cartil. 2017;25(6):866-77. https://doi.org/10.1016/j.joca.2017.01.006. https://doi.org/10.1016/j.joca.2017.01.0...
] |
Case-control study |
< 6 |
Knee/hip |
105/266 |
39.47 |
|
Klop 2012 [ 4545 Klop C, de Vries F, Lalmohamed A, Mastbergen SC, Leufkens HG, Noortvan der Laan WH, et al. COX-2-selective NSAIDs and risk of hip or knee replacements: a population-based case-control study. Calcif Tissue Int. 2012;91(6):387-94. https://doi.org/10.1007/s00223-012-9646-x. https://doi.org/10.1007/s00223-012-9646-...
] |
Case-control study |
91 |
Hip |
1099/1586 |
69.29 |
|
Pope 2008 [ 5151 Pope JE, Mccrea K, Stevens A, Ouimet JM. The relationship between NSAID use and osteoarthritis (OA) severity in patients with hip and knee OA: results of a case control study of NSAID use comparing those requiring hip and knee replacements to those in whom surgery was not recommended. Med Sci Monit. 2008;14(12):Cr604-10. https://doi.org/10.1016/j.mehy.2008.07.011. https://doi.org/10.1016/j.mehy.2008.07.0...
] |
Case-control study |
24 |
Knee/hip |
366/542 |
67.53 |
|
Balanescu 2012 [ 5959 Balanescu AR, Feist E, Wolfram G, Davignon I, Smith MD, Brown MT, et al. Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial. Ann Rheum Dis. 2014;73(9):1665-72. https://doi.org/10.1136/annrheumdis-2012-203164. https://doi.org/10.1136/annrheumdis-2012...
] |
RCT |
8 |
Knee/hip |
1/152 |
0.66 |
|
Schnitzer 2015 [ 4040 Schnitzer TJ, Ekman EF, Spierings EL, Greenberg HS, Smith MD, Brown MT. Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain. Ann Rheum Dis. 2015;74(6):1202-11. https://doi.org/10.1136/annrheumdis-2013-204905. https://doi.org/10.1136/annrheumdis-2013...
] |
RCT |
16 |
Knee/hip |
25/539 |
4.64 |
|
Ekman 2014 [ 5858 Ekman EF, Gimbel JS, Bello AE, Smith MD, Keller DS, Annis KM, et al. Efficacy and safety of intravenous tanezumab for the symptomatic treatment of osteoarthritis: 2 randomized controlled trials versus naproxen. J Rheumatol. 2014;41(11):2249-59. https://doi.org/10.3899/jrheum.131294. https://doi.org/10.3899/jrheum.131294...
] |
RCT |
6 |
Knee/hip |
1/211 |
0.47 |
|
ALHO 1988 [ 5757 Alho A, Jaer O, Slungaard U, Holme I. Piroxicam and naproxen in patients with osteoarthritis of the hip waiting for total hip replacement. Clin Rheumatol. 1988;7(2):208-13. https://doi.org/10.1007/BF02204456. https://doi.org/10.1007/BF02204456...
] |
RCT |
3-6 |
Hip |
38/252 |
15.08 |