Association of lipoprotein lipase (LPL) gene variants with hyperlipidemic acute pancreatitis in southeastern Chinese population

Li, Yingyi; Cai, Hehui; Lin, Yancheng; Huang, Zhipeng; Zhou, Apei; Huang, Tianhao; Zeng, Yue-e; Ye, Meizhen; Guo, Guiyuan; Huang, Zicheng

doi:10.20945/2359-4292-2023-0195

Yingyi Li Correspondence to: Yingyi Li liyingyi0924@126.com

designed and performed the study

recruited the subjects

drew blood samples

collected the data

performed the experiments

accomplished data analysis

wrote the paper

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0000-0002-9259-0487

Hehui Cai

performed the experiments

read and approved the manuscript

Clinical Laboratory, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0009-0001-2191-902X

Yancheng Lin

performed the experiments

accomplished data analysis

read and approved the manuscript

HI. Q Biomedical Laboratory, Third Floor Building 5 Derun Industrial Park, Taiwan Investment Zone, Quanzhou, People's Republic of China

https://orcid.org/0009-0006-4723-3110

Zhipeng Huang

recruited the subjects

drew blood samples

collected the data

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0000-0002-8414-6570

Apei Zhou

recruited the subjects

drew blood samples

collected the data

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0000-0002-0068-601X

Tianhao Huang

recruited the subjects

drew blood samples

collected the data

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0009-0008-8232-3714

Yue-e Zeng

recruited the subjects

drew blood samples

collected the data

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0000-0003-4807-9144

Meizhen Ye

recruited the subjects

drew blood samples

collected the data

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0009-0005-8153-8287

Guiyuan Guo

recruited the subjects

drew blood samples

collected the data

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0009-0009-1347-7952

Zicheng Huang

reviewed and edited the manuscript

read and approved the manuscript

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China

https://orcid.org/0009-0004-0299-6670

Correspondence to: Yingyi Li liyingyi0924@126.com

Disclosure: no potential conflict of interest relevant to this article was reported.

	Patients with HLAP (n = 54)	BAP controls (n = 26)	t (χ²)	p-value
Male, n (%)	39 (72.2%)	11 (42.3%)	6.701	0.010
Age (years)	38.80 ± 10.19	58.04 ± 14.04	–6.972	<0.001
SBP (mm Hg)	133.98 ± 16.25	140.12 ± 27.07	–1.067	0.294
DBP (mm Hg)	85.39 ± 11.51	82.96 ± 16.82	0.665	0.510
TG (mmol/L)	28.38 ± 18.99	1.30 ± 0.66	10.465	<0.001
TC (mmol/L)	11.57 ± 4.26	4.61 ± 0.91	11.493	<0.001
HDL-C (mmol/L)	0.89 ± 0.76	1.08 ± 0.32	–1.201	0.233
LDL-C (mmol/L)	2.29 ± 1.93	2.96 ± 0.63	–2.256	0.027
Non-HDL-C (mmol/L)	10.71 ± 4.03	3.53 ± 0.79	12.390	<0.001
FPG (mmol/L)	11.39 ± 6.08	11.88 ± 5.02	1.641	0.105
HBA (%)	8.59 ± 2.79	6.24 ± 1.18	5.190	<0.001
Drinking, n (%)	22 (40.7%)	2 (7.7%)	9.128	0.003
Smoking, n (%)	23 (42.6%)	0(0.0%)	15.543	<0.001
Hypertension, n (%)	10 (18.5%)	10 (38.5%)	3.723	0.054
Fatty liver, n (%)	47 (87.0%)	11 (42.3%)	17.611	<0.001
Diabetes, n (%)	33 (61.1%)	6 (23.1%)	10.161	0.001
Cholelithiasis, n (%)	5 (9.3%)	25 (96.2%)	56.539	<0.001
Hypertriglyceridemia, n (%)	54 (100.0%)	6 (23.1%)	55.385	<0.001
MSAP and SAP, n (%)	37 (68.6%)	18 (68.8%)	0.678	0.713
Recurrent AP, n (%)	30 (55.6%)	8 (30.8%)	4.324	0.038

SNP	Minor allele	N, MAF		χ ²	p-value	Clinical significance reported in ClinVar
SNP	Minor allele	Patients with HLAP (n = 54)	BAP controls (n = 26)	χ ²	p-value	Clinical significance reported in ClinVar
rs3735959	C	2 (0.020)	2 (0.042)	0.546	0.460	Benign/Likely benign
rs371282890	G	5 (0.046)	0 (0)	2.485	0.175	Pathogenic
rs761886494	A	1 (0.009)	0 (0)	0.498	1.000	Likely pathogenic
rs761265900	G	1 (0.009)	0 (0)	0.498	1.000	Not reported

Factor		Age of first onset (years)	β	p-value	HR	95%CI
Gender
	Male	39.24	0.937	0.002	2.551	1.398-4.655
	Female	50.87	–	–	1.000	-
rs371282890 genotype
	GC	32.20	1.126	0.018	3.083	1.208-7.869
	CC	44.36	–	–	1.000	–

rs371282890	Genotype
rs371282890	GC (n = 5)	CC in HLAP group (n = 49)	CC in all subjects (n = 75)
Age (year)	34.60 ± 10.71	39.22 ± 10.15	45.75 ± 14.65
TC (mmol/L)	15.99 ± 5.15	11.12 ± 3.95⁺ + p < 0.05 for statically significant difference between the GC group and the CC in the HLAP group.	8.86 ± 4.49^* * p < 0.05 for statically significant difference between the GC group and the CC in all subjects.
TG (mmol/L)	53.82 ± 22.07	17.29 ± 17.93⁺ + p < 0.05 for statically significant difference between the GC group and the CC in the HLAP group.	17.29 ± 17.93^* * p < 0.05 for statically significant difference between the GC group and the CC in all subjects.
HDL-C (mmol/L)	1.95 ± 1.75	0.78 ± 0.50	0.89 ± 0.46
LDL-C (mmol/L)	2.05 ± 2.99	2.32 ± 1.83	2.55 ± 1.54
Non-HDL-C (mmol/L)	14.04 ± 3.87	10.36 ± 3.92⁺ + p < 0.05 for statically significant difference between the GC group and the CC in the HLAP group.	7.92 ± 4.57^* * p < 0.05 for statically significant difference between the GC group and the CC in all subjects.
FPG (mmol/L)	11.88 ± 5.02	12.20 ± 6.42	11.39 ± 6.08
HBA (%)	9.14 ± 2.91	8.53 ± 2.80	7.76 ± 2.61

[1] Correspondence to: Yingyi Li liyingyi0924@126.com

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Association of lipoprotein lipase (LPL) gene variants with hyperlipidemic acute pancreatitis in southeastern Chinese population

ABSTRACT

Objective:

Results:

Conclusion: