Li, 2019 (4141. Li B, Wang M, Zhou L, Wen Q, Zou J. Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis. Braz J Otorhinolaryngol [Internet]. 2019. Available from: https://pubmed.ncbi.nlm.nih.gov/31653607/. https://pubmed.ncbi.nlm.nih.gov/31653607...
) |
Observational |
8 |
337 CRSP 179 CS |
Not given |
VDD association with CRSP, especially in patients with nasal polyps' patients. |
Zhou, 2019 (4242. Zhou YF, Luo BA, Qin LL. The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies. Medicine (Baltimore). 2019;98(38):e17252.) |
Observational |
8 |
20,966 |
Not given |
VDD patients experienced a significantly increased risk of CAP (OR = 1.64). |
Pham, 2019 (4343. Pham H, Rahman A, Majidi A, Waterhouse M, Neale RE. Acute respiratory tract infection and 25-hydroxyvitamin D concentration: A systematic review and meta-analysis. Int J Environ Res Public Health. 2019;16(17):3020.) |
Observational |
24 |
Risk of ARTI: 78,127; Severity of ARTI: 1,495 |
≥12 to 97 years |
Higher risk of ARTI in the lowest 25(OH)D category. For each 4 ng/mL ↓ in 25(OH)D, the Odds of ARTI ↑ by 1.02. This was a non-linear trend, with ↑ in risk of ARTI occurring at 25(OH)D < 15 ng/mL) |
Cariolou, 2019 (4444. Cariolou M, Cupp MA, Evangelou E, Tzoulaki I, Berlanga-Taylor AJ. Importance of Vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: A systematic review and meta-analysis. BMJ Open BMJ Open. 2019;9(5):e027666.) |
Observational |
52 |
7,434 |
0 to 18 years |
The prevalence of VDD (<20 ng/mL) was 54.6%. Children with sepsis prevalence was 64.0% in those with RTI. ↑ risk of death in VDD children. |
Gou, 2018 (4545. Gou X, Pan L, Tang F, Gao H, Xiao D. The association between Vitamin D status and tuberculosis in children: A meta-analysis. Medicine (Baltimore). 2018;97(35):e12179.) |
Observational |
10 |
2,672 |
<18 years |
TB was significantly associated with VDD in children. VD levels were significantly lower in TB patients than in controls |
Huang, 2017 (4646. Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, et al. Vitamin D deficiency and the risk of tuberculosis: A meta-analysis. Drug Des Devel Ther. 2017;11:91-102.) |
Observational |
38 |
3,599 TB 3,063 CS |
Not given |
Association between VDs and TB; VDD such as risk factor for TB. |
Jat, 2017 (4747. Jat KR. Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies. Trop Doct. 2017;47(1):77-84.) |
Observational |
12 |
2,279 |
0 to 5 years |
Children with LRTI were found to have significantly lower mean VD as compared to controls. There was likewise a correlation between VD levels and incidence and severity of LRTI. |
Feng, 2017 (4848. Feng H, Xun P, Pike K, Wills AK, Chawes BL, Bisgaard H, et al. In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies. J Allergy Clin Immunol. 2017;139(5):1508-17.) |
Observational |
16 |
Asthma: 8, 871; Wheeze: 9,072; RTI: 8, 359 |
0 to 9 years |
~28% of participants had 25(OH)D of ≥30 ng/mL. Birth cohort studies appointed that ↑ in utero exposure to 25(OH) D is inversely associated with the risk of asthma and wheeze during childhood, demonstrating more than 20% ↓ risk. |
Martineau, 2019 (2929. Martineau AR, Jolliffe DA, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, et al. Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis. Health Technol Assess. 2019;23(2):1-44.) |
RCTs |
25 |
11,321 |
0 to 95 years |
VDS ↓ the risk of ARI among all participants. Effects of VDS were stronger in individuals with a baseline 25(OH)D < 10 ng/mL than in those with a baseline 25(OH)D of ≥ 10 ng/mL. Daily or weekly VDS, but not in those receiving one or more bolus doses experienced benefits. |
Zhang, 2019 (4949. Zhang J, Chen C, Yang J. Effectiveness of vitamin D supplementation on the outcome of pulmonary tuberculosis treatment in adults: A meta-analysis of randomized controlled trials. Chin Med J (Engl). 2019;132(24):2950-9.) |
RCTs |
5 |
1,126 |
≥18 years |
VDS did not shorten the time to sputum culture and smear conversion and did not lead to an increase in the proportion of participants with negative sputum culture. However, it reduced the time to sputum culture conversion in the sub-group of participants with Taq/ tt genotype (HR 8.09) and improved the multidrug-resistant TB sputum culture conversion rate (RR 2.40). |
Wu, 2018 (5050. Wu HX, Xiong XF, Zhu M, Wei J, Zhuo KQ, Cheng DY. Effects of vitamin D supplementation on the outcomes of patients with pulmonary tuberculosis: A systematic review and meta-analysis. BMC Pulm Med. 2018;18(1):108.) |
RCTs |
8 |
1,787 |
26.7 to 43.7 years |
VDS ↑ the proportion of sputum smear and culture conversions, PCc, LC, and chest radiograph, but had no impact on adverse events and mortality. VDS can be considered as a combination therapy in PTB. |
Yakoob, 2016 (5151. Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016;11(11):CD008824.) |
RCTs |
4 |
3,198 |
<5 years |
VDD did not demonstrate benefit on the incidence of pneumonia, diarrhea, death or RI in children. |
Vuichard Gysin, 2016 (5252. Vuichard Gysin D, Dao D, Gysin CM, Lytvyn L, Loeb M. Effect of vitamin D3 supplementation on respiratory tract infections in healthy individuals: A systematic review and meta-Analysis of randomized controlled trials. PLoS One. 2016;11(9):e0162996.) |
RCTs |
15 |
7,053 |
Median age: 19 years |
73% of the participants that measured 25(OH)D were insufficient (≤20 ng/mL). In healthy individuals VDD does not reduce the risk of RTIs. |