Once weekly T4 oral replacement |
Non compliance |
Slightly larger dose than 7 times the daily dose |
– |
Rangan et al.1717. Rangan S, Tahran AA, Macleod AF, Moulik PK. Once weekly thyroxine treatment as a strategy to treat non-compliance. Postgrad Med J. 2007;83:e3.
|
Study including 100 people |
Once weekly T4 oral replacement |
Randomized crossover study |
Slightly larger dose than 7 times the daily dose |
– |
Rajput et al.1919. Rajput R, Pathak V. The Effect of Daily versus Weekly Levothyroxine Replacement on Thyroid Function Test in Hypothyroid Patients at a Tertiary Care Centre in Haryana. Eur Thyroid J. 2017;6(5):250-4. 8
|
Study including 100 people |
Once weekly T4 oral replacement |
Randomized crossover study |
Slightly larger dose than 7 times the daily dose |
– |
Grebe et al.1515. Grebe SKG, Cooke RR, Ford HC, Fagerström, JN, Cordwell DP, Lever NA, et al. Treatment of hypothyroidism with once weekly thyroxine. J Clin Endocrinol Metab. 1997;82:870-5.
|
Study including 12 people |
Once weekly T4 oral replacement |
Randomized crossover study |
Slightly larger dose than 7 times the daily dose |
– |
Bornschein et al.1616. Bornschein A, Paz-Filho G, Graf H, Carvalho GA. Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study. Arq Bras Endocrinol Metabol. 2012;56(4):250-8.
|
Study including 14 people |
Rectal administration (mostly suppositories) |
Crisis areas, problems in health supply |
Twice the oral dose |
– |
Kashiwagura et al.2121. Kashiwagura Y, Uchida S, Tanaka S, Watanabe H, Masuzawa M, Sasaki T, et al. Clinical efficacy and pharmacokinetics of levothyroxine suppository in patients with hypothyroidism. Biol Pharm Bull. 2014;37(4):666-70.
|
Study including 6 people |
Rectal in the form of enema |
Gastric outlet obstruction |
2000 μg as enema |
– |
Khaled et al.2020. Khaled A, Obeidat NA, Saadeh A, Sohail B. Successful Management of Hypothyroidism in Gastric Outlet Obstruction Using Levothyroxine Rectal Enemas: A Case Report. Am J Case Rep. 2018;19:903-5.
|
Case report |
Intramuscular |
Non-compliance, gastrointestinal diseases |
Twice weekly application of T4 |
– |
Taylor2525. Taylor PN, Tabasum A, Sanki G, Burberry D, Tennant BP, White J, et al. Weekly Intramuscular Injection of Levothyroxine following Myxoedema: A Practical Solution to an Old Crisis. Case Rep Endocrinol. 2015;2015:169-194.
|
Case report |
Subcutaneous |
Gastrointestinal diseases, possible under anticoagulation and coagulopathies |
500 μg in a split dose |
– |
Groener et al.55. Groener JB, Lehnhoff D, Piel D, Nawroth PP, Schanz J, Rudofsky G. Subcutaneous application of levothyroxine as succesful treatment option in a patient with malabsorption. Am J Case Rep. 2013;14:48-51.
|
Case report |
Subcutaneous |
Malabsorption |
500 μg in one application site |
Painful local reaction due to application of entire dose to one place |
Nobre et al.44. Nobre EL, Jorge Z, Anselmo J, Lopes C, César R, Santos V, et al. A rare case of malabsorption of thyroid hormones. Acta Med Port. 2004;17(6):487-91.
|
Case report |
Weekly intravenous LT4 |
Non compliance, gastrointestinal disease |
300 μg of LT4 diluted in 50 mL of saline, weekly by intravenous infusion over 15 minutes |
– |
Nakano2222. Nakano Y. A case of refractory hypothyroidism due to poor compliance treated with weekly intravenous and oral levothyroxine administration. Case Reports in Endocrinology. 2019;5986014. doi: org/10.1155/2019/5986014 org/10.1155/2019/5986014...
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Case report |