The authors present the first list of vascular plants collected by them in the region of São José do Rio Preto county, State of São Paulo, Brazil. This list of 76 species includes 23 ones of cerrado (14 of these exclusively of cerrado), and 20 species of adventitious plants (arvenses or ruderales). The 76 species are distributed in 67 genera and 34 families. The climate of the county is mesothermic, tending to megathermic, corresponding to the Koppen's Cwa type. The predominant soil is a dark-red latosol, originated from decomposition of Arenito de Bauru (Bauru sandy soil of upper Cretaceous).