Symptoms of deficiencies of several macronutrients and binary combinations thereof were induced in the cotton plant. It was found that depending upon the particular combination the following picture developed: (a) individual symptoms are present according to the general pattern; (b) individual symptoms are present with a reversal of the general pattern with respect of distribution; (c) a combination of the individual symptoms shows up; (d) an individual symptom masks the other; (e) a different symptom develops. Chemical analysis of both upper and lower leaves has shown single and multiple effects depending upon the treatment considered.