Aloi M77. Aloi M, Lionetti P, Barabino A, Guariso G, Costa S, Fontana M, et al. Phenotype and disease course of early-onset pediatric inflammatory bowel disease. Inflamm Bowel Dis . 2014;20:597-605. doi: 10.1097/01.MIB.0000442921.77945.09. https://doi.org/10.1097/01.MIB.000044292...
2014, Italy, Multicentre Prospective |
2009-2013 |
506 |
245 (48.4%) |
224 (44.2%) |
37 (7.3%) |
- |
|
- |
Jakobsen C88. Jakobsen C, Cleynen I, Andersen PS, Vermeire S, Munkholm P, Paerregaard A, et al. Genetic susceptibility and genotype-phenotype association in 588 Danish children with inflammatory bowel disease. J Crohns Colitis . 2014;8:678-85. doi: 10.1016/j.crohns.2013.12.010. https://doi.org/10.1016/j.crohns.2013.12...
2014, Denmark, Multicentre Retrospective |
1982 onward |
588 |
318 (54%) |
244 (41.4%) |
26 (4.4%) |
10.9 years (9.3-14.5) |
54% |
4.7 years |
Hradsky O99. Hradsky O, Copova I, Zarubova K, Durilova M, Nevoral J, Maminak M, et al. Seroprevalence of Epstein-Barr Virus, Cytomegalovirus, and Polyomaviruses in Children with Inflammatory Bowel Disease. Dig Dis Sci. 2015;60:3399-407. 2015, Czech - Prague, Single-centre Prospective |
2014 |
106 |
31 (29.2%) |
72 (68%) |
3 (2.8%) |
- |
- |
- |
Urlep D1010. Urlep D, Blagus R, Orel R. Incidence Trends and Geographical Variability of Pediatric Inflammatory Bowel Disease in Slovenia: A Nationwide Study. Biomed Res Int. 2015;2015:921730. 2015, Slovenia, Multicentre Retrospective |
2002-2010 |
279 |
105 (37.6%) |
167 (59.8%) |
7 (2.5%) |
- |
57% |
- |
Oliva-Hemker M1111. Oliva-Hemker M, Hutfless S, Al Kazzi ES, Lerer T, Mack D, LeLeiko N, et al. Clinical Presentation and Five-Year Therapeutic Management of Very Early-Onset Inflammatory Bowel Disease in a Large North American Cohort. J Pediatr. 2015;167:527-32.e1-3. 2015, USA, Multicentre Prospective |
2002-2012 |
1928 |
513 (26.6%) |
1305 67.7% |
110 (5.7%) |
- |
|
3.25 years |
Cakir M1212. Cakir M, Unal F, Dinler G, Baran M, Yuksekkaya HA, Tumgor G, et al. Inflammatory bowel disease in Turkish children. World J Pediatr. 2015;11:331-7. 2015, Turkey, Multicentre Retrospective |
2004-2012 |
127 |
90 (70.9%) |
29 22.8 |
8 (6.3%) |
10.5±5.7 years |
50% |
- |
Buderus S1313. Buderus S, Scholz D, Behrens R, Classen M, De Laffolie J, Keller KM, et al. Inflammatory bowel disease in pediatric patients: Characteristics of newly diagnosed patients from the CEDATA-GPGE Registry. Dtsch Arztebl Int. 2015;112:121-7. 2015, Germany and Austria, Multicentre Prospective |
2004-2014 |
958 |
278 (29%) |
616 64.3 |
64 (6.7%) |
11.9 years (0.4-17.6) |
51.5% |
- |
Arcos-Machancoses JV1414. Arcos-Machancoses JV, Donat-Aliaga E, Polo-Miquel B, Masip-Simó E, Ribes-Koninckx C, Pereda-Pérez A. Retraso diagnóstico en la enfermedad inflamatoria intestinal pediátrica. Descripción y estudio de los factores de riesgo [Description and study of risk factors for the diagnostic delay of pediatric inflammatory bowel disease]. An Pediatr (Barc). 2015;82:247-54. 2015, Spain, Single-centre Retrospective |
2000-2012 |
53 |
19 (35.8%) |
31 (58.4%) |
3 (5.7%) |
- |
- |
- |
Dimakou K1515. Dimakou K, Pachoula I, Panayotou I, Stefanaki K, Orfanou I, Lagona E, et al. Pediatric inflammatory bowel disease in Greece: 30-years experience of a single center. Ann Gastroenterol. 2015;28:81-6. 2015, Greece, Single-centre Retrospective |
1981-2011 |
483 |
267 (55.2%) |
167 (34.5%) |
49 (10%) |
8.9 years (4.8-13.7) |
38.6% |
- |
Schwarz J1616. Schwarz J, Sýkora J, Cvalínová D, Pomahačová R, Klečková J, Kryl M, et al. Inflammatory bowel disease incidence in Czech children: A regional prospective study, 2000-2015. World J Gastroenterol. 2017;23:4090-4101 2017, Czech - Pilsen, Multicentre Prospective |
2000-2015 |
170 |
48 (28.2%) |
105 (61.7%) |
17 (10%) |
14.1 years (2.5-17.7) |
53% |
- |
Paul SP1717. Paul SP, Sandhu BK. Long-term Outcome of Inflammatory Bowel Disease-Unclassified in Children. Indian Pediatr. 2017;54:742-5. 2017, UK, Single-centre Retrospective |
2004-2011 |
344 |
119 (34.5%) |
199 (58%) |
26 (7.5%) |
10.1 years (1.4-16.1) |
64% |
51(34-87) months |
Lopez RN1818. Lopez RN, Evans HM, Appleton L, Bishop J, Chin S, Mouat S, et al. Point Prevalence of Pediatric Inflammatory Bowel Disease in New Zealand in 2015: Initial Results from the PINZ Study. Inflamm Bowel Dis . 2017;23:1418-24. 2017, New Zealand, Multicentre Retrospective |
2015 |
212 |
32 (15.1%) |
161 (75.9%) |
19 (9%) |
12.7 years (9.5-14.0) |
68.4% |
- |
El Mouzan MI1919. El Mouzan MI, Al Mofarreh MA, Al Sarkhy AA, Assiri AM, Hamed YM. Pre-illness diet as risk factor in pediatric inflammatory bowel disease in Saudi Arabia. Saudi J Gastroenterol. 2017;23:287-90. 2017, Saudi, Single-centre Prospective |
- |
52 |
14 (27%) |
38 (73%) |
0 |
- |
- |
- |
Bequet E2020. Bequet E, Sarter H, Fumery M, Vasseur F, Armengol-Debeir L, Pariente B, et al. Incidence and Phenotype at Diagnosis of Very-early-onset Compared with Later-onset Paediatric Inflammatory Bowel Disease: A Population-based Study [1988-2011]. J Crohns Colitis . 2017;11:519-26. 2017, France, Multicentre Prospective |
1988-2011 |
1412 |
343 (24.2%) |
1032 (73.1%) |
37 (2.6%) |
- |
- |
- |
Rinawi F55. Rinawi F, Assa A, Eliakim R, Mozer-Glassberg Y, Nachmias Friedler V, Niv Y, et al. The natural history of pediatric-onset IBD-unclassified and prediction of Crohn’s disease reclassification: a 27-year study. Scand J Gastroenterol. 2017;52:558-63. 2017, Israel, Single-centre Retrospective |
1986-2013 |
723 |
188 (26%) |
482 (66.6%) |
53 (7.3%) |
12.8 years (9.5-15.6) |
56.6% |
6.8 years |
Ong C2121. Ong C, Aw MM, Liwanag MJ, Quak SH, Phua KB. Rapid rise in the incidence and clinical characteristics of pediatric inflammatory bowel disease in a South-East Asian cohort in Singapore, 1994-2015. J Dig Dis. 2018;19:395-403. doi: 10.1111/1751-2980.12641. https://doi.org/10.1111/1751-2980.12641...
2018, Sinagpore, Multicentre Retrospective |
1994-2015 |
228 |
69 (30.3%) |
139 (61%) |
20 (8.7%) |
13.1 years (IQR 5.53) |
45% |
- |
Chandradevan R2222. Chandradevan R, Hofmekler T, Mondal K, Harun N, Venkateswaran S, Somineni HK, et al. Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles. Inflamm Bowel Dis . 2018;24:2285-90. 2018, United States and Canada, Multicentre Prospective |
2008-2012 |
1411 |
- |
- |
136 (9.6%) |
12.51±3.64 years |
57.3% |
2 years |
Ziade F2323. Ziade F, Rungoe C, Kallemose T, Paerregaard A, Wewer AV, Jakobsen C. Biochemical Markers, Genotype, and Inflammation in Pediatric Inflammatory Bowel Disease: A Danish Population-Based Study. Dig Dis. 2019;37:140-6. 2019, Denmark, Multicentre Retrospective |
1998-2006 |
235 |
112 (47.6%) |
108 (46%) |
15 (6.4%) |
8.6 years (3.1-13.5) |
80% |
- |
Harris RE2424. Harris RE, Sim W, Sutton H, Garrick V, Curtis L, Gervais L, et al. Using a Steroid-sparing Tool in Paediatric Inflammatory Bowel Disease to Evaluate Steroid Use and Dependency. J Pediatr Gastroenterol Nutr . 2019;69:557-63. 2019, Scotland, Single-centre Retrospective |
2017-2018 |
229 |
31 (13.5%) |
181 (79%) |
17 (7.4%) |
- |
- |
- |
Ashton JJ2525. Ashton JJ, Borca F, Mossotto E, Coelho T, Batra A, Afzal NA, et al. Increased prevalence of anti-TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood. Aliment Pharmacol Ther. 2019;49:398-407. 2019, UK, Single-centre Prospective |
1997-2017 |
825 |
272 (32.9%) |
498 (60.3%) |
55 (6.6%) |
- |
- |
- |
Zhang R2626. Zhang R, Zhong XM, Gong YZ, Ma X, Zhu D, Ning HJ, et al. [Analysis of clinical characteristics and drug treatment of inflammatory bowel disease in children: a single center study]. Zhonghua Er Ke Za Zhi. 2020;58:570-5. 2020, China, Single-centre Retrospective |
2009-2018 |
87 |
25 (29%) |
50 (57%) |
12 (14%) |
- |
- |
- |
Ivković L2727. Ivković L, Hojsak I, Trivić I, Sila S, Hrabač P, Konjik V, et al. Incidence and Geographical Variability of Pediatric Inflammatory Bowel Disease in Croatia: Data From the Croatian National Registry for Children With Inflammatory Bowel Disease. Clin Pediatr (Phila). 2020;59:1182-90. 2020, Croatia, Multicentre Prospective |
2016-2017 |
51 |
28 (56%) |
19 (38%) |
8 (15.6) |
14.5 years (12.8-16.7) |
75% |
- |
Mouratidou N2828. Mouratidou N, Malmborg P, Sachs MC, Askling J, Ekbom A, Neovius M, et al. Adult height in patients with childhood-onset inflammatory bowel disease: a nationwide population-based cohort study. Aliment Pharmacol Ther . 2020;51:789-800. 2020, Sweden, Multicentre Retrospective |
1990-2014 |
4201 |
2201 (52.3%) |
1640 (39%) |
360 (8.5%) |
- |
- |
Range 1.3 to 27.2 years |
Dhaliwal J2929. Dhaliwal J, Walters TD, Mack DR, Huynh HQ, Jacobson K, Otley AR, et al. Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network. J Crohns Colitis . 2020;14:445-54. 2020, Canada, Multicentre Prospective |
2014-2017 |
1092 |
316 (30%) |
687 (62%) |
89 (8%) |
- |
- |
1 year |
Arai K3030. Arai K, Kunisaki R, Kakuta F, Hagiwara SI, Murakoshi T, Yanagi T, et al. Phenotypic characteristics of pediatric inflammatory bowel disease in Japan: results from a multicenter registry. Intest Res. 2020;18:412-20. 2020, Japan, Multicentre Prospective |
2012-2015 |
243 |
146 (60.1%) |
91 (37.4%) |
6 (2.4%) |
4.3±5.6 years |
50% |
- |
Larrosa-Haro A3131. Larrosa-Haro A, Abundis-Castro L, Contreras MB, Gallo MJ, Peña-Quintana L, Targa Ferreira CH, et al. Epidemiologic trend of pediatric inflammatory bowel disease in Latin America: The Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN) Working Group. Rev Gastroenterol Mex (Engl Ed). 2021;86:328-34. 2020, Latin America - 9 Countries, Multicentre Retrospective |
2005-2016 |
607 |
475 (78.3%) |
104 (17.1%) |
28 (4.6%) |
- |
|
- |
Srivastava A3232. Srivastava A, Sathiyasekharan M, Jagadisan B, Bolia R, Peethambaran M, Mammayil G, et al. Paediatric inflammatory bowel disease in India: a prospective multicentre study. Eur J Gastroenterol Hepatol. 2020;32:1305-11. 2020, India, Multicentre Ambispective |
2016-2019 |
325 |
91 (28%) |
212 (65.2%) |
22 (6.7%) |
3.3 years (IQR 2.3) |
67% |
- |