Wu 20023737. Wu MS, Huang SP, Chang YT, Shun CT, Chang MC, Lin MT, Wang HP, Lin JT. Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma. J Infect Dis. 2002;185:106-9.
|
China (Asian) |
150 |
220 |
135 |
14 |
1 |
284 |
16 |
208 |
11 |
1 |
427 |
13 |
0.029 |
0.057 |
Wu 20033838. Wu MS, Wu CY, Chen CJ, Lin MT, Shun CT, Lin JT. Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J Cancer. 2003;104:617-23.
|
China (Asian) |
220 |
230 |
195 |
23 |
2 |
413 |
27 |
217 |
11 |
2 |
445 |
15 |
0.032 |
0.002 |
El-Omar 20034848. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 2003;124:1193-201.
|
USA (Caucasian) |
314 |
210 |
120 |
133 |
61 |
373 |
255 |
59 |
103 |
48 |
221 |
199 |
0.473 |
0.812 |
Savage 20043434. Savage SA, Abnet CC, Haque K, Mark SD, Qiao YL, Dong ZW, Dawsey SM, Taylor PR, Chanock SJ. Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk Chinese population. Cancer Epidemiol Biomarkers Prev. 2004;13:1547-9.
|
China (Asian) |
84 |
382 |
4 |
20 |
60 |
28 |
140 |
20 |
81 |
284 |
120 |
644 |
0.842 |
≤0.001 |
Lee 20052828. Lee JY, Kim HY, Kim KH, Kim SM, Jang MK, Park JY, Lee JH, Kim JH, Yoo JY. Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea. Cancer Lett. 2005;225:207-14.
|
Korea (Asian) |
122 |
120 |
104 |
17 |
1 |
225 |
19 |
101 |
18 |
1 |
220 |
20 |
0.083 |
0.842 |
Lu 20053030. Lu W, Pan K, Zhang L, Lin D, Miao X, You W. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor a and risk of gastric cancer in a Chinese population. Carcinogenesis. 2005;26:631-6.
|
China (Asian) |
250 |
300 |
201 |
43 |
6 |
445 |
55 |
268 |
29 |
3 |
565 |
35 |
0.058 |
0.037 |
Guo 20054242. Guo W, Wang N, Wang YM, Li Y, Wen DG, Chen ZF, He YT, Zhang JH. Interleukin-10 -1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China. World J Gastroenterol. 2005;11:858-62.
|
China (Asian) |
179 |
443 |
93 |
56 |
3 |
285 |
73 |
267 |
164 |
12 |
698 |
188 |
0.212 |
0.023 |
Zambon 20055252. Zambon CF, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, et al. Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine. 2005;29:141-52.
|
Italy (Caucasian) |
120 |
644 |
48 |
56 |
25 |
141 |
99 |
232 |
326 |
86 |
790 |
498 |
0.386 |
0.087 |
Alpízar-Alpízar 20055353. Alpízar-Alpízar W, Pérez-Pérez GI, Une C, Cuenca P, Sierra R. Association of interleukin-1B and interleukin- 1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica. Clin Exp Med. 2005;5:169-76.
|
Costa Rica (Latinos) |
45 |
44 |
45 |
0 |
0 |
90 |
0 |
43 |
1 |
0 |
87 |
1 |
0.011 |
0.939 |
Morgan 20063232. Morgan DR, Dominguez RL, Keku TO, Heidt PE, Martin CF, Galanko JA, et al. Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter. Clin Gastroenterol Hepatol. 2006;4:1103-11.
|
Honduras (Latinos) |
170 |
162 |
121 |
42 |
7 |
284 |
56 |
101 |
49 |
11 |
253 |
71 |
0.220 |
0.145 |
Kamangar 20065151. Kamangar F, Abnet CC, Hutchinson AA, Newschaffer CJ, Helzlsouer K, Shugart YY, et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control. 2006;17:117-25.
|
Finland (Caucasian) |
112 |
208 |
38 |
47 |
27 |
123 |
101 |
72 |
96 |
37 |
244 |
172 |
0.414 |
0.613 |
Sugimoto 20073636. Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Sugimura H, Hishida A. Effects of interleukin- 10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. J Gastroenterol Hepatol. 2007;22:1443-9.
|
Japan (Asian) |
105 |
168 |
78 |
26 |
0 |
184 |
26 |
134 |
34 |
0 |
302 |
34 |
0.101 |
0.144 |
García 20075050. García-González MA, Lanas A, Quintero E, Nicolás D, Parra-Blanco A, Strunk M, et al Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol. 2007;102:1878-92.
|
Spain (Caucasian) |
404 |
404 |
123 |
204 |
77 |
450 |
358 |
133 |
189 |
82 |
455 |
353 |
0.436 |
0.322 |
Bai 20084040. Bai XL, Sun LP, Liu J, Chen W, Zhang Y, Yuan Y. [Correlation of interleukin-10-1082G/A single nucleotide polymorphism to the risk of gastric cancer in North China: a case-control study]. [Article in Chinese]. Ai Zheng. 2008;27:35-40.
|
China (Asian) |
111 |
111 |
89 |
22 (AG+GG) |
- |
- |
104 |
7 (AG+GG) |
- |
- |
- |
- |
Forte 20084949. Forte GI, Calà C, Scola L, Crivello A, Gullo A, Marasà L, et al. Role of environmental and genetic factor interaction in age-related disease development: the gastric cancer paradigm. Rejuvenation Res. 2008;11:509-12.
|
Italy (Caucasian) |
42 |
185 |
21 |
16 |
5 |
58 |
26 |
83 |
66 |
36 |
235 |
135 |
0.364 |
≤0.001 |
Kang 20094444. Kang JM, Kim N, Lee DH, Park JH, Lee MK, Kim JS, et al. The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. J Clin Gastroenterol. 2009;43:420-8.
|
Korea (Asian) |
335 |
335 |
281 |
49 |
4 |
613 |
57 |
289 |
35 |
0 |
634 |
36 |
0.054 |
0.304 |
Ko 20092525. Ko KP, Park SK, Cho LY, Gwack J, Yang JJ, Shin A, et al. Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk. J Nutr. 2009;139:1008-12.
|
Korea (Asian) |
84 |
336 |
67 |
12 |
1 |
153 |
15 |
276 |
35 |
1 |
632 |
40 |
0.059 |
0.921 |
Xiao 20093939. Xiao H, Jiang Y, Li R, Xia B. Association of IL-10 gene polymorphisms with gastroduodenal diseases in Hubei Han population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:423-6.
|
China (Asian) |
220 |
624 |
176 |
41 |
3 |
393 |
47 |
593 |
31 |
0 |
1208 |
40 |
0.032 |
0.524 |
Zhou 20084646. Zhou SZ, Zhu WL, Li MY, Li HY, Zhang JR. [Association of single nucleotide polymorphism at interleukin-10 gene 1082 nt with the risk of gastric cancer in Chinese population]. [Article in Chinese]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28:1335-8.
|
China (Asian) |
150 |
150 |
29 |
62 |
59 |
120 |
180 |
52 |
53 |
45 |
157 |
143 |
0.476 |
≤0.001 |
Shin 20113535. Shin CM, Kim N, Lee HS, Lee DH, Kim JS, Jung HC, Song IS. Intrafamilial aggregation of gastric cancer: a comprehensive approach including environmental factors, Helicobacter pylori virulence, and genetic susceptibility. Eur J Gastroenterol Hepatol. 2011;23:411-7.
|
Korea (Asian) |
632 |
237 |
534 |
91 |
7 |
1159 |
105 |
199 |
38 |
0 |
436 |
38 |
0.080 |
0.179 |
Liu 20112929. Liu J, Song B, Wang JL, Li ZJ, Li WH, Wang ZH. Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer. World J Gastroenterol. 2011;17:1362-7.
|
China (Asian) |
234 |
243 |
189 |
39 |
6 |
417 |
51 |
217 |
23 |
3 |
457 |
29 |
0.059 |
0.014 |
He 20124343. He B, Pan Y, Xu Y, Nie Z, Chen L, Gu L, Wang S. Increased risk for gastric cancer in carriers of the lymphotoxin- a+252G variant infected by Helicobacter pylori. Genet Test Mol Biomarkers. 2012;16:9-14.
|
China (Asian) |
196 |
248 |
154 |
42 |
0 |
350 |
42 |
194 |
54 |
0 |
442 |
54 |
0.108 |
0.054 |
Zeng 20124545. Zeng X, Li Y, Liu T, Zhang J. Diverse H. pylori strains, IL-10 promoter polymorphisms with high morbidity of gastric cancer in Hexi area of Gansu Province, China. Mol Cell Biochem. 2012;362:241-8.
|
China (Asian) |
151 |
153 |
27 |
60 |
64 |
114 |
188 |
48 |
53 |
52 |
149 |
157 |
0.513 |
≤0.001 |
Kim 20122323. Kim J, Cho YA, Choi IJ, Lee YS, Kim SY, Shin A, et al. Effects of interleukin-10 polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer. PLoS One. 2012;7:e29643.
|
Korea (Asian) |
495 |
495 |
416 |
72 |
7 |
904 |
86w |
435 |
56 |
1 |
932 |
58 |
0.058 |
0.564 |
Chand‐Bhayal 20124141. Chand-Bhayal A, Krishnaveni D, Pandu-Ranga-Rao K, Prabhakar B, Vidyasagar A, Murali-Krishna B, et al. Association of interleukin-10 promoter polymorphism (-1082 g/a) and gastric cancer in andhra pradesh population of South India. Iran J Cancer Prev. 2012;5:117-23.
|
India (Asian) |
100 |
132 |
47 |
35 |
18 |
129 |
71 |
40 |
50 |
42 |
130 |
134 |
0.507 |
0.005 |
Pan 20133333. Pan XF, Yang SJ, Loh M, Xie Y, Wen YY, Tian Z, et al. Interleukin-10 gene promoter polymorphisms and risk of gastric cancer in a Chinese population: single nucleotide and haplotype analyses. Asian Pac J Cancer P. 2013;14:2577-82.
|
China (Asian) |
308 |
308 |
263 |
41 |
4 |
567 |
49 |
264 |
41 |
3 |
596 |
47 |
0.076 |
0.329 |
Kuo 20142727. Kuo WH, Huang CY, Fu CK, Hsieh YH, Liao CH, Hsu CM, Huang YK, Tsai CW, Chang WS, Bau DT. Effects of www.impactjournals.com/oncotarget 18 Oncotarget interleukin-10 polymorphisms and smoking on the risk of gastric cancer in Taiwan. In Vivo. 2014;28:967-71.
|
Taiwan (Asian) |
358 |
358 |
235 |
101 |
22 |
571 |
145 |
281 |
67 |
10 |
629 |
87 |
0.121 |
0.019 |
Hormazabal 20145454. Gonzalez-Hormazabal P, Musleh M, Bustamante M, Stambuk J, Escandar S, Valladares H, et al. Role of cytokine gene polymorphisms in gastric cancer risk in Chile. Anticancer Res. 2014;34:3523-30.
|
Chile (Latinos) |
147 |
172 |
79 |
54 |
14 |
212 |
82 |
88 |
71 |
13 |
247 |
97 |
0.282 |
0.799 |
Burada 20104747. Burada F, Angelescu C, Ioana M, Mitrut P, Moraru E, Riza A, et al. IL-10 -1082 A/G polymorphism and risk of gastric cancer. Annals of RSCB; 2010. Vol. XV, Issue 1.
|
Romania (Caucasian) |
63 |
78 |
9 |
54 |
0 |
72 |
54 |
12 |
66 |
0 |
90 |
66 |
0.423 |
≤0.001 |
Kumar 20152626. Kumar S, Kumari N, Mittal RD, Mohindra S, Ghoshal UC. Association between pro-(IL-8) and anti-inflammatory (IL-10) cytokine variants and their serum levels and H. pylori-related gastric carcinogenesis in northern India. Meta Gene. 2015;6:9-16.
|
India (Asian) |
200 |
250 |
74 |
96 |
30 |
244 |
156 |
85 |
122 |
43 |
464 |
36 |
0.071 |
0.945 |