Sheikh, 19971919. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med. 1997;157:913-9. |
F/59 |
Chaparral capsules |
1800 mg |
52 |
Abdominal pain, nausea/vomiting, jaundice, dark urine, light stools |
ALT, AST, ALP, TB |
Cholestatic |
Transplant |
Chow, 20082020. Chow EC, Teo M, Ring JA, Chen JW. Liver failure associated with the use of black cohosh for menopausal symptoms. Med J Aust. 2008;188:420-2. http://doi.org/10.5694/j.1326-5377.2008.tb01691.x. https://doi.org/10.5694/j.1326-5377.2008...
|
F/51 |
Preparation of black cohosh |
40 mg |
8 |
Weakness, nausea/vomiting, jaundice, ascites |
ALT, AST, ALP, GGT, TB |
Hepatocellular |
Transplant |
Lynch, 20062121. Lynch CR, Folkers ME, Hutson WR. Fulminant hepatic failure associated with the use of black cohosh: a case report. Liver Transpl. 2006;12:989-92. http://doi.org/10.1002/lt.20778. https://doi.org/10.1002/lt.20778...
|
F/54 |
Black Cohosh |
1000 mg |
34 |
Weakness, encephalopathy |
ALT, AST, ALP, GGT, TB |
Mixed |
Death |
Jung, 20112222. Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, et al. Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb. Gut Liver. 2011;5:493-9. http://doi.org/10.5009/gnl.2011.5.4.493. https://doi.org/10.5009/gnl.2011.5.4.493...
|
M/57 |
Polygonum multiflorum |
UN |
4 |
Fever, jaundice, encephalopathy |
ALT, ALP, TB |
Mixed |
Death |
Jung, 20112222. Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, et al. Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb. Gut Liver. 2011;5:493-9. http://doi.org/10.5009/gnl.2011.5.4.493. https://doi.org/10.5009/gnl.2011.5.4.493...
|
M/24 |
Polygonum multiflorum |
UN |
2 |
Jaundice |
ALT, ALP, TB |
Hepatocellular |
Transplant |
Becker, 20192323. Becker MW, Lourencone EMS, De Mello AF, Branco A, Rodrigues Filho EM, Blatt CR, et al. Liver transplantation and the use of KAVA: Case report. Phytomedicine. 2019;56:21-6. http://doi.org/10.1016/j.phymed.2018.08.011. https://doi.org/10.1016/j.phymed.2018.08...
|
F/45 |
Kava herb |
100 mg |
7 |
Nausea/vomiting, Jaundice, encephalopathy |
ALT, AST, TB |
Hepatocellular |
Transplant |
Campo, 20022424. Campo JV, McNabb J, Perel JM, Mazariegos GV, Hasegawa SL, Reyes J. Kava-induced fulminant hepatic failure. J Am Acad Child Adolesc Psychiatry. 2002;41:631-2. http://doi.org/ 10.1097/00004583-200206000-00001. https://doi.org/10.1097/00004583-2002060...
|
F/14 |
Preparation of Kava |
NI |
13 |
Nausea/vomiting, weakness |
ALT, AST, GGT, TB |
Hepatocellular |
Transplant |
MMWR, 20022525. Centers for Disease Control (CDC). Chaparral-induced toxic hepatitis-California and Texas, 1992. MMWR Morb Mortal Wkly Rep. 1992;41:812-4. http://doi.org/10.1097/00004583-200206000-00001. https://doi.org/10.1097/00004583-2002060...
|
F/14 |
Kava Products |
4 caps |
17 |
Nausea/vomiting, jaundice, weakness |
ALT, AST, GGT, TB |
Hepatocellular |
Transplant |
Escher, 20012626. Escher M, Desmeules J, Giostra E, Mentha G. Hepatitis associated with Kava, a herbal remedy for anxiety. BMJ. 2001;322:139. http://doi.org/10.1136/bmj.322.7279.139. https://doi.org/10.1136/bmj.322.7279.139...
|
M/50 |
Capsules of kava extracts |
4 caps |
8 |
Jaundice, weakness, dark urine, encephalopathy |
ALT, AST, ALP, GGT, TB |
Hepatocellular |
Transplant |
Teschke, 20082727. Teschke R, Schwarzenboeck A, Hennermann KH. Kava hepatotoxicity: a clinical survey and critical analysis of 26 suspected cases. Eur J Gastroenterol Hepatol. 2008;20:1182-93. http://doi.org/10.1097/MEG.0b013e3283036768. |
F/60 |
Kava extract |
UN |
52 |
Abdominal pain, jaundice, weakness |
UN |
Mixed |
Transplant |
Teschke, 20082727. Teschke R, Schwarzenboeck A, Hennermann KH. Kava hepatotoxicity: a clinical survey and critical analysis of 26 suspected cases. Eur J Gastroenterol Hepatol. 2008;20:1182-93. http://doi.org/10.1097/MEG.0b013e3283036768. |
M/50 |
Kava extract |
UN |
8 |
Abdominal pain, jaundice, weakness |
UN |
Hepatocellular |
Transplant |
Fong, 20102828. Fong TL, Klontz KC, Canas-Coto A, Casper SJ, Durazo FA, Davern TJ, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol . 2010;105:1561-6. http://doi.org/10.1038/ajg.2010.5. https://doi.org/10.1038/ajg.2010.5...
|
M/20 |
Hydroxycut |
UN |
13 |
Nausea/vomiting, jaundice, weakness, encephalopathy |
ALT, AST, TB |
UN |
Death |
Fong, 20102828. Fong TL, Klontz KC, Canas-Coto A, Casper SJ, Durazo FA, Davern TJ, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol . 2010;105:1561-6. http://doi.org/10.1038/ajg.2010.5. https://doi.org/10.1038/ajg.2010.5...
|
NI/NI |
Hydroxycut |
UN |
52 |
Nausea/vomiting |
ALT, AST, ALP, TB |
Hepatocellular |
Transplant |
Fong, 20102828. Fong TL, Klontz KC, Canas-Coto A, Casper SJ, Durazo FA, Davern TJ, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol . 2010;105:1561-6. http://doi.org/10.1038/ajg.2010.5. https://doi.org/10.1038/ajg.2010.5...
|
NI/NI |
Hydroxycut |
UN |
8 |
Abdominal pain, nausea/vomiting, weakness |
ALT, AST, ALP, TB |
Hepatocellular |
Transplant |
Fong, 2010 (28) |
NI/NI |
Hydroxycut |
UN |
4 |
Nausea/vomiting, weakness |
ALT, AST, ALP, TB |
Hepatocellular |
Transplant |
Elinav, 20072929. Elinav E, Pinsker G, Safadi R, Pappo O, Bromberg M, Anis E, et al. Association between consumption of Herbalife nutritional supplements and acute hepatotoxicity. J Hepatol. 2007;47:514-20. http://doi.org/10.1016/j.jhep.2007.06.016. https://doi.org/10.1016/j.jhep.2007.06.0...
|
F/33 |
Protein mix drink, Herbalifeline (fish oil concentrate), Thermojetics herbal mix (tea), Thermojetics Green and beige capsules (herbal extract), Tang Kuei Plus, Instant drink with plant extracts, Sesame and Herbs tablets, Safflower oil capsules |
UN |
13 |
Jaundice, weakness |
UN |
Hepatocellular |
Transplant |
Favreau, 20023030. Favreau JT, Ryu ML, Braunstein G, Orshansky G, Park SS, Coody GL, et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med. 2002;136:590-5. http://doi.org/10.7326/0003-4819-136-8-200204160-00008. https://doi.org/10.7326/0003-4819-136-8-...
,3131. Scott BA, Troppmann C, Rossaro L. Hepatotoxicity associated with a dietary supplement. Ann Intern Med . 2003;138:49. http://doi.org/10.7326/0003-4819-138-8-200304150-00035-w1. https://doi.org/10.7326/0003-4819-138-8-...
|
F/20 |
Lipokinetix |
UN |
2 |
Abdominal pain, fever, jaundice, encephalopathy |
ALT, AST, TB |
Hepatocellular |
Transplant |
Scott, 20033232. Neff GW, Reddy KR, Durazo FA, Meyer D, Marrero R, Kaplowitz N. Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol. 2004;41:1062-4. http://doi.org/10.1016/j.jhep.2004.06.028. https://doi.org/10.1016/j.jhep.2004.06.0...
|
F/24 |
Lipokinetix |
UN |
13 |
Nausea/vomiting, jaundice, encephalopathy |
ALT, AST, TB |
Hepatocellular |
Transplant |
Neff, 20043333. Foley S, Butlin E, Shields W, Lacey B. Experience with OxyELITE pro and acute liver injury in active duty service members. Dig Dis Sci. 2014;59:3117-21. http://doi.org/10.1007/s10620-014-3221-4. https://doi.org/10.1007/s10620-014-3221-...
|
F/32 |
Lipokinetix |
UN |
2 |
UN |
ALT, AST, TB |
Hepatocellular |
Transplant |
Foley, 2014 (34) |
F/45 |
OxyELITE Pro |
UN |
104 |
Jaundice, weakness, encephalopathy |
ALT, AST, ALP, TB |
UN |
Transplant |
Foley, 20143434. Roytman MM, Porzgen P, Lee CL, Huddleston L, Kuo TT, Bryant-Greenwood P, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol . 2014;109:1296-8. http://doi.org/10.1038/ajg.2014.159. https://doi.org/10.1038/ajg.2014.159...
|
M/28 |
OxyELITE Pro |
UN |
8 |
Jaundice, weakness encephalopathy |
ALT, AST, TB |
UN |
Transplant |
Roytman, 2014 (35) |
M/22 |
New OxyElite Pro |
UN |
2 |
Abdominal pain, nausea/vomiting, jaundice, weakness, encephalopathy |
ALT, ALP, TB |
UN |
Transplant |
Roytman, 20143535. Johnston DI, Chang A, Viray M, Chatham-Stephens K, He H, Taylor E, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8:319-27. http://doi.org/10.1002/dta.1894. https://doi.org/10.1002/dta.1894...
|
F/48 |
New OxyElite Pro |
UN |
4 |
Abdominal pain, nausea/vomiting encephalopathy |
ALT, ALP, TB |
UN |
Death |
Johnston, 20163636. Heidemann LA, Navarro VJ, Ahmad J, Hayashi PH, Stolz A, Kleiner DE, Fontana RJ. Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series. Dig Dis Sci . 2016;61:2741-8. http://doi.org/10.1007/s10620-016-4181-7. https://doi.org/10.1007/s10620-016-4181-...
|
F/42 |
New OxyELITE Pro |
UN |
UN |
Nausea/vomiting, encephalopathy |
ALT, AST, ALP, TB |
UN |
Death |
Roytman, 20143535. Johnston DI, Chang A, Viray M, Chatham-Stephens K, He H, Taylor E, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8:319-27. http://doi.org/10.1002/dta.1894. https://doi.org/10.1002/dta.1894...
|
F/31 |
New OxyElite Pro; Garcinia Cambogia; Cellucor Super HD; HCA Supreme |
UN |
4 |
Nausea/vomiting weakness, jaundice, encephalopathy |
ALT, ALP, TB |
UN |
Transplant |
Heidemann, 20163636. Heidemann LA, Navarro VJ, Ahmad J, Hayashi PH, Stolz A, Kleiner DE, Fontana RJ. Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series. Dig Dis Sci . 2016;61:2741-8. http://doi.org/10.1007/s10620-016-4181-7. https://doi.org/10.1007/s10620-016-4181-...
|
F/46 |
OxyELITE Pro; Stacker |
1 cap |
17 |
Jaundice |
ALT, ALP, TB |
Hepatocellular |
Transplant |
Heidemann, 2016 (36) |
M/36 |
OxyELITE Pro; Ravage; Hydroxycut |
3 cap |
31 |
Jaundice |
ALT, ALP, TB |
Hepatocellular |
Transplant |
Sheikh, 19971919. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med. 1997;157:913-9. |
F/38 |
Chaparral capsules; multivitamins; folic acid; calcium |
UN |
UN |
UN |
TB |
UN |
Transplant |
Perera, 20133737. Perera NJ, Steinbeck KS, Shackel N. The adverse health consequences of the use of multiple performance-enhancing substances--a deadly cocktail. J Clin Endocrinol Metab. 2013;98:4613-8. http://doi.org/10.1210/jc.2013-2310. https://doi.org/10.1210/jc.2013-2310...
|
M/35 |
anabolic steroid; T propionate; nandrolone decanoate, L-glutamine; leucine, protein powder; vitamin C; zinc |
UN |
UN |
Abdominal pain, Nausea/vomiting, jaundice, pruritus |
AST, ALT, ALP, GGT, TB |
Mixed |
Death |