ABSTRACT
For the storage and shipment of inactivated rabies vaccines, the recommended temperature is 2º to 8ºC (36º to 46ºF) . Forty-eight bovines were vaccinated with commercial rabies vaccines that had been stored either refrigerated or frozen. Neutralizing antibody (SN) titers, prior to vaccination at day 0 were < 5. Thirty days later, titers of animals vaccinated with vaccine-1, either refrigerated or frozen, ranged 11-439. At day 180, with vaccine-1, refrigerated, the maximum titer had decreased to 11, and to 8 at day 360. At day 30, animals vaccinated with frozen vaccine-1 presented titers ranging from 6-279; and at day 180 and 360, titers had decreased markedly. With refrigerated or frozen vaccine-2, at day 30, varying degrees of titers > 5 were detected, and two animals showed no response. With vaccine-2, refrigerated, three sera elicited titers at day 180, and at day 360, only one was reactant. With vaccine-2, frozen, at day 180 and 360, titers were < 5. The Anova test indicated that responses to either refrigerated or frozen vaccines were serologically similar, however, by the Tukey-Kramer test, significant results were found for the day 180, between vaccine-1, frozen X vaccine-2, frozen, and vaccine-1, refrigerated X vaccine-2, frozen (p < 0.01). The frozen avridineadjuvanted vaccine-1 enabled detectable levels of antibody for a longer period than the other vaccines.
KEY WORDS:
Rabies vaccines; bovines; storage temperature; refrigeration; freezing; neutralizing antibody.
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