Report of 4 cases of vertebral myeloma with invasion of the epidural space and root cord compression. In case 2 there was multiple bone lesions; in case 3 there was, besides the vertebral myeloma, a destructive lesion of the 8th right rib; the other cases probably were instances of the solitary form of the disease. The vertebral myelomas were localized between C7 and T9, in the four cases; in none of the cases there was involvement of the subdural space. In 3 cases the neurological picture was that of a sensory-motor paraplegia; in case 4 radiculalgic symptoms prevailed over the spinal ones. The following laboratory data are stressed: Bence-Jones proteinuria was evidenced only in the case of multiple myelomatosis; bone marrow puncture of the sternum was carried out in three cases, plasmocytosis being found only in case 2; in this patient with disseminated illness it was also shown decrease of blood cholesterol, raised concentration of uric acid in blood and positiveness of some liver function tests; electrophoresis of plasma proteins, carried out only in case 4, evidenced decrease of albumin and slight increase of α1 and α2 globulin fractions; the cerebrospinal fluid examination always showed increase of protein contents and spinal block; this latter and its level were confirmed by iodizedoil perimyelography, though it suggested an intraspinal tumor in case 1. The patients were treated by laminectomy and withdrawal of the tumoral invasive tissue, complemented by roentgentherapy in doses varying between 2,880 and 4,000 r. Results were very encouraging in all but one patient, who died a year later with multiple bone lesions.