Starr et al.2323. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016 Dec 5;5(1):210. https://doi.org/10.1186/s13643-016-0384-4 https://doi.org/10.1186/s13643-016-0384-...
, 2005 |
Individuals with DS and severe intellectual disability |
13 |
7 to 31 |
Autism Diagnostic Interview-Revised (ADI-R) and Adapted Pre-Linguistic Autism Diagnostic Observation Schedule (A-PL-ADOS) |
Parents |
DSM-IV and CID-10 |
- |
1.16:1 |
Carter et al.2424. Ortiz B, Videla L, Gich I, Alcacer B, Torres D, Jover I, Videla S. Early warning signs of autism spectrum disorder in people with Down syndrome. Int Med Rev Down Syndr. 2017 Jan-Apr;21(1):3-11. https://doi.org/10.1016/j.sdeng.2017.01.001 https://doi.org/10.1016/j.sdeng.2017.01....
, 2006 |
Individuals with DS |
127 |
2 to 24 |
Autism Behavior Checklist and Aberrant Behavior Checklist |
Parents |
DSM‐IV |
- |
2.33:1 |
Hepburn et al.66. Hepburn S, Philofsky A, Fidler DJ, Rogers S. Autism symptoms in toddlers with Down syndrome: a descriptive study. J Appl Res Intellect Disabil. 2008 Jan;21(1):48-57. https://doi.org/10.1111/j.1468-3148.2007.00368.x https://doi.org/10.1111/j.1468-3148.2007...
, 2007 |
Children with SD |
20 |
2 to 3 |
Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule-Generic |
Parents |
DSM-IV TR |
- |
2.45:1 |
Dressler et al.1818. Parlato-Oliveira E, Saint-Georges. Da clínica do bebê à avaliação do tratamento: uma microanálise transdisciplinar. In: Parlato-Oliveira E, Szejer M. O Bebê e os desafios da cultura. São Paulo (SP): Instituto Langage ; 2019 p. 69-79., 2011 |
Individuals with DS and/or autism living with their family |
24 |
6 to 34 |
Childhood Autism Rating Scale (CARS) |
Parents |
DSM-IV TR |
- |
0.84:1 |
Ji et al.2525. Starr EM, Berument SK, Tomlins M, Papanikolaou K, Rutter M. Brief report: autism in individuals with Down syndrome. J Autism Dev Disord. 2005 Oct;35(5):665-73. https://doi.org/10.1007/s10803-005-0010-0 https://doi.org/10.1007/s10803-005-0010-...
, 2011 |
Individuals with DS |
293 |
2 to 13 |
Autism Behavior Checklist |
Not informed |
DSM-IIIR and DSM-IV |
- |
3.16:1 |
Magyar et al.2828. Magyar CI, Pandolfi V, Dill CA. An initial evaluation of the Social Communication Questionnaire for the assessment of autism spectrum disorders in children with Down syndrome. J Dev Behav Pediatr. 2012 Feb;33(2):134-45. https://doi.org/10.1097/DBP.0b013e318240d3d9 https://doi.org/10.1097/DBP.0b013e318240...
, 2012 |
Individuals with DS |
71 |
4 to 14 |
Archival Social Communication Questionnaire (SCQ), Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule |
Not informed |
DSM-IV |
- |
1.29:1 |
Pandolfi et al.77. Pandolfi V, Caroline IM, Charles A. Screening for autism spectrum disorder in children with Down syndrome: An evaluation of the Pervasive Developmental Disorder in Mental Retardation Scale. J Intellect Dev Dis 2017;43(1):61-72., 2017 |
Individuals with DS |
71 |
3 to 15 |
Pervasive Developmental Disorder in Mental Retardation Scale (PDD- MRS), Social Communication Questionnaire - Lifetime Version (SCQ-L) and Autism Diagnostic Interview-Revised (ADI-R) |
Parents |
DSM-IV- TR |
- |
1.15:1 |
Godfrey et al.2828. Magyar CI, Pandolfi V, Dill CA. An initial evaluation of the Social Communication Questionnaire for the assessment of autism spectrum disorders in children with Down syndrome. J Dev Behav Pediatr. 2012 Feb;33(2):134-45. https://doi.org/10.1097/DBP.0b013e318240d3d9 https://doi.org/10.1097/DBP.0b013e318240...
, 2019 |
Individuals with DS born between January 1, 1996, and December 21, 2003, and who had a caregiver who spoke English or Spanish fluently |
33 |
born between 1996 and 2003 |
Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R) |
Parents |
DSM-V |
- |
2.01:00 |
Oxelgren et al.2929. Godfrey M, Hepburn S, Fidler DJ, Tapera T, Zhang F, Rosenberg CR, et al. Autism Spectrum Disorder (ASD) symptom profiles of children with comorbid Down Syndrome (DS) and ASD: a comparison with children with DS-only and ASD-only. Res Dev Disabil. 2019 Jun;89:83-93. https://doi.org/10.1016/j.ridd.2019.03.003 https://doi.org/10.1016/j.ridd.2019.03.0...
, 2019 |
Individuals with DS |
60 |
5 to 17 |
Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) |
Parents |
Not informed |
- |
1.8:1 |
Capone et al.2949. Gomes PTM, Lima LHL, Bueno MKG, Araújo LA, Souza NM. Autismo no Brasil, desafios familiares e estratégias de superação: revisão sistemática. J Pediatr (Rio J). 2015 Mar-Apr;91(2):111-21. https://doi.org/10.1016/j.jped.2014.08.009 https://doi.org/10.1016/j.jped.2014.08.0...
, 2005 |
Individuals with DS |
131 |
2 to 21 |
Behavior questionnaires, semi-structured neurological development assessment and observation during play or social interactions |
Parents |
DSM-IV |
12.9% |
2.7:1 |
DiGuiseppi et al.88. DiGuiseppi C, Hepburn S, Davis JM, Fidler DJ, Hartway S, Lee NR. Screening for autism spectrum disorders in children with Down syndrome: population prevalence and screening test characteristics. J Dev Behav Pediatr 2010;31:181–191., 2010 |
Individuals with DS born between January 1, 1996, and December 21, 2003, and who had a caregiver who spoke English or Spanish fluently |
123 |
2 to 21 |
Behavior questionnaires, semi-structured neurological development assessment and observation during play or social interactions |
Parents |
DSM-IV TR |
AUT 6.4% TEA 11.8% Total 18.2% |
1.86:1 |
Moss et al.3030. Oxelgren UW, Myrelid Å, Annerén G, Ekstam B, Göransson C, Holmbom A, et al. Prevalence of autism and attention-deficit-hyperactivity disorder in Down syndrome: a population-based study. Dev Med Child Neurol. 2017 Mar;59(3):276-83. https://doi.org/10.1111/dmcn.13217 https://doi.org/10.1111/dmcn.13217...
, 2013 |
Participants were included if there was information on the date of birth and diagnosis of DS from a professional (physician, clinical geneticist, pediatrician or other), if at least 75% of the SCQ (Rutter et al., 2003) had been completed and if the participant with SD was at least 4 years of age. |
108 |
4 to 62 |
Social Communication Questionnaire (SCQ) |
Parents |
Not informed |
19% |
0.7:1 |
Warner et al.3131. Capone GT, Grados MA, Kaufmann WE, Bernad-Ripoll S, Jewell A. Down syndrome and comorbid autism-spectrum disorder: characterization using the aberrant behavior checklist. Am J Med Genet A. 2005 May 1;134(4):373-80. https://doi.org/10.1002/ajmg.a.30622 https://doi.org/10.1002/ajmg.a.30622...
, 2014 |
Individuals with DS |
160 |
4 to 40 |
Lifetime version of the Social Communication Questionnaire (SCQ) and Strengths and Difficulties Questionnaire |
Parents |
Not informed |
AUT 16,5% TEA 37.7% |
1.2:1 |