Longer epilepsy duration and multiple lobe involvement predict worse seizure outcomes for patients with refractory temporal lobe epilepsy associated with neurocysticercosis

Longa duração de epilepsia e envolvimento de múltiplos lobos são fatores preditivos de pior controle das crises convulsivas em pacientes com epilepsia refratária do lobo temporal associada a neurocisticercose

ABSTRACT

Objective

To investigate the surgical outcomes of temporal lobe epilepsy associated with hippocampal sclerosis (TLE-HS) and neurocysticercosis (NCC).

Methods

A retrospective investigation of patients with TLE-HS was conducted in a tertiary center.

Results

Seventy-nine (62.2%), 37 (29.1%), 6 (4.7%), and 5 (3.9%) patients were Engel class I, II, III, and IV, respectively. Fifty-two (71.2%) patients with epilepsy durations ≤ 10 years prior to surgery were seizure-free 1 year after the operation compared to 27 (50.0%) patients with epilepsy durations > 10 years (p = 0.0121). Forty-three (72.9%) patients with three or fewer lobes affected by NCC were seizure-free one year after the operation, and 36 (52.9%) patients with more than three involved lobes were seizure-free after surgery (p = 0.0163).

Conclusions

Longer epilepsy durations and multiple lobe involvement predicted worse seizure outcomes in TLE-HS plus NCC patients.

temporal lobe epilepsy; hippocampal sclerosis; neurocysticercosis