Triglyceride-glucose index as a predictor of obstructive sleep apnoea severity in the absence of traditional risk factors

Sökücü, Sinem Nedime; Aydın, Şenay; Satıcı, Celal; Önür, Seda Tural; Özdemir, Cengiz

doi:10.1055/s-0043-1776411

Acessibilidade / Reportar erro

Brasil

Arquivos de Neuro-Psiquiatria

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Original Article • Arq. Neuro-Psiquiatr. 81 (10) • 2023 • https://doi.org/10.1055/s-0043-1776411 copy

Triglyceride-glucose index as a predictor of obstructive sleep apnoea severity in the absence of traditional risk factors

Índice de triglicerídeos-glicose como preditor de gravidade da apneia obstrutiva do sono na ausência de fatores de risco tradicionais

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective

We evaluated the association between the triglyceride–glucose (TG) index, a marker of insulin resistance, and obstructive sleep apnoea (OSA) severity in patients without diabetes mellitus, obesity, and metabolic syndrome.

Methods

This retrospective cohort study included 1,527 patients. We used univariate and multivariate analyses to identify the independent predictors associated with OSA.

Results

Most patients were males (81.5%) with a mean age of 43.9 ± 11.1 (15–90) years. Based on the apnoea–hypopnea index (AHI), 353 (23.1%) patients were included in the control group, whereas 32.4%, 23.5%, and 21% had mild, moderate, and severe OSA, respectively. The TG index values demonstrated significant associations with OSA patients compared with the control group (p = 0.001). In addition, the mean values of the oxygen desaturation index (ODI), AHI, minimum oxygen saturation, and total sleep time percentage with saturation below 90% demonstrated statistically significant differences among the TG index groups (p: 0.001; p:0.001; p:0.001; p:0.003). The optimal TG index cutoff value to predict OSA was 8.615 (AUC = 0.638, 95% CI = 0.606–0.671, p = 0.001). In multivariate logistic regression analysis, after adjusting for age, sex, and body mass index, the TG index was independently associated with OSA patients.

Conclusion

The TG index is independently associated with increased risk for OSA. This indicates that this index, a marker for disease severity, can be used to identify severe OSA patients on waiting lists for PSG.

Keywords
Sleep Apnea, Obstructive; Prognosis; Triglyceride Glucose Index

		No OSA (n = 353)	Mild OSA (n = 494)	Moderate OSA (n = 359)	Severe OSA (n = 321)	P
Age		39.51 ± 11.39	44.25 ± 10.38	46.28 ± 10.46	45.97 ± 11.19	0.001^* * p < 0.05.
Gender (male %)		224 (63.5%)	399 (80.8%)	324(90.3%)	298 (92.8)	0.001^* * p < 0.05.
BMI (kg/m²)		25.36 ± 2.86	26.53 ± 2.22	26.94 ± 1.91	27.34 ± 2.02	0.001^* * p < 0.05.
Waist Circumference (cm)		87.72 ± 9.68	92.92 ± 7.91	94.92 ± 6.95	96.34 ± 7.36	0.001^* * p < 0.05.
Hip Circumference (cm)		97.52 ± 7.64	100.01 ± 6.44	99.74 ± 7.38	100.63 ± 5.38	0.001^* * p < 0.05.
Neck Circumference (cm)		35.27 ± 3.41	36.75 ± 3.19	37.67 ± 2.88	38.13 ± 3.09	0.001^* * p < 0.05.
WHR		0.903 ± 0.123	0.930 ± 0.067	0.964 ± 0.272	0.958 ± 0.064	0.001^* * p < 0.05.
NHR		0.208 ± 0.017	0.214 ± 0.018	0.218 ± 0.016	0.220 ± 0.018	0.001^* * p < 0.05.
Smoking status, n (%)	Active smoker	155 (44.2%)	188 (38.1%)	139(38.7%)	142 (44.2%)	0.007^* * p < 0.05.
	Never smoker	152 (43.3%)	193 (39.1%)	133 (37.0%)	104 (32.4%)
	Ex smoker	44 (12.5%)	113 (22.9%)	87(24.2%)	75 (73.4%)
Cigarette pocket/year		15.50 ± 10.33	16.99 ± 9.99	18.02 ± 12.70	18.14 ± 10.55	0.051
Hypertension (%)		23 (6.5%)	33 (6.7%)	36 (10.0%)	41 (12.8%)	0.007^* * p < 0.05.
IHD (%)		2 (0.6%)	14 (2.8%)	14 (3.9%)	12 (3.7%)	0.026^* * p < 0.05.
CHF(%)		8 (2.3%)	20 (4.0%)	20 (5.6%)	11 (3.4%)	0.142
Total cholesterol (mg/dL)		198.14 ± 42.32	210.70 ± 41.03	213.61 ± 42.85	214.77 ± 41.01	0.001^* * p < 0.05.
HDL cholesterol level (mg/dL)		49.50 ± 12.06	47.56 ± 11.21	45.56 ± 10.02	44.26 ± 9.37	0.001^* * p < 0.05.
LDL cholesterol level (mg/dL)		124.31 ± 35.89	134.15 ± 35.66	156.54 ± 37.15	136.93 ± 35.26	0.001^* * p < 0.05.
Triglyceride level (mg/dL)		122.79 ± 72.10	145.35 ± 96.20	159.25 ± 107.39	167.18 ± 99.39	0.001^* * p < 0.05.
Glucose level (mmol/L)		92.92 ± 9.14	95.16 ± 8.88	95.68 ± 9.15	97.30 ± 8.88	0.001^* * p < 0.05.
TyG		8.51 ± 0.49	8.69 ± 0.53	8.78 ± 0.52	8.86 ± 0.51	0.001^* * p < 0.05.
CRP (mg/dL)		2.80 ± 4.89	3.05 ± 4.92	3.21 ± 3.76	4.75 ± 8.02	0.001^* * p < 0.05.
ESS		8.24 ± 4.17	8.71 ± 4.54	8.45 ± 4.28	9.64 ± 4.85	0.001^* * p < 0.05.
Total sleep time (min)		402.87 ± 40.52	407.98 ± 38.27	403.49 ± 42.27	386.89 ± 62.73	0.001^* * p < 0.05.
Sleep (%)		86.95 ± 7.16	87.77 ± 7.21	87.31 ± 7.25	87.16 ± 7.22	0.397
REM (%)		19.66 ± 5.60	20.27 ± 5.40	19.27 ± 5.87	17.08 ± 6.34	0.001^* * p < 0.05.
AHI (1/h)		2.30 ± 1.46	9.09 ± 2.70	20.99 ± 4.04	48.31 ± 15.34	0.001^* * p < 0.05.
ODI (1/h)		2.26 ± 5.34	6.92 ± 4.39	16.87 ± 6.02	41.44 ± 16.67	0.001^* * p < 0.05.
TST 90% (min)		3.25 ± 23.85	6.90 ± 28.82	11.14 ± 24.95	45.45 ± 56.21	0.001^* * p < 0.05.
Min Sat02 (%)		91.06 ± 3.14	87.59 ± 4.40	84.85 ± 5.52	78.72 ± 8.39	0.001^* * p < 0.05.

Academia Brasileira de Neurologia - ABNEURO R. Vergueiro, 1353 sl.1404 - Ed. Top Towers Offices Torre Norte, 04101-000 São Paulo SP Brazil, Tel.: +55 11 5084-9463 | +55 11 5083-3876 - São Paulo - SP - Brazil
E-mail: revista.arquivos@abneuro.org

Acompanhe os números deste periódico no seu leitor de RSS

[1] Address for correspondence Şenay Aydın (email: aydin.senay@hotmail.com)