Septo-optic dysplasia with late-onset seizure: MRI and ophthalmological featuresA 31-year-old man presented with tonic-clonic seizures, started at 15-year-old, that improved with carbamazepine. Fundoscopy disclosed small optic discs and arterial tortuosity. Neurological examination and visual acuity were normal. Brain MRI showed hypoplasia of the optic nerves, absence of septum pellucidum and polymicrogyria (Figure 1). Optical coherence tomography showed bilateral retinal nerve fiber layer thinning (Figure 2). Septo-optic dysplasia was diagnosed.
(A) Axial T2-weighted image shows absence of septum pellucidum. (B) Axial FLAIR sequence demonstrates hypoplasia of the optic nerves, more marked on the right (arrows). (C) Coronal T1-weighted image shows absence of septum pellucidum and polymicrogyria in posterior sylvian fissures (arrows).
A: Retinography shows hypoplastic optic disc in OD and small disc in OS, arterial tortuosity (asterisks) and reduced visibility of the retinal nerve fibers (arrows) bilaterally. B and C: Absent cup in OD and bilateral temporal pallor. D and E: Thickness maps and graphs show retinal nerve fiber layer thinning in both eyes.
Septo-optic dysplasia is usually reported in children, and is characterized by optic nerve hypoplasia, absent septum pellucidum, cortical malformations and pituitary dysfunction1. This patient had no endocrinopathy, and presented with late onset epilepsy, which is unusual in septo-optic dysplasia1,2. The typical MRI changes and optic abnormalities were the clues for the diagnosis2.
References
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1 Miller SP, Shevell MI, Patenaude Y, Poulin C, O’Gorman AM. Septo-optic dysplasia plus: a spectrum of malformations of cortical development. Neurology. 2000;54(8):1701-3. https://doi.org/10.1212/WNL.54.8.1701
» https://doi.org/10.1212/WNL.54.8.1701 -
2 AlKhateeb M, McLachlan R, Burneo J, Diosy D, Mirsattari S. Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course. Epilepsy Behav Case Rep. 2017;8:73-84. https://doi.org/10.1016/j.ebcr.2017.04.001
» https://doi.org/10.1016/j.ebcr.2017.04.001
Publication Dates
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Publication in this collection
13 May 2019 -
Date of issue
Apr 2019
History
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Received
14 Nov 2018 -
Accepted
26 Dec 2018
