Arq Neuropsiquiatr. 2019;77(7):509-520
Consensus of the Brazilian Headache Society on the treatment of chronic migraine
DOI: http://dx.doi.org/10.1590/0004-282x20190078
The table 5:
Table 5 Oral drugs evaluated in the treatment of chronic migraine in adults: evidence of efficacy, class of recommendation, recommended doses and risk categories regarding use during pregnancy and lactation.
Drug | Evidence | Recommendation | Dose (mg/day) | Risk during pregnancy* | Risk during lactation** † | References |
---|---|---|---|---|---|---|
Neuromodulators | ||||||
Topiramate | I | A | 50-200 | D | L3 | 62, 64-66, 70 |
Valproate | II | B | 500-2000 | X | L2 | 71 |
Gabapentin | II | B | 900-1800 | C | L2 | 72 |
Pregabalin | III | C | 125-450 | C | L2 | 73 |
Zonisamide | III | C | 50-200 | D | L5 | 74 |
Beta-blockers | ||||||
Atenolol | III | C | 50-200 | C | L3 | 75 |
Tricyclics | ||||||
Amitriptyline | II | C | 50-100 | C | L2 | 76 |
Calcium channel blockers | ||||||
Flunarizine | III | C | 10 | C | L5 | 77 |
Miscellaneous | ||||||
Tizanidine | II | B | fev/24 | C | L3 | 78 |
Should be:
Table 5 Oral drugs evaluated in the treatment of chronic migraine in adults: evidence of efficacy, class of recommendation, recommended doses and risk categories regarding use during pregnancy and lactation.
Drug | Evidence | Recommendation | Dose (mg/day) | Risk during pregnancy* | Risk during lactation** † | References |
---|---|---|---|---|---|---|
Neuromodulators | ||||||
Topiramate | I | A | 50-200 | D | L3 | 62, 64-66, 70 |
Valproate | II | B | 500-2000 | X | L2 | 71 |
Gabapentin | II | B | 900-1800 | C | L2 | 72 |
Pregabalin | III | C | 125-450 | C | L2 | 73 |
Zonisamide | III | C | 50-200 | D | L5 | 74 |
Beta-blockers | ||||||
Atenolol | III | C | 50-200 | C | L3 | 75 |
Tricyclics | ||||||
Amitriptyline | II | C | 50-100 | C | L2 | 76 |
Calcium channel blockers | ||||||
Flunarizine | III | C | 10 | C | L5 | 77 |
Miscellaneous | ||||||
Tizanidine | II | B | 2-24 | C | L3 | 78 |
Publication Dates
-
Publication in this collection
24 Oct 2019 -
Date of issue
Oct 2019