Neurological complications in 33 patients following antirabies vaccination (modified Fermi vaccine) were studied. For analysing purposes of the therapeutic effects the patients were divided in three groups: the first group with symptomatic treatment only (9 patients); the second with symptomatic treatment plus intravenous or intramuscular ACTH or corticosteroids (15 patients); the third with symptomatic treatment plus intrathecal methylprednisolone acetate (9 patients). In the first group one of the patients remained with a neurological sequel. In the second group one patient also had a neurological sequel, two died, six improved and six had complete recovery. In the third group a patient died from a respirator accident, one improved and seven had complete recovery. The authors had the clinical impression that the results were considerably better in the third group of cases.