Resveratrol and sirtinol |
SK-N-BE neuroblastoma cells |
Added in medium (0, 2.5, 5, 7.5, 10 and 15 µM) |
Protected cells from oxidative stress induced by H2O2 and 6-OHDA, increasing cell viability. Sirtinol inhibited SIRT1 |
Albani et al.4747. Albani D, Polito L, Batelli S, De Mauro S, Fracasso C, Martelli G, et al. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide. J Neurochem. 2009 Sep;110(5):1445-56. https://doi.org/10.1111/j.1471-4159.2009.06228.x https://doi.org/https://doi.org/10.1111/...
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Resveratrol |
Sprague-Dawley rats |
Intraperitoneal injection (10, 20 and 40 mg/kg/day) |
Improved cognitive impairment and attenuated LPS-induced neuroinflammation in rats by inhibiting the generation of TNF, APP, COX-2 and NF-kB phosphorylation in the hippocampus |
Gong et al.4141. Gong Q, Li F, Jin F, Chan N. Resveratrol Attenuates Neuroinflammation-mediated Cognitive Deficits in Rats. J Health Sci. 2010;56(6):655-63. https://doi.org/https://doi.org/10.1248/jhs.56.655 https://doi.org/https://doi.org/https://...
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Resveratrol |
Mouse neuroblastoma (N2a) cells |
Added in medium (5 µM) |
Prevented the abnormal expression of peroxiredoxins and mitochondrial structural genes and preserved mitochondrial function, protecting cells against Aβ toxicity |
Manczak et al.4242. Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, et al. Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer’s disease neurons. J Alzheimer Dis. 2010 Jun;20(s2):S609-31. https://doi.org/10.3233/JAD-2010-100564 https://doi.org/https://doi.org/10.3233/...
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Resveratrol |
Sprague-Dawley rats |
Injection of 100 μm/5 μL in the lateral ventricle for seven days |
Reversed expression of iNOS, reduced amyloid accumulation, prevented neuronal death, increased HO-1 expression, suppressed lipid peroxidation in hippocampus, and improved spatial memory |
Huang et al.3939. Huang TC, Lu KT, Wo YYP, Wu YJ, Yang YL. Resveratrol Protects Rats from Aβ-induced Neurotoxicity by the Reduction of iNOS Expression and Lipid Peroxidation. Musaro A, organizador. PLoS One 2011;6(12):e29102. https://doi.org/10.1371/journal.pone.0029102 https://doi.org/https://doi.org/10.1371/...
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Resveratrol |
BV-2 microglial cells and RAW 264.7 macrophages and APP/PS1 mice |
Added in medium and supplementation of 350 mg/kg/day for 15 weeks |
Inhibited activation of NF-κB and its target genes (TNF and IL-6) and prevented activation of Aβ-mediated microglia |
Capiralla et al.3838. Capiralla H, Vingtdeux V, Zhao H, Sankowski R, Al-Abed Y, Davies P, et al. Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade. J Neurochem. 2012 Feb;120(3):461-72. https://doi.org/10.1111/j.1471-4159.2011.07594.x https://doi.org/https://doi.org/10.1111/...
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Resveratrol |
PC12 cells |
Added in medium (12.5, 25, 50 and 100 μM) |
Increased cell viability, reduced apoptosis, attenuated Aβ-induced neurotoxicity and regenerated SIRT1 activity |
Feng et al.22. Feng X, Liang N, Zhu D, Gao Q, Peng L, Dong H, et al. Resveratrol Inhibits β-Amyloid-Induced Neuronal Apoptosis through Regulation of SIRT1-ROCK1 Signaling Pathway. PLoS One. 2013 Mar;8(3):e59888. https://doi.org/10.1371/journal.pone.0059888 https://doi.org/https://doi.org/10.1371/...
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Resveratrol and AGK-2 |
Sprague-Dawley’s astroglia cell culture |
Added in medium (2, 10 and 50 μM) |
Resveratrol and AGK-2 reduced astrocyte activation and pro-inflammatory mediator production |
Scuderi et al.4949. Scuderi C, Stecca C, Bronzuoli MR, Rotili D, Valente S, Mai A, et al. Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer's disease. Front Pharmacol. 2014 May;13(5)89. https://doi.org/10.3389/fphar.2014.00089 https://doi.org/https://doi.org/10.3389/...
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Resveratrol and LD55 |
AβPP/PS1 mice |
Supplementation of 100 ppm for 12 months |
Resveratrol reduced microglia activation, mainly in the hippocampus. LD55 had the same efficacy, even without the hydroxyl group |
Solberg et al.2020. Solberg NO, Chamberlin R, Vigil JR, Deck LM, Heidrich JE, Brown DC, et al. Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer’s Disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain. J Alzheimers Dis. 2014 Mar;40(1):191-212. https://doi.org/10.3233/JAD-131031 https://doi.org/https://doi.org/10.3233/...
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Resveratrol |
SH-SY5Y neuroblastoma cells |
Added in medium (10 and 20 µM) |
Reduced ROS production stimulated by AGEs |
Ko et al.4444. Ko SY, Ko HA, Chu KH, Shieh TM, Chi TC, Chen HI, et al. The possible mechanism of advanced glycation end products (AGEs) for Alzheimer’s disease. PLoS One. 2015 Nov;10(11):e0143345. https://doi.org/10.1371/journal.pone.0143345 https://doi.org/https://doi.org/10.1371/...
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Trans-resveratrol |
Rat H19-7 neuronal cell line |
Added in medium (10 μM) |
Attenuated lipid peroxidation, regulated levels of antioxidant enzymes and increased non-enzymatic antioxidants levels |
Rege et al.1515. Rege S, Geetha T, Broderick T, Babu J. Resveratrol protects β amyloid-induced oxidative damage and memory associated proteins in H19-7 hippocampal neuronal cells. Curr Alzheimer Res. 2015;12(2):147-56. https://doi.org/10.2174/1567205012666150204130009 https://doi.org/https://doi.org/10.2174/...
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Resveratrol |
BV-2 microglial cells |
Added in medium (1, 3, 10 or 30 μM) |
Reduced ROS production and inhibited NO, TNF and IL-1β production |
Yao et al.88. Yao Y, Li J, Niu Y, Yu JQ, Yan L, Miao ZH, et al. Resveratrol inhibits oligomeric Aβ-induced microglial activation via NADPH oxidase. Mol Med Rep. 2015 Aug;12(4):6133-9. https://doi.org/10.3892/mmr.2015.4199 https://doi.org/https://doi.org/10.3892/...
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Resveratrol |
Wistar female rats |
20, 40 and 80 mg/kg/day for 12 weeks |
Reduced expression of AGEs and MMP-9, preserving BBB integrity |
Zhao et al.4545. Zhao HF, Li N, Wang Q, Cheng XJ, Li XM, Liu TT. Resveratrol decreases the insoluble Aβ1-42 level in hippocampus and protects the integrity of the blood-brain barrier in AD rats. Neuroscience. 2015 Dec;310:641-9. https://doi.org/10.1016/j.neuroscience.2015.10.006 https://doi.org/https://doi.org/10.1016/...
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Resveratrol |
HEK-AbPP cells |
Added in medium (0.5 μM) |
Ceased most of the neurotoxicity and pro-apoptotic effects on cells treated with γ-secretase inhibitor (LY450139) |
Colin et al.4040. Colin J, Allouche A, Chauveau F, Corbier C, Pauron-Gregory L, Lanhers M-C, et al. Improved neuroprotection provided by drug combination in neurons exposed to cell-derived soluble amyloid-β peptide. J Alzheimers Dis. 2016 May;52(3):975-87. https://doi.org/10.3233/JAD-151110 https://doi.org/https://doi.org/10.3233/...
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Resveratrol |
Human neural stem cells (HhNSCs) |
Added in medium (10 µM) |
Inhibited increase of TNF and IL-1β expression, preventing reduction on cell viability, prevented NF-κB increase, and normalized oxidative stress |
Chiang et al.33. Chiang MC, Nicol CJ, Cheng YC. Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-β-induced inflammation and oxidative stress. Neurochem Int. 2018 May;115:1-10. https://doi.org/10.1016/j.neuint.2017.10.002 https://doi.org/https://doi.org/10.1016/...
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Resveratrol |
Neuro-2a (N2a) cell culture |
Added in medium (0, 2.5, 5, 10, 25 and 50 μM) |
Decreased cytotoxicity and cellular apoptosis and inhibited tau hyperphosphorylation |
He et al.2424. He X, Li Z, Rizak JD, Wu S, Wang Z, He R, et al. Resveratrol attenuates formaldehyde induced hyperphosphorylation of tau protein and cytotoxicity in N2a cells. Front Neurosci. 2017 Jan;31(10):598. https://doi.org/10.3389/fnins.2016.00598 https://doi.org/https://doi.org/10.3389/...
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Resveratrol |
PC12 cell culture |
Added in medium (0, 10, 20 and 40 μM) |
Increased cell viability and stimulated HO-1 production |
Hui et al.4343. Hui Y, Chengyong T, Cheng L, Haixia H, Yuanda Z, Weihua Y. Resveratrol attenuates the cytotoxicity induced by amyloid-β1-42 in PC12 cells by upregulating heme oxygenase-1 via the PI3K/Akt/Nrf2 pathway. Neurochem Res. 2018 Oct;43(2):297-305. https://doi.org/10.1007/s11064-017-2421-7 https://doi.org/https://doi.org/10.1007/...
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Resveratrol |
CSF samples of AD humans |
Prior treatment with an initial dose of 500 mg/day, increasing every 13 weeks until completion with 1,000 mg twice/day |
Attenuated neuroinflammation, reduced proinflammatory markers and MMP-9 in the CSF, attenuated the cognitive and functional decline of individuals |
Moussa et al.4646. Moussa C, Hebron M, Huang X, Ahn J, Rissman RA, Aisen PS, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. J Neuroinflammation. 2017 Jan;14(1):1. https://doi.org/10.1186/s12974-016-0779-0 https://doi.org/https://doi.org/10.1186/...
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Resveratrol |
Rat astrocytes (RA) and microglia N9 cell lines |
Added in medium (5, 12.5, and 25 μM in RA cell line and 10, 20, and 40 μM in N9 cell line) |
Inhibited the release of inflammatory cytokines by inhibiting NF-κB signaling |
Haifeng et al.3737. Haifeng Z, Qian W, Xuejiao C, Xuemin L, Na L. Inhibitive effect of resveratrol on the inflammation in cultured astrocytes and microglia induced by Aβ1-42. Neuroscience 2018 May;379:390-404. https://doi.org/10.1016/j.neuroscience.2018.03.047 https://doi.org/https://doi.org/10.1016/...
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Trans-resveratrol, piceatannol and trans-4-hidroxistilbene |
Culture of primary neurons in the cortex of Sprague-Dawley rats |
Added in medium (20 and 50 μM) |
The stilbenoids inhibited Aβ-induced neurotoxicity, resulting in ROS decrease |
Wen et al.1717. Wen H, Fu Z, Wei Y, Zhang X, Ma L, Gu L, et al. Antioxidant Activity and Neuroprotective Activity of Stilbenoids in Rat Primary Cortex Neurons via the PI3K/Akt Signalling Pathway. Molecules. 2018 Sep;23(9):2328. https://doi.org/10.3390/molecules23092328 https://doi.org/https://doi.org/10.3390/...
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