The specific treatment of tetanus with antitoxin fails in almost fifty percent of the cases, in accordance with the different statistical works made in many countries. The authors point out to the main reason of such failure, the tetanic toxin property of attaching to the nervous system in an irreversible way, so that the antitoxin is unable to break up the complex system formed by tetanic toxin-nerve cell. For that reason, it is useless to give large amounts of antitoxin, besides it has been stated by many workers that 100.000 U.A. are sufficient to produce useful titers against any case of tetanus during the average duration of the illness (20 to 25 days). The authors have then tried to modify the non-specific treatment or better the so-called symptomatic treatment. The importance of sedative measure is emphasized, based on experiments of many workers and their own. They mention specially the depressive action on the respiratory center by drugs used routinely, which have been demonstrated by Firor as contributing factors to the mechanism of death in tetanus. They have had the oportunity to use a new drug with a muscle relaxing central action (Tolserol), which does not produce either a depression or a paralysis of the respiration, but shows an efficient muscular relaxing action, decreasing or even abolishing the spasmus occurring in the course of the disease. They finally present a table with results of 40 patients treated with this new drug (7.5% of net mortality) in comparison with former ones in the same hospital (32.5% of net mortality).