The case of a male patient having had episodes of confusion and motor deficits at age 5, 9 and 11, admited to the hospital on these three occasions is reported. All investigations showed negative results, except for the EEG. A clue for the clinical diagnosis of confusional state due to migraine was the past history of the patient, who suffered several migranous attacks from the age of 9. A review of the pathophysiology is made, based on the available literature.