Parkinsonismo induzido pela flunarizina

Sá, Paulo N. Discher de; Heinisch, Liana Miriam Miranda

doi:10.1590/S0004-282X1989000400015

Resumos

Os autores estudaram 19 pacientes com parkinsonismo induzido pela flunarizina. A retirada da medicação levou ao desaparecimento dos sinais e sintomas em todos os casos em período de tempo que variou de 7 dias a 10 meses. Depressão foi observada em 68,5% da amostra.

The authors studied 19 patients with parkinsonism induced by flunarizine. All them improved when the drug therapy was discontinued for periods from 7 days to 10 months. Depression was observed in 68.5% of the patients.

Parkinsonismo induzido pela flunarizina

Parkinsonism induced by flunarizine

Paulo N. Discher de Sá^I; Liana Miriam Miranda Heinisch^II

^IServiço de Neurologia do Hospital Governador Celso Ramos (HGCR), Florianópolis: Professor Adjunto da Disciplina de Neurologia do Departamento de Clínica Médica da Universidade Federal de Santa Catarina

^IIServiço de Neurologia do Hospital Governador Celso Ramos (HGCR), Florianópolis:Médica Residente de Neurologia

RESUMO

Os autores estudaram 19 pacientes com parkinsonismo induzido pela flunarizina. A retirada da medicação levou ao desaparecimento dos sinais e sintomas em todos os casos em período de tempo que variou de 7 dias a 10 meses. Depressão foi observada em 68,5% da amostra.

SUMMARY

The authors studied 19 patients with parkinsonism induced by flunarizine. All them improved when the drug therapy was discontinued for periods from 7 days to 10 months. Depression was observed in 68.5% of the patients.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Serviço de Neurologia, Hospital Governador Celso Ramas - Rua Irmã Benwarda s/n - 88015 Florianópolis SC - Brasil.

Referências bibliográficas

1. Bamrah JS, Soni SD - Drug-induced Parkinson's disease. Lancet 2: 1031, 1987.
2. Borges M, Ghoos E, Thoné F, Van Nueten JM - Effects of flunarizine on the distribution of calcium in vascular smooth muscle. Blood Vessels 17: 123, 1980.
3. Calne DB, Langston JW - Aetiology of Parkinson's disease. Lancet 2:1457, 1983.
4. Chouza C, Caamaño JC, Aljanati R, Scaramelli A, DeMedina O, Romero S - Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine. Lancet 1: 1303, 1986.
5. Holmes B, Brogden RN, Heel RC, Speight TM, Avery GS - Flunarizine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drug 27: 6, 1984.
6. Indo T, Ando K - Metoclopramide-induced parkinsonism. Arch Neurol 39: 494, 1982.
7. Koller WC - Alcohol and Parkinson disease. Ann Neurol 13: 466, 1983.
8. Micheli F, Pardal MF, Gatto M, Torres M, Paradiso MD, Pasesa IC, Giannaula MD - Flunarizine and cinnarizine-induced extrapyramidal reaction. Neurology 37: 881, 1987.
9. Sandyk R - Parkinsonism induced by diazepan. Biol Psychiat 21: 1229, 1986.
10. Stephen PJ, Williamson J - Drug-induced Parkinsonism in the elderly. Lancet 1: 1082, 1984.
11. Wilson JA, Primrose WR - Drug-induced parkinsonism. Br Med J 293: 957, 1986.
12. Wilson JA, Primrose WR, Smith RG - Prognosis of drug-induced parkinsonism disease. Lancet 1: 443, 1987.

Datas de Publicação

Publicação nesta coleção
01 Jun 2011
Data do Fascículo
Dez 1989

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Bamrah JS, Soni SD - Drug-induced Parkinson's disease. Lancet 2: 1031, 1987.

[2] 2. Borges M, Ghoos E, Thoné F, Van Nueten JM - Effects of flunarizine on the distribution of calcium in vascular smooth muscle. Blood Vessels 17: 123, 1980.

[3] 3. Calne DB, Langston JW - Aetiology of Parkinson's disease. Lancet 2:1457, 1983.

[4] 4. Chouza C, Caamaño JC, Aljanati R, Scaramelli A, DeMedina O, Romero S - Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine. Lancet 1: 1303, 1986.

[5] 5. Holmes B, Brogden RN, Heel RC, Speight TM, Avery GS - Flunarizine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drug 27: 6, 1984.

[6] 6. Indo T, Ando K - Metoclopramide-induced parkinsonism. Arch Neurol 39: 494, 1982.

[7] 7. Koller WC - Alcohol and Parkinson disease. Ann Neurol 13: 466, 1983.

[8] 8. Micheli F, Pardal MF, Gatto M, Torres M, Paradiso MD, Pasesa IC, Giannaula MD - Flunarizine and cinnarizine-induced extrapyramidal reaction. Neurology 37: 881, 1987.

[9] 9. Sandyk R - Parkinsonism induced by diazepan. Biol Psychiat 21: 1229, 1986.

[10] 10. Stephen PJ, Williamson J - Drug-induced Parkinsonism in the elderly. Lancet 1: 1082, 1984.

[11] 11. Wilson JA, Primrose WR - Drug-induced parkinsonism. Br Med J 293: 957, 1986.

[12] 12. Wilson JA, Primrose WR, Smith RG - Prognosis of drug-induced parkinsonism disease. Lancet 1: 443, 1987.