Malignant melanoma of the cerebello-pontine angle region

Braga, F. Menezes; Tella Jr, Oswaldo I.; Jordy, Adelmo Ferreira Ceme F.

doi:10.1590/S0004-282X1989000400020

Abstracts

A case of malignant melanoma in the cerebello-pontine angle region is presented in a 72 years old female patient, who had neurological examination and CT scan suggestive of acoustic neuroma. The surgical finding and the histological examination provided the diagnosis. As a primary focus was not found on clinical examination and although autopsy was not carried out, there is a possibility of the diagnosis being a primary malignant melanoma in CNS. This specific location for this kind of tumor was found to be rare when literature is looked up.

Registro de caso de melanoma maligno na região do ângulo ponto-cerebelar em paciente do sexo feminino, com 72 anos de idade, com exame neurológico e tomografia computadorizada sugestivos de neurinoma do acústico, em que o diagnóstico foi estabelecido pelo achado cirúrgico e pelo exame histopatológico. Como não foi achado foco primário no exame clínico e embora não tenha sido feita autopsia, há possibilidade de que o diagnóstico seja de melanoma maligno primário no sistema nervoso central. Esta localização particular desse tipo de tumor é considerada rara, levando em conta os dados da literatura.

Malignant melanoma of the cerebello-pontine angle region

Melanoma maligno da região do ângulo ponto-cerebelar

F. Menezes Braga; Oswaldo I. Tella Jr.; Adelmo Ferreira Ceme F. Jordy

Neurosurgical Department, Escola Paulista de Medicina, São Paulo

SUMMARY

A case of malignant melanoma in the cerebello-pontine angle region is presented in a 72 years old female patient, who had neurological examination and CT scan suggestive of acoustic neuroma. The surgical finding and the histological examination provided the diagnosis. As a primary focus was not found on clinical examination and although autopsy was not carried out, there is a possibility of the diagnosis being a primary malignant melanoma in CNS. This specific location for this kind of tumor was found to be rare when literature is looked up.

RESUMO

Registro de caso de melanoma maligno na região do ângulo ponto-cerebelar em paciente do sexo feminino, com 72 anos de idade, com exame neurológico e tomografia computadorizada sugestivos de neurinoma do acústico, em que o diagnóstico foi estabelecido pelo achado cirúrgico e pelo exame histopatológico. Como não foi achado foco primário no exame clínico e embora não tenha sido feita autopsia, há possibilidade de que o diagnóstico seja de melanoma maligno primário no sistema nervoso central. Esta localização particular desse tipo de tumor é considerada rara, levando em conta os dados da literatura.

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6. Bachtiarow WA, apud Gibson JB et al. 21.

Dr. F. Menezes Braga - Rua Cardoso de Mello Jr. 595 - 05462 São Paulo SP - Brasil.

1. Albertengo JB - Melanoblastoma primitivo de fosa posterior. Anales de Cirurgia 16: 224, 1951.
2. Amer MH, Sarraf MA, Baker L.H, Vaitkvicius VK - Malignant melanoma and central nervous system metastases. Cancer 42: 660, 1978.
3. Antunes ACM, Coutinho MF, Coutinho LBM - Hemorragias em metástases intracranianas de melanoma. Arq Neuro-Psiquiat (São Paulo) 37: 180, 1979.
4. Arlant PA, Gruwnet ML, Heilbrun MP - Primary malignant melanoma of the pineal region. Surg Neurol 7: 121, 1977.
5. Arnvig J, Christensen E - Primary benignant intracranial melanoma. Acta Chir Scand 82: 217, 1939.
7. Bacchi AK, Sarkar SK, Chakraborti DP, Roy CK - Melanotic spinal schwannoma. Surg Neurol 3: 79, 1975.
8. Bailley P - Intracranial Tumors. Ed 2. Thomas, Springfield, 1948, pg 152.
9. Beatty TA - Malignant melanoma of the choroid plexus epithelium. J Neurosurg 36: 344, 1972.
10. Bergdahl L, Boquist L, Liliequist B, Thulin C, Tovi D - Primary malignant melanoma of the central nervous system. Acta Neurochir 26: 139, 1972.
11. Best PV - A medulloblastoma-like tumour with melanin formation. J Path 110: 109, 1973.
12. Bjorkesten GA - Primary melanoma of the leptomeninges. Acta Psychiat 24: 307, 1949.
13. Bullard DE, Cox EB, Seigler HF - Central nervous system metastases in malignant melanoma. Neurosurgery 8: 26, 1981.
14. Chang P, Hnapper WH - Metastatic melanoma of unknown primary. Cancer 49: 1106, 1982.
15. Das Gupta T, Brasfield R - Metastatic melanoma: a clinicopathological study. Cancer 17: 1323, 1964.
16. Dastur DK, Sinh G, Pandya SK - Melanotic tumor of the acoustic nerve. J Neurosurg 27: 166, 1967.
17. Enriquez R, Egbert B, Bullock J - Primary malignant melanoma of central nervous system. Arch Pathol 95: 392, 1973.
18. Fernandez E, Maira G, Puca A, Vignati A - Multiple intracranial metastases of malignant melanoma with long-term survival. J Neurosurg 60: 621, 1984.
19. Fischer S - Primary perivascular cerebral, cerebellar and leptomeningeal melanoma. Acta Psychiat Scand 31: 21, 1956.
20. Fowler M, Simpson DA - A malignant melanin-forming tumour of the cerebellum. J Path Bact 84: 307, 1962.
21. Gibson JB, Burrows D, Weir WP - Primary melanoma of the meninges. J Path Bact 74: 419, 1957.
22. Hayward RD - Malignant melanoma and the central nervous system. J Neurol Neurosurg Psychiat 39: 526, 1976.
23. Hodspn JJ - An intra-osseous tumour combination of biological importance-invasion of a melanotic schwannoma by a adamantinonma. J Path Bact 82: 257, 1961.
24. Humes RA, Roskamp J, Eisenbrey AB - Melanosis and hydrocephalus. J Neurosurg 61: 365, 1984.
25. Lamas E, Lobato RD, Sotelo T, Ricoy JR, Castro S - Neurocutaneous melanosis.. Acta Neurochir 36: 93, 1977.
26. Lesoin F, Leys D, Verier A, Krivosic I, Vaneecloo FM, Jomin M - Le tumeurs mélaniques primitives du system nerveux central. Rev Oto-Neuro-Ophtalm 55: 443, 1983.
27. Limas C, Tio FO - Meningeal melanocytoma (Melanotic meningioma). Cancer 30: 1286, 1972.
28. Madajewicz S, Karakousis C, West CR, Caracandas J, Avellanosa AM - Malignant melanoma brain metastases. Cancer 53: 2550, 1984.
29. Mandybur TI - Melanotic nerve sheath tumors. J Neurosurg 41: 187, 1974.
30. McCann WP, Weir BK, Elvidge AR - Long-term survival after removal of metastatic malignant melanoma of the brain. J Neurosurg 28: 483, 1968.
31. McNeel DP, Leavens ME - Long term survival with recurrent metastatic intracranial melanoma. J Neurosurg 29: 91, 1968.
32. Narayan RK, Rosner MJ, Povlishock JT, Girevendulis A, Becker DP - Primary dural melanoma: a clinical and morphological study. Neurosurgery 9: 710, 1981.
33. Negri L - II melanoma delle molli meningi. Arch De Vecchi 10:965, 1948.
34. Neilson JM, Moffat AD - Hypopituitarism caused by a melanoma of the pituitary gland. J Clin Path 16: 144, 1963.
35. Pappenheim E, Bhattacharji SK - Primary melanoma of the central nervous system. Arch Neurol 7: 101, 1962.
36. Pasquier B, Couderc P, Pasquier D, Panh MH, Arnoud JP - Primary malignant melanoma of the cerebellum. Cancer 41: 344, 1978.
37. Russel DS, Rubinstein LJ - Pathology of Tumors of the Nervous System. Williams and Wilkins, Baltimore, 1977, pg 55.

Publication Dates

Publication in this collection
01 June 2011
Date of issue
Dec 1989

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Albertengo JB - Melanoblastoma primitivo de fosa posterior. Anales de Cirurgia 16: 224, 1951.

[2] 2. Amer MH, Sarraf MA, Baker L.H, Vaitkvicius VK - Malignant melanoma and central nervous system metastases. Cancer 42: 660, 1978.

[3] 3. Antunes ACM, Coutinho MF, Coutinho LBM - Hemorragias em metástases intracranianas de melanoma. Arq Neuro-Psiquiat (São Paulo) 37: 180, 1979.

[4] 4. Arlant PA, Gruwnet ML, Heilbrun MP - Primary malignant melanoma of the pineal region. Surg Neurol 7: 121, 1977.

[5] 5. Arnvig J, Christensen E - Primary benignant intracranial melanoma. Acta Chir Scand 82: 217, 1939.

[6] 7. Bacchi AK, Sarkar SK, Chakraborti DP, Roy CK - Melanotic spinal schwannoma. Surg Neurol 3: 79, 1975.

[7] 8. Bailley P - Intracranial Tumors. Ed 2. Thomas, Springfield, 1948, pg 152.

[8] 9. Beatty TA - Malignant melanoma of the choroid plexus epithelium. J Neurosurg 36: 344, 1972.

[9] 10. Bergdahl L, Boquist L, Liliequist B, Thulin C, Tovi D - Primary malignant melanoma of the central nervous system. Acta Neurochir 26: 139, 1972.

[10] 11. Best PV - A medulloblastoma-like tumour with melanin formation. J Path 110: 109, 1973.

[11] 12. Bjorkesten GA - Primary melanoma of the leptomeninges. Acta Psychiat 24: 307, 1949.

[12] 13. Bullard DE, Cox EB, Seigler HF - Central nervous system metastases in malignant melanoma. Neurosurgery 8: 26, 1981.

[13] 14. Chang P, Hnapper WH - Metastatic melanoma of unknown primary. Cancer 49: 1106, 1982.

[14] 15. Das Gupta T, Brasfield R - Metastatic melanoma: a clinicopathological study. Cancer 17: 1323, 1964.

[15] 16. Dastur DK, Sinh G, Pandya SK - Melanotic tumor of the acoustic nerve. J Neurosurg 27: 166, 1967.

[16] 17. Enriquez R, Egbert B, Bullock J - Primary malignant melanoma of central nervous system. Arch Pathol 95: 392, 1973.

[17] 18. Fernandez E, Maira G, Puca A, Vignati A - Multiple intracranial metastases of malignant melanoma with long-term survival. J Neurosurg 60: 621, 1984.

[18] 19. Fischer S - Primary perivascular cerebral, cerebellar and leptomeningeal melanoma. Acta Psychiat Scand 31: 21, 1956.

[19] 20. Fowler M, Simpson DA - A malignant melanin-forming tumour of the cerebellum. J Path Bact 84: 307, 1962.

[20] 21. Gibson JB, Burrows D, Weir WP - Primary melanoma of the meninges. J Path Bact 74: 419, 1957.

[21] 22. Hayward RD - Malignant melanoma and the central nervous system. J Neurol Neurosurg Psychiat 39: 526, 1976.

[22] 23. Hodspn JJ - An intra-osseous tumour combination of biological importance-invasion of a melanotic schwannoma by a adamantinonma. J Path Bact 82: 257, 1961.

[23] 24. Humes RA, Roskamp J, Eisenbrey AB - Melanosis and hydrocephalus. J Neurosurg 61: 365, 1984.

[24] 25. Lamas E, Lobato RD, Sotelo T, Ricoy JR, Castro S - Neurocutaneous melanosis.. Acta Neurochir 36: 93, 1977.

[25] 26. Lesoin F, Leys D, Verier A, Krivosic I, Vaneecloo FM, Jomin M - Le tumeurs mélaniques primitives du system nerveux central. Rev Oto-Neuro-Ophtalm 55: 443, 1983.

[26] 27. Limas C, Tio FO - Meningeal melanocytoma (Melanotic meningioma). Cancer 30: 1286, 1972.

[27] 28. Madajewicz S, Karakousis C, West CR, Caracandas J, Avellanosa AM - Malignant melanoma brain metastases. Cancer 53: 2550, 1984.

[28] 29. Mandybur TI - Melanotic nerve sheath tumors. J Neurosurg 41: 187, 1974.

[29] 30. McCann WP, Weir BK, Elvidge AR - Long-term survival after removal of metastatic malignant melanoma of the brain. J Neurosurg 28: 483, 1968.

[30] 31. McNeel DP, Leavens ME - Long term survival with recurrent metastatic intracranial melanoma. J Neurosurg 29: 91, 1968.

[31] 32. Narayan RK, Rosner MJ, Povlishock JT, Girevendulis A, Becker DP - Primary dural melanoma: a clinical and morphological study. Neurosurgery 9: 710, 1981.

[32] 33. Negri L - II melanoma delle molli meningi. Arch De Vecchi 10:965, 1948.

[33] 34. Neilson JM, Moffat AD - Hypopituitarism caused by a melanoma of the pituitary gland. J Clin Path 16: 144, 1963.

[34] 35. Pappenheim E, Bhattacharji SK - Primary melanoma of the central nervous system. Arch Neurol 7: 101, 1962.

[35] 36. Pasquier B, Couderc P, Pasquier D, Panh MH, Arnoud JP - Primary malignant melanoma of the cerebellum. Cancer 41: 344, 1978.

[36] 37. Russel DS, Rubinstein LJ - Pathology of Tumors of the Nervous System. Williams and Wilkins, Baltimore, 1977, pg 55.