Report of a case of a 10 year old nephrotic boy that developed convulsions progressing to a coma, severe electrocardiographic and electroencephalographic changes, hyponatremia, hypokalemia, hypochloremia and alkalosis following massive diuresis secondary to the administration of ACTH. The patient remained with a convulsive disorder and a right lateral homonymous hemianopsia. The mechanism of those severe disturbances is commented on.