A 47-year-old man presented with paresthesia of the arms, disorientation and ataxia. Past medical history included alcoholism, and cholecystectomy one week prior (nitrous oxide was administrated during anesthesia). Neuroimaging revealed bilateral symmetric high signal within the dorsal columns of the cervical cord, suggesting the diagnosis of subacute combined degeneration. On cross-section images, this appearance has been described as the “inverted V sign” (Figure A, B). The laboratory test showed a low serum vitamin B12 level, confirming the diagnosis. Once the deficiency was corrected, the patient improved clinically and the spinal cord signal changes had subsided by the three-month follow-up (Figure C, D)11. Sun HY, Lee JW, Park KS, Wi JY, Kang HS. Spine MR imaging features of subacute combined degeneration patients. Eur Spine J. 2014;23(5):1052-8. https://doi.org/10.1007/s00586-014-3191-4
https://doi.org/10.1007/s00586-014-3191-...
,22. Hathout L, El-Saden S. Nitrous oxide-induced B12 deficiency myelopathy: perspectives on the clinical biochemistry of vitamin B12. J Neurol Sci. 2011;301(1-2):1-8. https://doi.org/10.1016/j.jns.2010.10.033
https://doi.org/10.1016/j.jns.2010.10.03...
,33. Gupta PK, Gupta RK, Garg RK, Rai Y, Roy B, Pandey CM et al. DTI correlates of cognition in conventional MRI of normal-appearing brain in patients with clinical features of subacute combined degeneration and biochemically proven vitamin B(12) deficiency. AJNR Am J Neuroradiol. 2014;35(5):872-77. https://doi.org/10.3174/ajnr.A3785
https://doi.org/10.3174/ajnr.A3785...
.
References
-
1Sun HY, Lee JW, Park KS, Wi JY, Kang HS. Spine MR imaging features of subacute combined degeneration patients. Eur Spine J. 2014;23(5):1052-8. https://doi.org/10.1007/s00586-014-3191-4
» https://doi.org/10.1007/s00586-014-3191-4 -
2Hathout L, El-Saden S. Nitrous oxide-induced B12 deficiency myelopathy: perspectives on the clinical biochemistry of vitamin B12. J Neurol Sci. 2011;301(1-2):1-8. https://doi.org/10.1016/j.jns.2010.10.033
» https://doi.org/10.1016/j.jns.2010.10.033 -
3Gupta PK, Gupta RK, Garg RK, Rai Y, Roy B, Pandey CM et al. DTI correlates of cognition in conventional MRI of normal-appearing brain in patients with clinical features of subacute combined degeneration and biochemically proven vitamin B(12) deficiency. AJNR Am J Neuroradiol. 2014;35(5):872-77. https://doi.org/10.3174/ajnr.A3785
» https://doi.org/10.3174/ajnr.A3785
Publication Dates
-
Publication in this collection
July 2017
History
-
Received
10 Oct 2016 -
Reviewed
01 Mar 2017 -
Accepted
14 Mar 2017