A case of cryptococcal meningoencephalitis occurrying in a 26-year-old white man disclosing clinical as well radiological features of a expanding process localized in the right cerebral hemisphere is reported. A definitive diagnosis was established through histopathologic examination following right fronto-temporo-parietal exploratory and decompressive craniotomy. Cryptococcus neo-formans was easily demonstrated in the leptomeninges as well as in cystic spaces in the brain substance.