Coherence of brain electrical activity: a quality of life indicator
					in Alzheimer’s disease?Coerência da atividade elétrica cerebral: indicador da
					qualidade de vida na doença de Alzheimer?

Fonseca, Lineu Corrêa; Tedrus, Gloria M. A. S.; Rezende, Ana Laura R. A.; Giordano, Heitor F.

doi:10.1590/0004-282X20150035

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Sumário

ARTICLES • Arq. Neuro-Psiquiatr. 73 (5) • May 2015 • https://doi.org/10.1590/0004-282X20150035 copy

Coherence of brain electrical activity: a quality of life indicator in Alzheimer’s disease?Coerência da atividade elétrica cerebral: indicador da qualidade de vida na doença de Alzheimer?

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective

To investigate the relationships between quality of life (QOL) and clinical and electroencephalogram (EEG) aspects in patients with Alzheimer’s disease (AD).

Method

Twenty-eight patients with mild or moderate AD, 31 with Parkinson’s disease (PD), and 27 normal controls (NC) were submitted to: CERAD neuropsychological battery, Hamilton Depression and Anxiety Rating Scales, Functional Activities Questionnaire, QOL scale for patients with AD, and quantitative EEG measures.

Results

AD and PD patients had similar QOL (31.0 ± 5.8; 31.7 ± 4.8, respectively), worse than that of NC (37.5 ± 6.3). AD patients had lower global interhemispheric theta coherence (0.49 ± 0.04; 0.52 ± 0.05; 0.52 ± 0.05; respectively) than PD and NC. Multiple linear regression for QOL of AD patients revealed that global interhemispheric theta coherence, and Hamilton depression scores were significant factors (coefficients; 58.2 and -0.27, respectively; R², 0.377).

Conclusion

Interhemispheric coherence correlates with QOL regardless of cognitive and functional variables and seems to be a neurophysiological indicator of QOL in AD patients.

Alzheimer’s disease; EEG; quality of life; Parkinson’s disease

Subjects	AD (N = 28)	PD (N = 31)	NC (N = 27)	Comparison (AD x NC)	p-value (AD x PD)
Age (years)	77.1 (5.6)	68.8 (10.4)	74.0 (6.5)	0.063	0.000*
Male/Female	9/19	21/10	10/17	0.635	0.004**
Education level (years)	3.2 (2.4)	4.2 (3.2)	6.5 (4.5)	0.001*	0.214
Mini-Mental State Examination	15.8 (3.9)	24.0 (4.7)	26.8 (2.0)	0.000*	0.000*
Verbal fluency	5.8 (3.4)	10.7 (4.6)	14.4 (3.9)	0.000*	0.000*
Pfeffer questionnaire	18.4 (9.5)	4.6 (7.2)	0.5 (1.5)	0.000*	0.000*
Neuropsychiatric Inventory	19.0 (15.6)	14.2 (13.6)	2.9 (5.7)	0.000*	0.839
Hamilton Depression Scale	12.8 (7.3)	10.1 (7.9)	4.6 (4.3)	0.000*	0.171
QOL-AD	31.0 (5.8)	31.7 (4.8)	37.5 (6.3)	0.000*	0.673

Coherences	AD (N = 28)	PD (N = 31)	NC (N = 27)	Comparison (AD x NC)	p-value (AD x PD)
Delta	0.546 (0.050)	0.576 (0.064)	0.575 (0.064)	0.081	0.061
Theta	0.492 (0.043)	0.525 (0.055)	0.521 (0.053)	0.044*	0.021*
Alpha	0.474 (0.057)	0.505 (0.041)	0.526 (0.046)	0.000*	0.017*
Beta	0.414 (0.050)	0.449 (0.068)	0.443 (0.054)	0.046*	0.026*

Clinical-EEG variables	Bivariate QOL-AD relationships
	AD (N = 28)		PD (N = 31)		NC (N = 27)
	CC	p	CC	p	CC	p
Age	0.229	0.241	-0.172	0.354	0.497	0.008*
Education Level	0.075	0.706	-0.193	0.307	0.338	0.085
Mini-Mental State Examination	0.092	0.643	0.097	0.469	-0.252	0.214
Verbal fluency	0.471	0.011*	-0.043	0.744	-0.030	0.884
Pfeffer Questionnaire	-0.251	0.197	-0.069	0.618	-0.263	0.185
Neuropsychiatric Inventory	-0.096	0.627	-0.541	0.002*	-0.382	0.049*
Hamilton Depression Scale	-0.458	0.014*	-0.457	0.001*	-0.610	0.001*
Interhemispheric coherence
Delta	0.195	0.321	0.007	0.959	0.060	0.766
Theta	0.517	0.005*	0.068	0.597	-0.126	0.531
Alpha	-0.019	0.923	0.219	0.091	-0.228	0.252
Beta	0.075	0.703	0.174	0.177	-0.024	0.905

Significant predictor	R²	Coefficient	Standardized coefficient	95%CI for coefficient	p-value	Cohen’s f²
	0.377					0.605
Interhemispheric theta coherence		58.229	0.425	11.962 104.496	0.016
Hamilton Depression Scale		-0.274	-0.345	-0.541 -0.006	0.046

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[1] Correspondence: Lineu Corrêa Fonseca; Pontifícia Universidade Católica de Campinas, Faculdade de Medicina, Disciplina de Neurologia; Rua Sebastião de Souza, 205 - cj. 122; 13013-910 Campinas SP, Brasil; E-mail: lineu.fonseca@uol.com.br