Postuma et al.3131. Postuma RB, Montplaisir J, Lanfranchi P, Blais H, Rompre S, Colombo R, et al. Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. Mov Disord. 2011 Jul;26(8):1529-33. https://doi.org/10.1002/mds.23677 https://doi.org/10.1002/mds.23677...
|
2011 |
Canada |
53 |
60 |
|
Cardiac autonomic denervation was not associated with PD; rather, it was associated with RBD. |
Kim et al.2121. Kim YE, Jeon BS. Clinical implication of REM sleep behavior disorder in Parkinson's disease. J Parkinsons Dis. 2014;4(2):237-44. https://doi.org/10.3233/JPD-130293 https://doi.org/10.3233/JPD-130293...
|
2014 |
Review |
4,089 |
20–72 |
|
RBD was associated with hallucinations and dementia. |
Mahajan et al.55. Mahajan A, Rosenthal LS, Gamaldo C, Salas RE, Pontone GM, McCoy A, et al. REM sleep behavior and motor findings in Parkinson's disease: a cross-sectional analysis. Tremor Other Hyperkinet Mov (N Y). 2014 Jun;4:245. https://doi.org/10.7916/D84B2ZDF https://doi.org/10.7916/D84B2ZDF...
|
2014 |
USA |
418 |
27 |
Patients with RBD were 1.66 times more likely to present worse motor symptoms. |
No depression differences between patients with and without RBD. |
Fantini et al.3232. Fantini ML, Macedo L, Zibetti M, Sarchioto M, Vidal T, Pereira B, et al. Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder. J Neurol Neurosurg Psychiatry. 2015 Feb;86(2):174-9. https://doi.org/10.1136/jnnp-2014-307904 https://doi.org/10.1136/jnnp-2014-307904...
|
2015 |
Multicenter |
216 |
53.0 |
|
RBD was associated with an increased risk of developing impulse control disorders. |
Cui et al.3333. Cui SS, Du JJ, Fu R, Lin YQ, Huang P, He YC, et al. Prevalence and risk factors for depression and anxiety in Chinese patients with Parkinson disease. BMC Geriatr. 2017 Nov;17:270. https://doi.org/10.1186/s12877-017-0666-2 https://doi.org/10.1186/s12877-017-0666-...
|
2017 |
China |
403 |
|
|
RBD was a risk factor for anxiety development (OR: 1.029 and p-value: 0.037). |
Liu et al.44. Liu Y, Zhu XY, Zhang XJ, Kuo SH, Ondo WG, Wu YC. Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder. Transl Neurodegener. 2017 Dec;6:35. https://doi.org/10.1186/s40035-017-0105-5 https://doi.org/10.1186/s40035-017-0105-...
|
2017 |
China |
141 |
21.3 |
|
Patients with RBD had more anxiety, depression, constipation, hallucinations, and a higher prevalence of orthostatic hypotension. |
Jozwiak et al.3434. Jozwiak N, Postuma RB, Montplaisir J, Latreille V, Panisset M, Chouinard S, et al. REM sleep behavior disorder and cognitive impairment in Parkinson's disease. Sleep. 2017 Aug;40(8):zsx101. https://doi.org/10.1093/sleep/zsx101 https://doi.org/10.1093/sleep/zsx101...
|
2017 |
Canada |
93 |
56.9 |
|
RBD was associated with greater cognitive impairment and a higher diagnosis frequency of mild cognitive impairment. |
Pagano et al.22. Pagano G, De Micco R, Yousaf T, Wilson H, Chandra A, Politis M. REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease. Neurology. 2018 Sep;91(10):e894-e905. https://doi.org/10.1212/WNL.0000000000006134 https://doi.org/10.1212/WNL.000000000000...
|
2018 |
Multicenter |
421 |
37.5 |
RBD was associated with a faster progression of PD motor symptoms. |
RBD was associated with a greater risk of cognitive decline and a higher number of non-motor symptoms associated with PD, including hallucinations, pain, fatigue, constipation, and urinary problems. |
Kang et al.3535. Kang SH, Yoon IY, Lee SD, Han JW, Kim TH, Kim KW. REM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristics. Sleep. 2013 Aug;36(8):1147-52. https://doi.org/10.5665/sleep.2874 https://doi.org/10.5665/sleep.2874...
|
2013 |
Systematic review |
|
|
Higher frequency of RBD in the predominant non-tremor PD phenotype. |
RBD was a risk factor for the development of dementia and hallucinations. |
Kim et al.3636. Kim Y, Kim YE, Park EO, Shin CW, Kim HJ, Jeon B. REM sleep behavior disorder portends poor prognosis in Parkinson's disease: A systematic review. J Clin Neurosci. 2018 Jan;47:6-13. https://doi.org/10.1016/j.jocn.2017.09.019 https://doi.org/10.1016/j.jocn.2017.09.0...
|
2018 |
Systematic review |
|
|
|
RBD in PD patients was associated with greater disease severity and increased mortality risk; further, the authors suggested that RBD could be a PD subtype marker. |
Liu et al.3737. Liu H, Ou R, Wei Q, Hou Y, Cao B, Zhao B, et al. Rapid eye movement behavior disorder in drug-naive patients with Parkinson's disease. J Clin Neurosci. 2019 Jan;59:254-8. https://doi.org/10.1016/j.jocn.2018.07.007 https://doi.org/10.1016/j.jocn.2018.07.0...
|
2019 |
China |
158 |
19.6 |
|
RBD was associated with cognitive decline, other sleep disorders, and anxiety. |
Banks et al.3838. Banks SJ, Bayram E, Shan G, LaBelle DR, Bluett B. Non-motor predictors of freezing of gait in Parkinson's disease. Gait Posture. 2019 Feb;68:311-6. https://doi.org/10.1016/j.gaitpost.2018.12.009 https://doi.org/10.1016/j.gaitpost.2018....
|
2019 |
USA |
100 |
|
|
RBD was associated with gait motor complications. |
Baig et al.33. Baig F, Kelly MJ, Lawton MA, Ruffmann C, Rolinski M, Klein JC, et al. Impulse control disorders in Parkinson and RBD: A longitudinal study of severity. Neurology. 2019 Aug;93(7):e675-e687. https://doi.org/10.1212/WNL.0000000000007942 https://doi.org/10.1212/WNL.000000000000...
|
2019 |
UK |
921 (in the first assessment) |
|
|
RBD was not associated with an increased risk of developing impulse control disorders. |
Bargiotas et al.3939. Bargiotas P, Ntafouli M, Lachenmayer ML, Krack P, Schupbach WMM, Bassetti CLA. Apathy in Parkinson's disease with REM sleep behavior disorder. J Neurol Sci. 2019 Apr;399:194-8. https://doi.org/10.1016/j.jns.2019.02.028 https://doi.org/10.1016/j.jns.2019.02.02...
|
2019 |
Switzerland |
64 |
40.0 |
|
RBD was associated with apathy and increased depressive symptom severity. |
Pilotto et al.4040. Pilotto A, Romagnolo A, Tuazon JA, Vizcarra JA, Marsili L, Zibetti M, et al. Orthostatic hypotension and REM sleep behaviour disorder: impact on clinical outcomes in alpha-synucleinopathies. J Neurol Neurosurg Psychiatry. 2019 Nov;90(11):1257-63. https://doi.org/10.1136/jnnp-2019-320846 https://doi.org/10.1136/jnnp-2019-320846...
|
2019 |
Systematic review |
|
|
|
Patients with PD and RBD had an increased risk of cognitive decline. The authors proposed the existence of a malignant PD phenotype associated with RBD and orthostatic hypotension, which could be characterized by faster progression of cognitive decline and postural instability. |