Andersen et al. (2017)2020 Andersen G, Heje K, Buch AE, Vissing J. High-intensity interval training in facioscapulohumeral muscular dystrophy type 1: a randomized clinical trial. J Neurol 2017;264(06):1099–1106
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FSHD1 |
(13) EG: N = 6 CG: N = 7 |
EG: 53 ± 15 (26–67) CG: 46 ± 9 (32–59) |
FSHD score = 1–11 |
EG: HIT (cycle-ergometer) CG: Usual care |
8 weeks (3 × 10-min) |
6MWT 5STS IPAQ |
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Dal Bello-Haas et al. (2007)2121 Bello-Haas VD, Florence JM, Kloos AD, et al. A randomized controlled trial of resistance exercise in individuals with ALS. Neurology 2007;68(23):2003–2007
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ALS (ALSFRS early stage) |
(27) EG = 13 CG = 14 |
not informed |
not informed |
EG: stretching exercise program (as CG) and an individualized UE and LE moderate-load intensity resistance exercise program CG: Usual care UE and LE stretching exercises |
6 months |
ALSFRS-R |
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Lindeman et al. (1995)2222 Lindeman E, Leffers P, Spaans F, et al. Strength training in patients with myotonic dystrophy and hereditary motor and sensory neuropathy: a randomized clinical trial. Arch Phys Med Rehabil 1995;76(07):612–620
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MD HMSN (types I or II) |
(62) MyD = 33 HMSN = 29 |
MyD EG: 40 ± 11 CG: 37 ± 10 NHMS EG:35 ± 10 CG: 38 ± 11 |
not informed |
EG: Strength training with weights of the proximal lower extremity muscles CG: nonexercising (CG were encouraged to refrain from training |
3x week for 24 weeks |
Time scored activities performed as fast as possible: ascending and descending stairs, rising from a chair, rising from supine on a physical exercise table and walking 50m 6MWT WOMAC functional part of the Western Ontario and McMaster Universit |
SIP-68 |
|
SIP-68: Social participation |
Nakajima et al. (2021)2323 Nakajima T, Sankai Y, Takata S, et al. Cybernic treatment with wearable cyborg Hybrid Assistive Limb (HAL) improves ambulatory function in patients with slowly progressive rare neuromuscular diseases: a multicentre, randomised, controlled crossover trial for efficacy and safety (NCY-3001). Orphanet J Rare Dis 2021; 16(01):304
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NMD |
(24) EG = 11 CG = 13 |
CG= 55,5 ± 7.2 EG = 56 ± 13.2 |
no rapid changes in gait symptoms for three months prior to the start of the trial |
GE: Walking program with partial body support and exoeskeletal device for LE GC: Walking program with partial body support (30min) |
13 weeks (9 sessions) |
2MWT (gait distance) 10MWT (speed) Barthel index |
Barthel index |
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Okkersen et al. (2018)2424 Okkersen K, Jimenez-Moreno C, Wenninger S, et al; OPTIMISTIC consortium. Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial. Lancet Neurol 2018;17(08):671–680
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MD1 |
(255) EG = 128 CG = 127 |
EG: 44,8 ± 11,7 CG: 46,4 ± 11,3 |
|
EG: Cognitive behavioural therapy intervention and usual care or aerobic exercise CG: Usual care |
10 months (10–14 sessions) |
DM1-Activ-C 6MWT MDHI |
DM1-Activ-C |
MDHI |
DM1-Activ-C MDHI |
Öksüz et al.(2011)2525 Öksüz Ç, Akel BS, Bumin G. Effect of occupational therapy on activity level and occupational performance in patients with neuromuscular disease. Fizyoterapi Rehabilitasyon 2011;22 (03):231–239
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NMD |
(60) EG = 30 CG = 30 |
EG: 37.5 ± 15.1 CG:38.7 ± 15.4 |
can stand in long leg braces but unable to walk even with assistance and who uses a wheelchair full time |
EG: Client centred occupational therapy program and conventional therapeutic home exercise program by a physiotherapist CG: Conventional physiotherapeutic home exercise program by a physiotherapist |
6 months |
FIM DASH |
FIM |
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COPM |
Raglio et al. (2016)2626 Raglio A, Giovanazzi E, Pain D, et al. Active music therapy approach in amyotrophic lateral sclerosis: a randomized-controlled trial. Int J Rehabil Res 2016;39(04):365–367
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ALS |
(30) EG = 15 CG = 15 |
EG: 62.9 ± 9.83 CG: 65.1 ± 12.10 |
mild–moderate disability (ALS Functional Rating Scale- Revised ≤40) |
EG: Active Music Therapy and usual care CG: Usual care |
12 sessions, 3x/weeks (4 weeks) |
ALSFRS-R |
ALSFRS-R |
MTRS |
|
Sherief et al. (2021)2727 Sherief AEAA, Abd ElAziz HG, Ali MS. Efficacy of two intervention approaches on functional walking capacity and balance in children with Duchene muscular dystrophy. J Musculoskelet Neuronal Interact 2021;21(03):343–350
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DMD |
(30) EG = 15 CG = 15 |
EG: 8.49 ± 0.83 CG: 8.34 ± 0.88 |
Able to walk alone level I and II of Ambulation function classification system for DMD (AFCSD) |
EG: physical therapy program and aerobic exercise training by treadmill CG: physical therapy program and aerobic exercise training by bicycle ergometer |
20 min, 3x/week, 3 months 20 min, 3x/week, 3 months |
6MWT |
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Van Groenestijn et al. (2019)2828 van Groenestijn AC, Schröder CD, van Eijk RPA, et al. Aerobic Exercise Therapy in Ambulatory Patients With ALS: A Randomized Controlled Trial. Neurorehabil Neural Repair 2019;33(02): 153–164
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ALS |
(57) EG = 27 CG = 30 |
EG: 60.9 ± 10.0 CG: 59.9 ± 10.7 |
life expectancy longer than 1 year; ability to walk with or without walking aid (≥10 min); and ability to cycle on a cycle ergometer (≥15 min) |
EG: Aerobic cycling exercise program (50-75% HRR) and usual care CG: Usual care |
16 weeks |
ALSFRS-R TUG |
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SIP-68 IPAQ |
Veenhuizen et al. (2019)2929 Veenhuizen Y, Cup EHC, Jonker MA, et al. Self-management program improves participation in patients with neuromuscular disease: A randomized controlled trial. Neurology 2019;93(18): e1720–e1731
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NMD |
(53) EG = 29 CG = 24 |
EG: 52 (37-63) CG: 50 (41-60) |
not informed |
EG: Aerobic exercise training (50-70% HRR) and self-management strategies CG: Usual care |
16 weeks 3x week of 30 min |
6MWT |
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COPM |
Voet et al. (2014)3030 Voet N, Bleijenberg G, Hendriks J, et al. Both aerobic exercise and cognitive-behavioral therapy reduce chronic fatigue in FSHD: an RCT. Neurology 2014;83(21):1914–1922
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FSHD1 |
(57) EG1 = 20 EG2 = 13 CG = 24 |
EG1: 59 (21–68) EG2:49 (24–69) CG: 52 (20–79) |
Able to walk independently (ankle-foot orthoses and canes are accepted) |
EG1: Aerobic cycling exercise training (50-65% HRR) EG2: Cognitive-behavioral therapy CG: Usual care |
30 min, 3x/week, 16 weeks (GE1) minimum of 3 session (GE2) |
6MWT CIS-activity |
SIP-68 |
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SIP-68 |
Zivi et al. (2018)3131 Zivi I, Maffia S, Ferrari V, et al. Effectiveness of aquatic versus land physiotherapy in the treatment of peripheral neuropathies: a randomized controlled trial. Clin Rehabil 2018;32(05):663–670
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Peripheral neuropathies |
(40) EG = 21 CG = 19 |
EG: 66.3 ± 13.0 CG: 71.8 ± 7.7 |
ability to maintain the upright position and to walk even if with assistance |
EG: Gait and balance of aquatic physiotherapy CG: Gait and balance of on-land training |
4 weeks of daily sessions of usual physiotherapy 3x week of specific treatment (aquatic vs. on-land) |
DGI BBS FIM Functional Ambulation Classification |
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