Inhibition of peridural fibrosis after laminectomy using biological sheet in rat model

THESES

Inhibition of peridural fibrosis after laminectomy using biological sheet in rat model (Abstract)^*. Thesis. São Paulo, 2003

Marco Antonio Herculano

^{Correspondence}

OBJECTIVE: To investigate the use of a biological membrane composed by a decalcified bovine cortical osseous, in surgeries of spinal column in rats, to treat the osseous defect, minimizing or blocking the muscular tissue herniation into the rachidian channel, reducing the fibrous tissue formed at post-operative period and yet to evaluate the material biocompatibility.

METHOD: The biological decalcified bovine cortical osseous – which has wide utility in odontology to cover dental implants or as a biological obstacle to be used in Buccomaxilary Orthopedics and Traumatology, Esthetic and Repairer Plastic Surgery, Facial Surgery and Oncology – was used in lombar and thoraxic laminectomies, performed in Wistar-EPM rats, which were sacrified after eight, sixteen and twenty-four weeks and then the surgical samples were removed to be submitted to histopathological study.

RESULTS: The results obtained from the microscopic analysis of the material submitted to hematoxylin-eosin in the three groups above were separated according to the sacrifice time and presence or absence of implant and both presented similar aspect, without significant statistical differences, but with some percentages showing significant differences, which suggests a behaviour difference among the groups in respect to the presence or absence of tissue reconstitution.

CONCLUSION: The biological lyophilizated membrane of bovine cortical osseous avoided the muscular tissue herniation into the rachidian channel and was totally reabsorbed in all analysed samples which proves its biocompatibility and favouring the osseous neoformation and avoiding adherences.

Key words: laminectomy, fibrosis, bovine osteal cortex, biological membrane.

Correspondence to

Rua Escolástica de Toledo Ponte 51

Jardim Maria Luiza

13209-290

Jundiaí SP, Brasil

*

Estudo do uso de membrana biológica em ratos na prevenção de fibrose após laminectomia (Resumo). Tese de Doutorado, Universidade Federal de São Paulo – Escola Paulista de Medicina (Área Neurocirurgia). Orientador: Oswaldo Inácio de Tella Jr. Co-orientadores: Mirto Nelso Prandini; Maria Teresa de Seixas Alves.

Publication Dates

• Publication in this collection
  25 Apr 2006
• Date of issue
  Dec 2004