1 |
de l'Escalopier et al., 20191111. de l’Escalopier N, Salga M, Gatin L, Genêt F, Denormandie P. Resection of heterotopic ossification around the hip after trauma. EFORT Open Rev. 2019;4(6):263-8. |
Retrospective cohort |
377 (104 SCI) |
|
Surgical resection |
Surgical resection in symptomatic patients. Minimal resection to achieve functional ROM. Post-procedure physical therapy and pre-procedure ATB |
2 |
Ploumis et al., 20151212. Ploumis A, Donovan JM, Olurinde MO, Clark DM, Wu JC, Sohn DJ, O’Connor KC. Association between alendronate, serum alkaline phosphatase level, and heterotopic ossification in individuals with spinal cord injury. J Spinal Cord Med. 2015;38(2):193-8. |
Retrospective control case |
125 |
174 |
Alendronate |
Administration of alendronate 70 mg per week, averaging 38.17 ± 57.89 weeks. The patients were followed for an average of 626.72 ± 620.49 days. |
3 |
Ester et al., 20221313. Ester EC, Gallaher IS, Jones DA, Lynch JG. The role of radiation therapy in the management of neurogenic heterotopic ossification. Oncology. 2022;28(1S):1-10. |
Retrospective cohort |
3 SCI and 1 CCT |
|
Radiotherapy (8 Gy) + resection + NSAIDs Radiotherapy (8 Gy) + etidronate |
Irradiated 3 hips, post resection, with 8 Gy, followed by 6 weeks of 25 mg of indomethacin, 3 times/day. Three hips and 2 elbows were irradiated + etidronate, no surgery. |
4 |
Honore et al., 20201414. Honore T, Salga M, Grelier A, Denormandie P, Genet G, Labib A, et al. Effectiveness of radiotherapy to prevent recurrence of heterotopic ossification in patients with spinal cord injury and traumatic head injury: a retrospective case-controlled study. J Rehabil Med. 2020;52(5):jrm00066. |
Retrospective control case |
11 SCI and 8 CCT |
76 (SCI or CCT) |
Radiotherapy (7.5 Gy) |
RT was performed with 7.5 Gy perioperatively to prevent recurrence. |
5 |
Zakrasek et al., 20191515. Zakrasek EC, Yurkiewicz SM, Dirlikov B, Pence BT, Crew JD. Use of nonsteroidal anti-inflammatory drugs to prevent heterotopic ossification after spinal cord injury: a retrospective chart review. Spinal Cord. 2019;57(3):214-20. |
Retrospective control case |
27 |
81 |
NSAIDs |
Use of NSAIDs (indomethacin 25 mg 3 times/day or celecoxib 200 mg/day) for 15 days or more. Followed up for an average of 63 days, being evaluated an average of 21 days after trauma. |
6 |
Romero-Muñoz et al., 20181616. Romero-Muñoz LM, Barriga-Martín A, DeJuan-García J. Surgical treatment of hip ankylosis due to heterotopic ossification secondary to spinal cord injury. Rev Esp Cir Ortop Traumatol. 2018;62(6):458-66. |
Retrospective cohort |
20 |
|
Surgical resection + NSAIDs |
Surgical resection of HO in 16 cases and Girdlestone in 4 cases. Goal of surgery: gain 90° of flexion and 20° of abduction. Physical therapy + celecoxib 200 mg/day for 4 weeks after the procedure. |
7 |
Müseler et al., 20171717. Müseler AC, Grasmücke D, Jansen O, Aach M, Meindl R, Schildhauer TA, Citak M. In-hospital outcomes following single-dose radiation therapy in the treatment of heterotopic ossification of the hip following spinal cord injury - an analysis of 444 cases. Spinal Cord. 2017;55(3):244-6. |
Retrospective cohort |
244 |
|
Radiotherapy (7 Gy) |
Single radiation dose of 7 Gy in patients detected with HO (via biweekly US screening). After an average of 4.9 days after diagnosis, treatment was performed, which was on average 63.2 days after SCI. |
8 |
Citak et al., 20161818. Citak M, Grasmücke D, Cruciger O, Königshausen M, Meindl R, Schildhauer TA, Aach M. Heterotopic ossification of the shoulder joint following spinal cord injury: an analysis of 21 cases after single-dose radiation therapy. Spinal Cord. 2016;54(4):303-5. |
Retrospective cohort |
13 |
|
Single radiation dose (7 Gy, 6 Gy in two cases) |
Single radiation dose in patients with HO (via biweekly US screening). |