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Organic and inorganic bone graft use in rabbits' radius surgical fractures rapair: an experimental and comparative study

Study carried out with the purpose of evaluating the outcomes of rabbits’ radius fracture unions by using both organic and mineral bone grafts. For the study, 20 adult animals, both males and females, weighing around 3.0 and 3.5 kg, sourced by Maranhão State University Animal Lab were employed. The animals were divided into two similar groups and subjected to a simple complete transverse osteotomy on the right radius diaphysis, with 1 cm of bone fragment being removed. In group I (G1), an organic bone fragment from the iliac wing of the same animal was placed at the osteotomy site; in group II (G2), an Osteosynt inorganic bone graft, composed by synthetic hydroxyapatite and calcium phosphate was placed. The groups were subdivided into 5 periods (P15 = 15 days, P30 = 30 days, P45 = 45 days, P60 = 60 days, P75 = 75 days) for evaluating x-ray and histological aspects of the osteotomy site (surgical fracture) aiming to check local bone union process. X-ray studies showed that G2 developed a faster repair process in all observation periods when compared to G1. This fact was confirmed by histological evaluation. We conclude that the inorganic bone graft may be routinely used in orthopaedic surgery, providing an early bone healing.

Hydroxyapatite; Rabbit; Radiology; Histology


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