OBJECTIVE: To evaluate the morphological effects of phenobarbital treatment on new bone formation and on bone marrow biomechanics in Wistar rats. METHODS: We used ten rats that were divided into two groups: control (CT) and phenobarbital (FE). The FE group received daily doses of phenobarbital 0.035 ml / kg intramuscularly for 60 days. The CT group received the same dose and route of administration of 0.9% saline solution. After 30 days, we introduced a bone defect in the parietal bone and implanted porous hydroxyapatite (HAP) in cavities in the tibia. After surgery, we continued the protocols until the end of 60 days when the rats were euthanized, and the bones were collected. RESULTS: The volume of bone formed around HAP in parietal defect and biomechanical findings were lower in animals receiving FE compared to CT. CONCLUSION: Prolonged use of phenobarbital interferes with bone repair after injury, decreasing the osseointegration of HAP implants and making bones less resistant.
Durapatite; Osseointegration; Osteogenesis; Phenobarbital/adverse effects; Bone and bones/drug effects
