Pain induction by chemotherapy medication docetaxel in women with breast cancer

Longitudinal study involving 17 women with breast cancer under treatment using Docetaxel. The patients’ pain was assessed during three chemotherapy cycles, using the tools McGill Pain Questionnaire (Br-MPQ) and the Brief Pain Inventory (BPI). Spearman’s correlation and the Mann-Whitney test were used.

Results

The mean pain score increased in all variables of the BPI. When comparing the total coefficients on the Pain Assessment Index, 0.20; 0.33 and 0.24 were found in the first, second and third assessment, showing a correlation between the pain intensity and the interference in all daily activities on the BPI for the second assessment.

Conclusion

The occurrence of pain increased, compromising the participating women’s activities of daily living.

Breast neoplasms/drug therapy; Pain/etiology; Pain/chemically induced; Antineoplastic agents/adverse effects; Pain measurement

Characteristics	n(%)
Age range
30-40	3(17.65)
41-50	3(17.65)
51-60	9(52.94)
≥61	2(11.76)
Marital status
Single	1(5.88)
Married	12(70.50)
Separated/divorced	2(11.76)
Widowed	2(11.76)
Skin color
White	7(41.17)
Black	4(23.52)
Mulatto	6(35.29)
Education, years
<9	10(58.88)
≥9	7(41.17)
Income, minimum wage*
≤1	5(29.41)
>1-2	4(23.52)
>2-3	4(23.52)
>3-5	2(11.76)
>5	2(11.76)
Clinical staging
IIA	4(23.52)
IIB	6(35.29)
IIIA	5(29.41)
IIIB	2(11.76)
Use of analgesic medication
First assessment	5(29.41)
Second assessment	8(47)
Third assessment	14(82.32)

Variables			Worst pain in the last 21 days
Variables	First assessment		Second assessment		Third assessment
Activities of Daily Living	Coefficient	p-value*	Coefficient	p-value*	Coefficient	p-value*
General assessment	0.770	0.000*	0.589	0.013*	0.704	0.002*
Mood	0.598	0.011*	0.488	0.047*	0.825	0.000*
Ability to walk	0.677	0.003*	0.833	0.000*	0.607	0.010*
Work	0.659	0.004*	0.698	0.002*	0.499	0.041*
Relationship with other people	0.309	0.121	0.567	0.0188*	0.606	0.010*
Sleep	0.393	0.119	0.617	0.008*	0.679	0.003*
Appreciate life	0.702	0.002*	0.572	0.016*	0.370	0.144

Variables	First assessment		Second assessment		Third assessment
Variables	PRI	NWC	PRI	NWC	PRI	NWC
Sensory	0.19	3.41	0.34	5.65	0.24	4.53
Affective	0.20	1.82	0.35	3.12	0.28	2.53
Subjective assessment	0.30	0.65	0.51	1	0.38	1
Mixed	0.10	0.76	0.12	1.24	0.07	0.82
Total	0.20	6.63	0.33	10.98	0.24	8.86

Escola Paulista de Enfermagem, Universidade Federal de São Paulo R. Napoleão de Barros, 754, 04024-002 São Paulo - SP/Brasil, Tel./Fax: (55 11) 5576 4430 - São Paulo - SP - Brazil
E-mail: actapaulista@unifesp.br

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[1] Corresponding author Anna Cláudia Yokoyama dos Anjos Pará Avenue, 1720, 38400-902, Campus Umuarama, Uberlândia, MG, Brazil. annaclaudia1971@gmail.com