Motility |
Sperm |
Proteins: |
Rams |
Zhu et al. (2020)Zhu W, Zhang Y, Ren C, Cheng X, Chen J, Ge Z, Sun ZP, Zhuo X, Sun FF, Chen YL, Jia XJ, Zhang Z. Identification of proteomic markers for ram spermatozoa motility using a tandem mass tag (TMT) approach. J Proteomics. 2020;210:103438. http://doi.org/10.1016/j.jprot.2019.103438. PMid:31271902. http://doi.org/10.1016/j.jprot.2019.1034...
|
Phosphatidylethanolamine binding protein 4, Spermatogenesis associated 18, Carboxypeptidase, Acrosin |
Proteins:
|
Horses |
Gaitskell-Phillips et al. (2021a)Gaitskell-Phillips G, Martín-Cano FE, Ortiz-Rodríguez JM, Silva-Rodríguez A, Gil MC, Ortega-ferrusola C, Peña FJ. Differences in the proteome of stallion spermatozoa explain stallion-to-stallion variability in sperm quality post-thaw†. Biol Reprod. 2021a;104(5):1097-113. http://doi.org/10.1093/biolre/ioab003. PMid:33438027. http://doi.org/10.1093/biolre/ioab003...
|
Mannosidase alpha class 2C member 1, Ubiquinone 1 alpha sucomplex subunit 9-like protein, isoleucyl-tRNA synthetase2, mitochondrial acethyl-CoA acetyl transferase 1, Latherin, Ubiquitin-specific peptidase 43 |
Proteins:
|
Horses |
Gaitskell-Phillips et al. (2021b)Gaitskell-Phillips G, Martín-Cano FE, Ortiz-Rodríguez JM, Silva-Rodríguez A, Da Silva-Álvarez E, Rojo-Domínguez P, Tapia JA, Gil MC, Ortega-Ferrusola C, Peña FJ. Proteins involved in mitochondrial metabolic functions and fertilization predominate in stallions with better motility. J Proteomics. 2021b;247:104335. http://doi.org/10.1016/j.jprot.2021.104335. PMid:34298182. http://doi.org/10.1016/j.jprot.2021.1043...
|
Hexokinase 1, Aconitase hydratase mitochondrial, Phosphoinositide phospholipase C, Elongation factor Tu, F actin capping protein subunit alpha |
Metabolites:
|
Bucks |
Yuan et al. (2023a)Yuan Y, Yu M, Chen L, Ren X, Qu Y, Shari A, Li G. Comparative analysis of different metabolites in semen of Guanzhong dairy goats with different motility rates. Theriogenology. 2023a;210:53-61. http://doi.org/10.1016/j.theriogenology.2023.07.009. PMid:37473596. http://doi.org/10.1016/j.theriogenology....
|
Butyric acid, 1-(2-Methoxy-13-methyl-pentadecanyl)-sn-glycero-3-phosphoetanolamine, 2-O-benzoyl-D-glucose, Trehalulose, Glutamylphenylalanine, Vulgaxanthin-I |
Transcripts:
|
Bulls |
Ganguly et al. (2013)Ganguly I, Gaur GK, Kumar S, Mandal DK, Kumar M, Singh U, Kumar S, Sharma A. Differential expression of protamine 1 and 2 genes in mature spermatozoa of normal and motility impaired semen producing crossbred Frieswal (HF×Sahiwal) bulls. Res Vet Sci. 2013;94(2):256-62. http://doi.org/10.1016/j.rvsc.2012.09.001. PMid:23044178. http://doi.org/10.1016/j.rvsc.2012.09.00...
|
PRM1 mRNAs |
Liquid preservation ability/Freezability |
Proteins: NUDFB8, SDHC, PDIA4, HSPB1 |
Bucks |
Sun et al. (2023)Sun P, Zhang G, Xian M, Zhang G, Wen F, Hu Z, Hu J. Proteomic analysis of frozen–thawed spermatozoa with different levels of freezability in dairy goats. Int J Mol Sci. 2023;24(21):15550. http://doi.org/10.3390/ijms242115550. PMid:37958534. http://doi.org/10.3390/ijms242115550...
|
Proteins:
|
Boars |
Song et al. (2024)Song C, Zhang Z, Wei Y, Dou Y, Qi K, Li X, Yang F, Li X, Wang K, Qiao R, Han X. Proteomic analysis of boar sperm with differential ability of liquid preservation at 17°C. Theriogenology. 2024;215:103-12. http://doi.org/10.1016/j.theriogenology.2023.11.017. PMid:38029685. http://doi.org/10.1016/j.theriogenology....
|
GPX5, GLRX, ENO4, QPCT, BBS7, OXR1, DHRS4, AP2S1 |
Metabolites:
|
Boars |
Zhang et al. (2023)Zhang Y, Yuan W, Liu Y, Liu Y, Liang H, Xu Q, Liu Z, Weng X. Plasma membrane lipid composition and metabolomics analysis of Yorkshire boar sperms with high and low resistance to cryopreservation. Theriogenology. 2023;206:28-39. http://doi.org/10.1016/j.theriogenology.2023.04.016. PMid:37178672. http://doi.org/10.1016/j.theriogenology....
|
Oleic acid, Oleamide, N8-acetylspermidine |
Metabolites:
|
Boars |
Torres et al. (2022)Torres MA, Pedrosa AC, Novais FJ, Alkmin DV, Cooper BR, Yasui GS, Fukumasu H, Machaty Z, Andrade AFCD. Metabolomic signature of spermatozoa established during holding time is responsible for differences in boar sperm†. Biol Reprod. 2022;106(1):213-26. http://doi.org/10.1093/biolre/ioab200. PMid:34725678. http://doi.org/10.1093/biolre/ioab200...
|
Inosine, Hypoxanthine, Creatine, ADP, Niacinamide, Spermine, 2-methylbutyrylcarnitine |
Metabolites:
|
Boars |
Sui et al. (2023)Sui H, Sheng M, Luo H, Liu G, Meng F, Cao Z, Zhang Y. Characterization of freezability-associated metabolites in boar semen. Theriogenology. 2023;196:88-96. http://doi.org/10.1016/j.theriogenology.2022.11.013. PMid:36401936. http://doi.org/10.1016/j.theriogenology....
|
L-citruline |
Transcripts:
|
Boars |
Fraser et al. (2020)Fraser L, Brym P, Pareek CS, Mogielnicka-brzozowska M, Paukszto Ł, Jastrze JP, Wasilewska-sakowska K, Ma A. Transcriptome analysis of boar spermatozoa with different freezability using RNA-Seq. Theriogenology. 2020;142:400-13. http://doi.org/10.1016/j.theriogenology.2019.11.001. PMid:31711689. http://doi.org/10.1016/j.theriogenology....
|
FOS, NFATC3, EAF2, BAMBI, PTPRU, PTPN2, ND6, ACADM, |
Fertility |
Proteins: Calmodulin, |
Bulls |
Soggiu et al. (2013)Soggiu A, Piras C, Hussein HA, De Canio M, Gaviraghi A, Galli A, Urbani A, Bonizzi L, Roncada P. Unravelling the bull fertility proteome. Mol Biosyst. 2013;9(6):1188-95. http://doi.org/10.1039/c3mb25494a. PMid:23392320. http://doi.org/10.1039/c3mb25494a...
|
ATP synthase mitochondrial subunits alpha and delta, Malate dehydrogenase and Sperm equatorial segment protein 1 |
Proteins:
|
Boars |
Kwon et al. (2015)Kwon W, Rahman S, Ryu D, Park Y, Pang M. Increased male fertility using fertility-related biomarkers. Sci Rep. 2015;5(1):15654. http://doi.org/10.1038/srep15654. PMid:26489431. http://doi.org/10.1038/srep15654...
|
Ras-related protein Rab-2A, Cytochrome b-c1 complex subunit 1, Cytochrome b-c1 complex subunit 2 |
Proteins: Acyl-CoA thioesterase 9, Albumin, Casein kinase 2, K voltage-gated channel shaker-related |
Bulls |
Peddinti et al. (2008)Peddinti D, Nanduri B, Kaya A, Feugang JM, Burgess SC, Memili E. Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility. BMC Syst Biol. 2008;2(1):19. http://doi.org/10.1186/1752-0509-2-19. PMid:18294385. http://doi.org/10.1186/1752-0509-2-19...
|
Proteins:
|
Bulls |
Zhang et al. (2021)Zhang H, Liu H, Kataoka S, Kinukawa M, Uchiyama K, Kambe J, Watanabe G, Jin W, Nagaoka K. L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls. Biol Reprod. 2021;104(5):1154-61. http://doi.org/10.1093/biolre/ioab024. PMid:33590844. http://doi.org/10.1093/biolre/ioab024...
|
L amino acid oxidase 1 |
Metabolites: |
Bulls |
Menezes et al. (2019)Menezes EB, Velho ALC, Santos F, Dinh T, Kaya A, Topper E, Moura AA, Memili E. Uncovering sperm metabolome to discover biomarkers for bull fertility. BMC Genomics. 2019;20(1):714. http://doi.org/10.1186/s12864-019-6074-6. PMid:31533629. http://doi.org/10.1186/s12864-019-6074-6...
|
Gamma-aminobutyric acid, Carbamate, Benzoic acid, Lactic acid, Palmitic acid |
Metabolites:
|
Bulls |
DasGupta et al. (2021)DasGupta MA, Kumaresan AA, Kishor Saraf KA, Karthikkeyan GB, Keshava Prasad BTS, Kumar Modi PB, Ramesha KC, Jeyakumar SC, Manimaran AC. Preliminary comparative deep metabolomic analysis of spermatozoa from zebu and crossbred cattle suggests associations between metabolites, sperm quality and fertility. Reprod Fertil Dev. 2021;33(6):427-36. http://doi.org/10.1071/RD20304. PMid:33775276. http://doi.org/10.1071/RD20304...
|
Taurine, Hypotaurine |
Transcripts:
|
Bulls |
Lalancette et al. (2008)Lalancette C, Thibault C, Bachand I, Caron N, Bissonnette N. Transcriptome analysis of bull semen with extreme nonreturn rate: use of suppression-subtractive hybridization to identify functional markers for fertility. Biol Reprod. 2008;78(4):618-35. http://doi.org/10.1095/biolreprod.106.059030. PMid:18003951. http://doi.org/10.1095/biolreprod.106.05...
|
rRNA genes (18S, 12S, and Large chain R) |
Mitochondrial activity |
Proteins: |
Stallions |
Gaitskell-Phillips et al. (2021b)Gaitskell-Phillips G, Martín-Cano FE, Ortiz-Rodríguez JM, Silva-Rodríguez A, Da Silva-Álvarez E, Rojo-Domínguez P, Tapia JA, Gil MC, Ortega-Ferrusola C, Peña FJ. Proteins involved in mitochondrial metabolic functions and fertilization predominate in stallions with better motility. J Proteomics. 2021b;247:104335. http://doi.org/10.1016/j.jprot.2021.104335. PMid:34298182. http://doi.org/10.1016/j.jprot.2021.1043...
|
Phosphoglycerate mutase, peroxiredoxin 6-like proteins, actin-1 analogue, transmembrane protein analogue |
Viability |
Chaperonin TCP1 subunit 8, Testis expressed 101 |
Stallions |
Motility |
Seminal plasma |
Proteins:
|
Bucks |
Jia et al. (2021)Jia B, Liang J, Lv C, Memon S, Fang Y, Wu G, Quan G. The characteristics of proteome and metabolome associated with contrasting sperm motility in goat seminal plasma. Sci Rep. 2021;11(1):15562. http://doi.org/10.1038/s41598-021-95138-9. PMid:34330982. http://doi.org/10.1038/s41598-021-95138-...
|
Zonadhesin, Superoxide dismutase, Sperm equatorial segment protein 1, Mitochondrial thioredoxin reductase, Zona pellucida binding protein, Aquaporin 7 |
Metabolites:
|
|
Thioetheramide-PC, Adenosine, N,N-Dimethylguanosine, Isocitric acid |
Transcripts:
|
Boars |
Zhao et al. (2024)Zhao Y, Qin J, Sun J, He J, Sun Y, Yuan R, Li Z. Motility-related microRNAs identified in pig seminal plasma exosomes by high-throughput small RNA sequencing. Theriogenology. 2024;215:351-60. http://doi.org/10.1016/j.theriogenology.2023.11.028. PMid:38150851. http://doi.org/10.1016/j.theriogenology....
|
miRNAs (ssc-miR- |
122–5p, ssc-miR-486, ssc-miR-451, ssc-miR-345–3p, ssc-miR-362, and ssc-miR-500–5p) |
Liquid preservation ability/Freezability |
Metabolites:
|
Bulls |
Pessoa et al. (2023)Pessoa ER, Roger Vasconcelos F, de Oliveira Paula‐Marinho S, de Menezes Daloso D, Damasceno Guerreiro D, Matias Martins JA, Gomes-Filho E, Alencar Moura A. Metabolomic profile of seminal plasma from Guzerá bulls (Bos indicus) with contrasting sperm freezability phenotypes. Reprod Domest Anim. 2023;58(10):1379-92. http://doi.org/10.1111/rda.14453. PMid:37592767. http://doi.org/10.1111/rda.14453...
|
Propanoic acid, D-ribose, glycine |
Metabolites:
|
Boars |
Song et al. (2023)Song C, Chang L, Wang B, Zhang Z, Wei Y, Dou Y, Qi K, Yang F, Li X, Li X, Wang K, Qiao R, Han X. Seminal plasma metabolomics analysis of differences in liquid preservation ability of boar sperm. J Anim Sci. 2023;101:skad392. http://doi.org/10.1093/jas/skad392. http://doi.org/10.1093/jas/skad392...
|
D-proline, Arginine, L-citruline, Phenylalanine, Leucine, DL-proline, DL-serine, Indole |
Metabolites:
|
Boars |
Sui et al. (2023)Sui H, Sheng M, Luo H, Liu G, Meng F, Cao Z, Zhang Y. Characterization of freezability-associated metabolites in boar semen. Theriogenology. 2023;196:88-96. http://doi.org/10.1016/j.theriogenology.2022.11.013. PMid:36401936. http://doi.org/10.1016/j.theriogenology....
|
Tryptophan |
Fertility |
Proteins:
|
Boars |
Zeng et al. (2021)Zeng F, Chen Y, Guo C, Li C, Wei H, Li L, Meng L, Zhang S. Analysis of differentially abundant proteins related to boar fertility in seminal plasma using iTRAQ-based quantitative proteomics. J Proteomics. 2021;236:104120. http://doi.org/10.1016/j.jprot.2021.104120. PMid:33540064. http://doi.org/10.1016/j.jprot.2021.1041...
|
Ceruloplasmin, Carboxypeptidase E, Serine protease inhibitor family A member 12 |