Flank |
To investigate the effects of aerobic exercise training starting at adolescence, on Walker 256 tumor growth and insulin secretion in adult rats |
8 x 107
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MOREIRA et al., 20181515.Moreira, VM, Franco CCS, Prates KV, Gomes RM, Moraes AMP, Ribeiro TA , et al. Aerobic Exercise Training Attenuates Tumor Growth and Reduces Insulin Secretion in Walker 256 Tumor-Bearing Rats. Front Physiol. 2018; 9: 465.
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To evaluate whether obese adult rats that were chronically treated with an antidiabetic drug, glibenclamide, exhibit resistance to rodent breast carcinoma growth |
8 x 107
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FRANCO et al., 20171616.Franco CCS, Previate C, de Barros Machado KG, Piovan S, Miranda RA, Prates KV, et al. Chronic Glibenclamide Treatment Attenuates Walker-256 Tumour Growth in Prediabetic Obese Rats. Cell Physiol Biochem. 2017; 42 (1): 81-90.
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To identify mechanisms of inflammatory response in atrophy in cancer cachexia |
2 x 107
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HENRIQUES et al., 20171717.Henriques FS, Sertié FAL, Franco FO, Knobl P, Neves RX, Andreotti S, et al. Early suppression of adipocyte lipid turnover induces immunometabolic modulation in cancer cachexia syndrome. FASEB J. 2017; 31 (5): 1976-1986.
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To investigate the antitumor activity of the soluble fraction of polysaccharides, extracted fromcabernet franc red wine, in Walker-256 tumor-bearing rats |
2 x 107
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STIPP et al., 20171010.Stipp MC, Bezerra IL, Corso CR, Livero FAR, Lomba LA, Caillot ARC, et al. Necroptosis mediates the antineoplastic effects of the soluble fractionof polysaccharide from red wine in Walker-256 tumor-bearing rats. Carbohydr Polym. 2017; 160: 123-133.
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To investigate the pioglitazone effects, isolated or associated with insulin, on insulin resistance, cachexia and metabolic disorders in cancer animal model |
8 x 107
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SILVA et al., 20171818.Silva FF, Ortiz-Silva M, Galia WBS, Cassolla P, Graciano MFR, Zaia CTBV, et al. Pioglitazone improves insulin sensitivity and reduces weight loss in Walker-256 tumor-bearing rats. Life Sci. 2017; 15: 68-74.
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To evaluate the in vivo antitumor effects and toxicity of a new Ru(II) compound, cis-(Ru[phen]2[ImH]2)2+ (also called RuphenImH [RuC]), against Walker-256 carcinosarcoma in rats |
1 x 107
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SOUZA et al., 20171414.Souza CEA, Alves de Souza HM, Stipp MC, Corso CR, Galindo CM, Cardoso CR, et al. Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats. Free Radic Biol Med. 2017; 110: 228-239.
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To analyse the modulatory effect of a leucine-rich diet on direct and indirect tumor-induced placental damage |
1 x 106
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CRUZ et al., 20161919.Cruz BLG, Silva PC, Tomasin R, Oliveira AG, Viana LR, Salomao EM, et al. Dietary leucine supplementation minimizes tumour-induced damage in placental tissues of pregnant, tumour-bearing rats. BMC. 2016; 16 (58): 1-13.
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To determine the effect of tumors on interstitial cells of Cajal in the rat jejunum and to investigate the effect of 2% L-glutamine on interstitial cells of Cajal and tumor-induced changes |
8 x 107
|
FRACARO et al, 20162020.Fracaro L, Frez FCV, Silva BC, Vicentini GE, de Souza SRG, Martins HÁ, et al. Walker 256 tumor-bearing rats demonstrate altered interstitial cells of cajal effects on icc in the walker 256 tumor model. Neurogastroenterol Motil. 2016; 28 (1): 101-115.
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To assess the effect of endostatin combined with a small dose of 32 P-colloidal in vivo
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1 x 106
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GAO et al., 201677.Gao H, Zhu J, Li Y, Fu P, Shen B. Inhibitory effect of endostatin gene therapy combined with phosphorus-32 colloid on tumour growth in Wistar rats. Biosci Rep. 2016; 36 (3): 1-7.
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To assess antioxidant effects of açaí seed extract on anorexia-cachexia induced by Walker-256 tumor |
1 x 107
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NASCIMENTO et al., 20162121.Nascimento VHN, Lima CS, Paixão JTC, Freitas JJS, Kietzer KS. Antioxidant effects of açaí seed (Euterpe oleracea) in anorexia-cachexia syndrome induced by Walker-256 tumor. Acta Cir Bras. 2016; 31 (9): 597-601.
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To provide insight into adipocyte involvement in inflammation along the progression of cachexia |
2 x 107
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NEVES et al., 20162222.Neves RX, Rosa-Neto JC, Yamashita AS, Matos-Neto EM, Riccardi DMR, Lira FS, et al. White adipose tissue cells and the progression of cachexia: inflammatory pathways. J Cachexia Sarcopenia Muscle. 2016; 7 (2): 193-203.
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To evaluate the metformin on Walker-256 tumor evolution and also on protein metabolism in gastrocnemius muscle and body composition |
1 x 106
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OLIVEIRA et al. 20162323.Oliveira AG, Gomes-Marcondes MCC. Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats. BMC. 2016; 16 (418): 1-10.
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To evaluate whether leucine supplementation ameliorates cachexia in the heart |
2,5 x 106
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TONETO et al., 20162424.Toneto AT, Ramos LAF, Salomão EM, Tomasin R, Aereas MA, Gomes-Marcondes MCC. Nutritional leucine supplementation attenuates cardiac failure in tumour-bearing cachectic animals. J Cachexia Sarcopenia Muscle. 2016; 7 (5): 577-586.
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To evaluate whether a leucine-rich diet affects metabolomic derangements in serum and tumor tissues in tumor-bearing Walker-256 rats |
2,5 x 106
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VIANA et al., 20162525.Viana LR, Canevarolo R, Luiz ACP, Soares RF, Lubaczeuski C, Zeri ACM, et al. Leucine-rich diet alters the 1H-NMR based metabolomic profile without changing the Walker-256 tumour mass in rats. BMC. 2016; 16 (1): 1-14.
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To evaluate the effect of dietary supplementation with 20 g/kg L-glutamine on the intrinsic innervation of the enteric nervous system in healthy and Walker 256 tumor-bearing Wistar rats during the development of experimental cachexia |
8 x 107
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VICENTINI et al., 20162626.Vicentini GE, Fracaro L, de Souza SRG, Martins HA, Guarnier FA, Zanoni JN. Experimental cancer cachexia changes neuron numbers and peptide levels in the intestine: partial protective effects after dietary supplementation with l-glutamine. Plos one. 2016; 16 (9): 1-23.
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To investigate the pharmacokinetics profiles of ginsenoside Rg and ginsenoside Rh after oral administration of pure ginsenoside Rg were administered, and compare the difference of the pharmacokinetics profiles between normal and Walker 256 tumorbearing rats |
1 x 10 |
FAN et al., 20162727.Fan H, Xiaoling S, Yaliu S, Mingming L, Xue F, Xiansheng M, Li F. Comparative pharmacokinetics of ginsenoside rg and ginsenoside rh after oral administration of ginsenoside rg in normal and walker 256 tumor bearing rats. Pharmacogn Mag. 2016; 12 (45): 21-24.
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To investigate the effect of fish oil supplementation on apoptosis protein expression in Walker 256 tumor bearing rats |
1 x 108
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BORGHETTI et al, 20152828.Borghetti G, Yamaguchi AA, Aikawa J, Yamazaki RK, Brito GAP, Fernandes LC. Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53, Bcl-2, caspase-7 and caspase-3 protein expression. Lipids Health Dis. 2015; 14 (94): 1-5.
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To evaluate the in vivo antitumor actions and toxicity of the dichloromethane fraction of Moquiniastrum polymorphum subsp. floccosum (formerly Gochnatia polymorpha ssp. floccosa), composed of sesquiterpene lactones, against Walker-256 carcinosarcoma in rats |
1 x 107
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MARTINS et al., 20151313.Martins GG, Lívero FAR. Stolf AM, Kopruszinski CM, Cardoso CC, Beltrame OC, et al. Sesquiterpene lactones of Moquiniastrum polymorphum subsp. Floccosum have antineoplastic effects in Walker-256 tumor-bearing rats. Chem Biol Interact. 2015; 228: 46-56.
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To investigate the effects of celecoxib and ibuprofen, both non-steroidal anti-inflammatory drugs, on the decreased gluconeogenesis observed in liver of Walker-256 tumor-bearing rats |
8 x 107
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SOUZA et al., 20152929.Souza CO, Kurautia MA, Silva FF, Morais H, Curi R, Hirabara SM, et al. Celecoxib and ibuprofen restore the ATP content and the gluconeogenesis activity in the liver of walker-256 tumor-bearing rats. Cell Physiol Biochem. 2015; 36 (4): 1659-1669.
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To investigate the effect of a leucine-rich diet on protein metabolism in the foetal gastrocnemius muscles of tumor-bearing pregnant rats |
2,5 x 105
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CRUZ et al., 20143030.Cruz B, Gomes-Marcondes MCC. Leucine-rich diet supplementation modulates foetal muscle protein metabolism impaired by Walker-256 tumour. Reprod Biol Endocrinol. 2014; 12 (2): 1-10.
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To test the effect of metformin on the tumor growth in rats with metabolic syndrome |
8 x 107
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FRANCO et al., 20143131.Franco CCS, Miranda RA, Oliveira JC, Barella LF, Agostinho AR, Prates KV, et al. Protective effect of metformin against walker 256 tumor growth is not dependent on metabolism improvement. Cell Physiol Biochem. 2014; 34 (6): 1920-1932.
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To investigate the effect of fish oil supplementation on tumor growth, cyclooxygenase 2, peroxisome proliferator-activated receptor gamma, and RelA gene and protein expression in Walker 256 tumor-bearing rats |
3 x 107
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BORGHETTI et al., 201344.Borghetti G, Yamazaki RK, Coelho I, Pequito DCT, Schiessel DL, Kryczyk M, et al. Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA. Braz J Med Biol Res. 2013; 46 (8): 696-699.
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To evaluate gluconeogenesis from alanine, pyruvate and glycerol, and related metabolic parameters in perfused liver from Walker-256 tumor-bearing rats on days 5, 8 and 12 of tumor development |
8 x 107
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MOREIRA et al., 20133232.Moreira CCL, Cassolla P, Dornellas APS, Morais H, Souza CO, Borba-Murad GR, et al. Changes in liver gluconeogenesis during the development of Walker-256 tumour in rats. Int. J. Exp. Path. 2013; 94 (1): 47-55.
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To investigate the effect of infliximab, an anti-tumor necrosis factor a monoclonal antibody, on the progression of cachexia and several metabolic parameters affected by the Walker-256 tumor in rats |
8 x 107
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MIKSZA et al., 20131212.Miksza DR, Souza CO, Morais H, Rocha AF, Borba-Murad GR, Bazotte RB, et al. Effect of infliximab on metabolic disorders induced by Walker-256 tumor in rats. Pharmacol Rep. 2013; 65 (4): 960-969.
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To describe effects of the resistance exercise training upon adipose tissue inflammation in cachexia |
3 x 107
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DONATTO et al., 20133333.Donatto FF, Neves RX, Rosa FO, Camargo RG, Ribeiro H, Matos-Neto EM, et al. Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats. Cytokine. 2013; 61 (2): 426-432.
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To describe set point of weight loss and how the different visceral adipose tissue depots contribute to this symptom |
2 x 107
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BATISTA JR et al., 20123434.Batista Jr ML, Neves RX, Peres SB, Yamashita AS, Shida CS, Farmer SR, et al. Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia. J Endocrinol. 2012; 215 (3): 363-373.
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Tibia |
To investigate the effects of electroacupuncture on mechanical allodynia and cellular immunity of cancer-induced bone pain rats, and to further explore the potential mechanism |
3 x 105
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LIANG et al., 20183535.Liang Y, Du JY, Fang JF, Fang RY, Zhou J, Shao XM, et al. Alleviating Mechanical Allodynia and Modulating Cellular Immunity Contribute to Electroacupuncture's Dual Effect on Bone Cancer Pain. Integr Cancer Ther. 2018; 17 (2): 401-410.
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To investigate the role of NF-κB in CIBP by regulating MCP-1/chemokine CC motif receptor-2 (CCR2) signaling pathway. |
1 x 106
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WANG et al., 20183636.Wang Y, Ni H, Li H, Deng H, Xu LS, Xu S, et al. Nuclear factor kappa B regulated monocyte chemoattractant protein-1/chemokine CC motif receptor-2 expressing in spinal cord contributes to the maintenance of cancer-induced bone pain in rats. Mol Pain. 2018; 14: 1-17.
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To investigate whether P2Y12R is involved in the establishment of cancer-induced bone pain model by inoculating Walker 256 breast cancer cells in the tibia and to examine the effect of P2Y12R antagonist on spinal neuroimmune activity in a cancer-induced bone pain model |
2 x 107
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LIU et al., 20173737.Liu M, Yao M, Wang H, Xu L, Zheng Y, Huang B, et al. P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain. J Pain Res. 2017; 10: 417-426.
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To investigate the role of Suppressor of cytokine signaling 3 in dorsal root ganglion in the development of cancer-induced pain |
4 x 105
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WEI et al., 20173838.Wei J, Li M, Wang D, Zhu H, Kong X, Wang S, et al. Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats. Mol Pain. 2017; 13: 1-12.
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To assess the antinociceptive effect of Tanshinone IIA on cancer-induced bone pain |
5 x 102
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HAO et al., 20163939.Hao W, Chen L, Wu L, Yang F, Niu J, Kaye AD, et al. Tanshinone IIA Exerts an Antinociceptive Effect in Rats with Cancer-induced Bone Pain. Pain Physician. 2016; 19 (7): 465-476
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To investigate whether spinal CCR5 and its downstream PKCγ pathway is involved in the maintenance of cancer-induced bone pain |
1 x 105
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HANG et al., 20164040.Hang LH, Li SN, Dan X, Shu WW, Luo H, Shao DH. Involvement of spinal CCR5/PKCΓ signaling pathway in the maintenance of cancer-induced bone pain. Neurochem Res. 2016; 42 (2): 563-571.
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To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on bone cancer pain in rats |
4 x 105
|
SONG et al., 201699.Song ZP, Xiong BR, Guan XH, Cao F, Manyande A, Zhou YQ, et al. Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes. Acta Pharmacol Sin. 2016; 37 (6): 753-762.
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To investigate whether the lysophosphatidic acid receptor 1 and Rho / ROCK signaling are involved in cancer-induced bone pain |
2 x 105
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PAN et al., 20164141.Pan R, Di H, Zhang J, Huang Z, Sun Y, Yu W, et al. Inducible lentivirus-mediated sirna against TLR4 reduces nociception in a rat model of bone cancer pain. Mediators Inflamm. 2016; 1: 1-7.
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Create a viable prolonged treatment for bone cancer pain |
5 x 105
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XU et al., 20154242.Xu JY, Jiang Y, Liu W, Huang YG. Calpain inhibitor reduces cancer‑induced bone pain possibly through inhibition of osteoclastogenesis in rat cancer‑induced bone pain model. Chin Med J. 2015; 128 (8): 1102-1107.
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To determine the efficacy of a calpain inhibitor on bone resorption and behavioral responses to pain in vivo in intratibial tumor injected cancer-induced bone pain rats |
1 x 105
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ZHU et al., 20154343.Zhu S, Wang C, Han Y, Song C, Hu X, Liu Y. Sigma-1 receptor antagonist bd1047 reduces mechanical allodynia in a rat model of bone cancer pain through the inhibition of spinal NR1 phosphorylation and microglia activation. Mediators Inflamm. 2015; 1: 1-11.
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Examine the potential of the spinal sigma-1 receptor in the development of cancer-induced bone pain |
2 x 105
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WU et al., 20164444.Wu JX, Yuan XM,Wang Q, Wei W, Xu MY. Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in modulating P2X3 receptor-mediated bone cancer pain in rats. Mol Pain. 2016; 12: 1-10.
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Examine the potential role of the spinal PKA/CREB signaling pathway in the development of bone cancer pain |
1 x 105
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HANG et al., 20134545.Hang LH, Yang JP, Shao DH, Chen Z, Wang H. Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain. Pharmacol Rep. 2013; 65 (3): 710-716.
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To investigate whether the chemokine receptor 5 and C-kinase receptor pathway is involved in the maintenance of cancer-induced bone pain |
1 x 105
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HANG et al., 2013b4646.Hang LH, Shao DH, Chen Z, Chen YF, Shu WW, Zhao ZG. Involvement of spinal cc chemokine ligand 5 in the development of bone cancer pain in rats. Basic Clin Pharmacol Toxicol. 2013; 113 (5): 325-328.
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To investigate the effects of intrathecal injection with lipoxin and related analogues on cancer-induced bone pain in rats |
1 x 108
|
HU et al., 20124747.Hu S, Ying QLM, Wang J, Wang ZF, Mi ZH, Wang XW, et al. Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines. J Neuroinflammation. 2012; 26 (9): 1-12.
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To investigate the role of c-jun N-terminal kinase pathway in the spinal cord in cancer-induced bone pain |
3,5 x 105
|
WANG et al., 20124848.Wang XW, Hu S, Ying QLM, Li Q, Yang CJ, Zhang H, et al. Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats. Mol Brain. 2012; 5 (21): 1-7.
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Femur |
To investigate the hypothesis that urinary levels of N telopeptide (NTx) can be used to predict the anti‑nociceptive responses of zoledronic acid and paclitaxel on bone metastases in a rat model |
1 x 105
|
GUI et al., 20154949.Gui Q, Xu C, Li D, Zhuang L, Xia S, Yu S. Urinary N telopeptide levels in predicting the anti-nociceptive responses of zoledronic acid and paclitaxel in a rat model of bone metastases. Mol Med Rep. 2015; 12 (3): 4243-4249.
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Compare the effects of ibandronate and paclitaxel on bone structure and its mechanical properties and biochemical turnover in resorption markers using an immunocompetent Walker 256-Sprague-Dawley model, which was subjected to tumor-induced osteolysis. |
2,5 x 106
|
CHUNG et al., 201555.Chung YS, Kang HC, Lee T. Comparative effects of ibandronate and paclitaxel on immunocompetent bone metastasis model. YMJ. 2015; 56 (6): 1643-1650.
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Establish a model of femoral bone cancer |
1 x 105
|
GUI et al., 20135050.Gui Q, Xu C, Zhuang L, Xia S, Chen Y, Peng P. et al. A new rat model of bone cancer pain produced by rat breast cancer cells implantation of the shaft of femur at the third trochanter level. Cancer Biol Ther. 2013; 14 (2): 193-199.
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Paw |
To investigate the effects of crotoxin on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous lipoxin A4 |
1 x 106
|
BRIGATTE et al., 201666.Brigatte P, Faiad OJ, Nocelli RCF, Landgraf RG, Palma MS, Cury Y, et al. Walker 256 tumor growth suppression by crotoxin involves formyl peptide receptors and lipoxin A4. Mediators Inflamm. 2016; 8: 1-11.
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