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Human and Animal Health • Braz. arch. biol. technol. 60 • 2017 • https://doi.org/10.1590/1678-4324-2017160368   copy

In Vitro Assessment of Antileishmanial Activity of Natamycin and Nystatin

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

The present study was aimed to evaluate the in vitro antileishmanial activity of four different concentrations of natamycin and nystatin by using MTT 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyl tetrazolium bromide reduction assay. In vitro antileishmanial activity revealed that the IC50 of natamycin (80.49 μg/ml) and nystatin (105.7 μg/ml) was less than that of sodium stibogluconate (127.9 μg/ml), and more than amphotericin B (18.91 μg/ml).

Key words:
Leishmaniasis; Leishmania donovani; Antileishmanial; Natamycin; Nystatin

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