Swapna et al.[2626 Swapna N, Vamsi UM, Usha G, Padma T. Risk conferred by FokI polymorphism of vitamin D receptor (VDR) gene for essential hypertension. Indian J Hum Genet. 2011 Sep;17(3):201-6.]/India/2011 |
35-60 |
CS=280; CT=200 |
-Duration of disease, BMI, cigarettes, alcohol, diabetes and lipid profile. |
-Association between Fok I and HP risk. |
Vaidya et al.[2727 Vaidya A, Sun B, Forman JP, Hopkins PN, Brown NJ, Kolatkar NS, et al. The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians. Clin Endocrinol (Oxf) [Internet]. 2011 Jun [cited 2019 May 11];74(6):783-90. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089671/. https://www.ncbi.nlm.nih.gov/pmc/article...
]/United States/2012 |
29-56 |
CS= 375; CT=146 |
-PRA and 25 (OH) D. |
-Fok I was associated with lower PRA. |
Glocke et al.[2828 Glocke M, Lang F, Schaeffeler E, Lang T, Schwab M, Lang UE. Impact of vitamin D receptor VDR rs2228570 polymorphism in oldest old. Kidney Blood Press Res. 2013 Sep;37(4-5):311-22.]/Germany/2013 |
>90 and <90 |
CS=101; CT=208 |
-Weight, height and BMI. |
-Potential influence of Fok I on DBP in men. |
Cottone et al.[2929 Cottone S, Guarino L, Arsena R, Scazzone C, Tornese F, Guarneri M, et al. Vitamin D receptor gene polymorphisms and plasma renin activity in essential hypertensive individuals. J Hum Hypertens. 2015 Aug;29(8):483-7.]/Italy/2014 |
18-75 |
CS=71; CT=72 |
-25 (OH) D, PRA, BMI, PTH, Ca2+, phosphorus, estimated glomerular filtration rate. |
-Higher DBP values in patients with ff genotype. |
Jia et al.[3030 Jia J, Shen C, Mao L, Yang K, Men C, Zhan Y. Vitamin D receptor genetic polymorphism is significantly associated with decreased risk of hypertension in a Chinese Han population. J Clin Hypertens (Greenwich). 2014 Sep;16(9):634-9.]/China/2014 |
47-72 |
CS=2.409; CT=3.063 |
-History of hypertension, diabetes, cigarettes, BMI, lipid profile and glucose. |
-Association between Fok I and AH in men. |
Errouagui et al.[3131 Errouagui A, Charoute H, Ghalim N, Barakat A, Kandil M, Rouba H. Relationship with vitamin D receptor (RVD) gene and essential arterial hypertension in Moroccan population. Int J Innov Appl Stud [Internet]. 2014 [cited 2019 Mar];8(2):556-66. Available from: http://www.ijias.issr-journals.org/abstract.php?article=IJIAS-14-216-12. http://www.ijias.issr-journals.org/abstr...
]/Morocco/2014 |
35-68 |
CS=177; CT=176 |
-FGP, lipid profile and 25 (OH) D. |
-Correlation between Fok I and AH susceptibility. |
Gussago et al.[3232 Gussago C, Arosio B, Guerini FR, Ferri E, Costa AS, Casati M, et al. Impact of vitamin D receptor polymorphisms in centenarians. Endocrine. 2016 Aug;53(2):558-64.]/Italy/2016 |
72-102 |
CS=102; CT=163 |
-Glucose, total cholesterol and uric acid. |
-Association between Fok I and AH polymorphism. |
Cross-sectional
|
Authors/Country/Year |
Age Group (y) |
SN |
Other variables |
Outcomes |
Ndiaye et al.[3333 Ndiaye NC, Said ES, Stathopoulou MG, Siest G, Tsai MY, Visvikis-Siest S. Epistatic study reveals two genetic interactions in blood pressure regulation. BMC Med Genet. 2013; 14(2):1-7.]/ France, Greece, Ireland, Portugal/2013 |
32-61 |
P1=1,912; P2=1,755 |
-BMI. |
-Association with systolic and diastolic pressure. |
Wang et al.[3434 Wang L, Chu A, Buring JE, Ridker PM, Chasman DI, Sesso HD. Common Genetic Variations in the Vitamin D Pathway in Relation to Blood Pressure. Am J Hypertens [Internet]. 2014 Nov [cited 2019 Feb 23];27(11):1387-95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24688000. http://www.ncbi.nlm.nih.gov/pubmed/24688...
]/United States/2014 |
47-62 |
W=23,294; I=69,395 |
-Pulse pressure. |
- No association between Fok I and AH. |
Cohort
|
Authors/Country/Year |
Age Group (y) |
SN |
Other variables |
Outcomes |
Wang et al.[3535 Wang L, Ma J, Manson JE, Buring JE, Gaziano JM, Sesso HD. A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr. 2013 Oct;52(7):1771-9.]/United States/2013 |
49-66 |
885 |
-Cigarette, alcohol, exercise, multivitamin, BMI, diabetes and hypercholesterolemia.-25 (OH) D and 1,25 (OH) 2 D 3. |
-Association between Fok I and AH risk. |