Intraosseous schwannoma of mandibular symphysis: case report

Intraosseous schwannoma of mandibular symphysis: case report

Suzie Aparecida de Lacerda^I; Luiz Guilherme Brentegani^I; Adalberto Luiz Rosa^II; Marcelo Vinícius Oliveira Vespúcio^I; Luiz Antônio Salata^II

^IDepartment of Morphology, Stomatology and Physiology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

^IIDepartment of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto, SP, Brazil

^{Correspondence}

ABSTRACT

Schwannoma (neurilemmoma) is a benign neoplasm originated from the neural sheath and occurring most frequently in the head and neck. Intraosseous schwannomas are rare. The mandible is the most common site of occurrence for these lesions. This article reports the case of an intraosseous schwannoma located in the mandibular symphysis of an 11-year-old boy. The lesion was surgically removed and no radiographic evidence of recurrence was observed after 5 years.

Key words: intraosseous schwannoma, neurilemmoma, mandibular symphysis.

RESUMO

O schwannoma (neurilemoma) é um neoplasma benigno que se origina da bainha neural e ocorre mais freqüentemente na cabeça e pescoço. Schwannomas intra-ósseos são raros. O local mais comumente afetado é a mandíbula. Este artigo documenta um caso de schwannoma intra-ósseo localizado na sínfise mandibular de um menino com 11 anos de idade. A lesão foi removida cirurgicamente e não houve evidências radiográficas de recorrência após 5 anos de acompanhamento.

INTRODUCTION

Schwannoma is a benign neoplasm of neuroectodermal derivation that originates from the Schwann cells (cells that cover peripheral nerves) (1-4). This painless slow-growth lesion may develop at any age and is most frequently located in the soft tissues of the head and neck (3,5).

Intraoral schwannomas are rare, representing less than 1% of the benign primary bone tumors (6). The most common site of occurrence is the mandible (7,8). Intraosseous schwannoma of the mandibular symphysis is exceptionally rare (9).

This article reports the case of an intraosseous schwannoma located in the mandibular symphysis of a child. The treatment approach is described and findings in the literature are discussed.

CASE REPORT

An 11-year-old boy presented with a slow-growth swelling in the mentum with approximately 3 years of evolution. The patient was symptom free and reported no history of pain and paresthesia. A clinical examination revealed that the area was swollen, round, singular and hard, with no bleeding or cortical plate perforation and was lined with normal mucosa. The permanent mandibular incisors were mispositioned, which was hindering occlusion. The primary incisors were present and the mucosa was intact.

Full radiographic examination showed a radiolucent unilocular intraosseous lesion with well-delimited borders and no signs of invasion. The lesion apparently was precluding the eruption of the permanent mandibular incisors, canine and premolar and causing root divergence (Fig. 1), expansion of the buccal and lingual cortical plates (Fig. 2) and discrete resorption of the roots of the primary teeth in contact with mass (Fig. 3). Agenesia of the central permanent incisors was also observed (there was not history of extraction of these teeth).

Under local anesthesia, a buccal mucoperiosteal flap was elevated and a bone window was made to gain access to the tumor. Because of its soft consistency, the tumor could not be removed in toto, and thus lesion remnants were carefully curetted . There were not signs of bone invasion. After adequate hemostasis was obtained, the flap was repositioned with 3-0 silk suture.

Histopathologic examination showed neoplastic connective tissue arranged in short fascicles, composed of cells with aligned long nuclei, similar to Schwann cells. Some of these nuclei formed typical palisades around an acellular eosinophilic area (Verocay bodies) (Fig. 4). Antoni A tissue was the predominant microscopic pattern, alternating with Antoni B areas occasionally. No signs of hemorrhage, necrosis, calcification or hyalinization were observed. Although some nuclear atypia could be noticed, typical and atypical mitotic activity was absent. The histopathologic diagnosis was intraosseous schwannoma.

The patient tolerated the surgical procedure well and the postoperative course was uneventful and uncomplicated. One month postoperatively, radiographs indicated the beginning of bone repair. The patient's profile was less voluminous than before surgery. Five years postoperatively, the radiographic appearance and clinical profile were normal (Figs. 5 and 6).

DISCUSSION

Schwannoma rarely occurs in the oral cavity. Intraosseous schwannomas are rare (less than 1%) (1,6), but when they occur, the mandible is the most commonly affected site (7,8). Most cases reported in the mandible had a more posterior location, corresponding to the intraosseous course of the inferior alveolar nerve (10,11).

In the case presented in this paper, the schwannoma was probably associated with the peripheral nervous plexus of the anterior region of the mandible. In 39 cases of intraosseous schwannoma of the mandible reviewed by Chi et al. (9), 28 were localized on the posterior body/ascending ramus region and 11 involved the anterior body, but only three cases affecting the symphysis. The present case is somewhat unusual because of its anterior location (mandibular symphysis).

There are 3 mechanisms by which schwannomas may involve bone: 1) a tumor may arise centrally within the bone, 2) a tumor may arise within the nutrient canal and produce canal enlargement, or 3) a soft tissue or periosteal tumor may cause secondary erosion and penetration into bone (12). In case we hereby report, the third mechanism can be excluded because there was no cortical bone perforation.

The clinical presentation of this case was a painless swelling tumor in the region of mandibular symphysis in a boy on the second decade of life. The radiographic appearance of a well-defined unilocular nonspecific radiolucent lesion, with root divergence (expansive growth) and root resorption only in teeth contacting the lesion, therefore suggestive of a benign process, had a difficult preoperative diagnosis. The possibility of intraosseous schwannoma was not considered at first because of the extreme rarity of this location. The histopathologic examination provided a definitive diagnosis for the case.

The microscopic aspect was characteristic and easily distinguishable from other lesions. There are two types of tissue arrangement: Antoni-A and Antoni-B. Alternation between Antoni A and B regions is common. Antoni-A type is composed of aligned fusiform cells, forming a typical palisade. Between the fibrils there are small eosinophilic masses called Verocay bodies. Antoni-B type is composed of a smaller number of cells and the spindle cells are randomly arranged within a loose myxomatous stroma (1,13). In this case, Antoni A tissue was the predominant microscopic pattern.

Because it is a well-encapsulated lesion, the treatment of choice for schwannomas is the conservative surgical enucleation with periodic follow-up. Recurrence is uncommon. In the present case, the patient has been followed up for five years with no clinical or radiographic signs of lesion recurrence. The slow (3 years) and expansive growth (root divergence was more accentuated than resorption), the well-delimited borders, the encapsulation and the lack of invasion signs, significant atypia, necrosis and recurrence after 5 years suggest benignity from both clinical and histopathological standpoints.

As diagnostic tools, ultrasonography, computed tomography and magnetic resonance imaging may be helpful for estimation of tumor margins as well as infiltration of surrounding structures. Nevertheless, they should not be considered as routine or indispensable procedures (1).

Accepted May 7, 2005

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Publication Dates

• Publication in this collection
  21 Dec 2006
• Date of issue
  2006

History

• Accepted
  07 May 2005
• Received
  07 May 2005