Asha 20122929 Asha, V. A comparative study between epidural ropivacaine with magnesium sulphate and ropivacaine for lower limb surgeries 2012 at http://repository-tnmgrmu.ac.in/7345/. http://repository-tnmgrmu.ac.in/7345/...
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Lower limb surgeries |
Epidural |
Ropivacaine |
16 mL 0.75% |
50 mg |
|
Before surgery |
Epidural 9 mL of 0.25% ropivacaine bolus |
TFAR, adverse effects |
Daabis 20133030 Daabiss MA, Kandil A. Evaluation of the effect of magnesium vs. midazolam as adjunct to epidural bupivacaine in patients undergoing total knee replacement. BJMP. 2013;6:a610.
|
40 |
40 |
Placebo (0.9% saline) |
Bolus + infusion |
English |
Knee replacement |
Epidural |
Bupivacaine |
1 mL 0.5% per segment |
50 mg |
MgSO4: 10 mg.h−1
|
During the surgery |
Epidural fentanyl 2 µg.mL−1+ LA 0.08% bolus |
Analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects, |
Elsharkawy 20183131 Elsharkawy RA, Farahat TE, Abdelhafez MS. Analgesic effect of adding magnesium sulfate to epidural levobupivacaine in patients with pre-eclampsia undergoing elective cesarean section. J Anaesthesiol Clin Pharmacol. 2018;34:328-34.
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Cesarean section |
Epidural |
Levobupivacaine |
20 mL 0.5% |
500 mg |
|
Before surgery |
diclofenac 75 mg VO or fentanyl 0.5 1 µg.kg−1 IV bolus |
TFAR, analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Farouk 2008a3232 Farouk S. Pre-incisional epidural magnesium provides pre-emptive and preventive analgesia in patients undergoing abdominal hysterectomy. Br J Anaesth. 2008;101:694-9.
|
29 |
29 |
Placebo (0.9% saline infusion before anesthesia induction until the end of the surgery) |
Bolus before induction of anesthesia + intraoperative infusion |
English |
Hysterectomy |
General |
Bupivacaine |
None |
50 mg |
10 mg.h−1
|
During surgery |
Epidural lidocaine bolus on demand |
Analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Farouk 2008b3232 Farouk S. Pre-incisional epidural magnesium provides pre-emptive and preventive analgesia in patients undergoing abdominal hysterectomy. Br J Anaesth. 2008;101:694-9.
|
29 |
29 |
Placebo (0.9% saline infusion before anesthesia induction until the end of the surgery) |
Bolus at the end of the surgery + infusion |
English |
Hysterectomy |
General |
Bupivacaine |
None |
50 mg |
|
During surgery |
Epidural lidocaine bolus on demand |
Analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Ghatak 20103333 Ghatak T, Chandra G, Malik A, et al. Evaluation of the effect of magnesium sulphate vs. clonidine as adjunct to epidural bupivacaine. Indian J Anaesth. 2010;54:308-13.
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Lower abdominal and lower limb surgeries |
Epidural |
Bupivacaine |
19 mL 0.5% |
50 mg |
|
Before surgery |
Epidural bupivacaine 0.25% 8 mL bolus |
TFAR, analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Gupta 20133434 Gupta A, Goyal V, Gupta N, et al. A randomized controlled trial to evaluate the effect of addition of a single dose of epidural magnesium sulphate on the duration of postoperative analgesia in patients undergoing lower abdominal surgeries under epidural anaesthesia. Sri Lankan J Anaesthesiol. 2013;21:27-31.
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Hysterectomy |
Epidural |
Bupivacaine |
9 mL 0.125% |
50 mg |
|
End of surgery |
Epidural fentanyl 1 µg.kg−1 bolus |
TFAR, 24h analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Kandil 20124444 Kandil AH, Hammad RAEA, Shafei MAE, et al. Preemptive use of epidural magnesium sulphate to reduce narcotic requirements in orthopedic surgery. Egypt J Anaesth. 2012;28:17-22.
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Lower limb surgery |
Epidural |
Bupivacaine |
0.5% 1 mL per segment |
50 mg |
10 mg.h−1
|
During surgery |
PCEA fentanyl + LA+ pethidine IM |
24h analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Lakra 20153535 Lakra AM, Shah P (Jain), Sundrani O, et al. Magnesium sulphate vs clonidine as an adjuvant to 0.5% bupivacaine in epidural anaesthesia for patients undergoing lower limb surgeries: a comparative study. J Evol Med Dent Sci. 2015;4:12680-90.
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Lower limb surgeries |
Epidural |
Bupivacaine |
19 mL 0.5% |
50 mg |
|
Before surgery |
|
PO adverse effects |
Lenin 20123636 Lenin P, Elango P, Sivakumar G, et al. Comparison of epidural bupivacaine and bupivacaine-magnesium sulphate combination in lower abdominal surgeries. J Evol Med Dent Sci2017;6:4925-9.
|
25 |
25 |
Placebo (0.9% saline) |
Bolus |
English |
Lower abdominal surgeries |
Epidural |
Bupivacaine |
19 mL 0.5% |
50 mg |
|
Before surgery |
|
TFAR |
Mohamad 20153737 Mohammad W, Mir SA, Mohammad K, et al. A randomized double-blind study to evaluate efficacy and safety of epidural magnesium sulfate and clonidine as adjuvants to bupivacaine for postthoracotomy pain relief. Anesth Essays Res. 2015;9:15-20.
|
20 |
20 |
Placebo (0.9% saline) |
Bolus |
English |
Thoracotomy |
Epidural + general |
Bupivacaine |
8 mL 0.25% |
50 mg |
|
End of surgery |
i.v. tramadol 50 mg |
TFAR, analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Munshi 20163838 Munshi B, Munshi A. Comparison of effects of magnesium sulphate v/s clonidine as an adjuvant to epidural bupivacaine in lower abdominal and lower limb surgeries. Natl J Med Res. 2016;6:284-7.
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Lower abdominal surgeries and lower limb surgeries |
Epidural |
Bupivacaine |
19 mL 0.5% |
50 mg |
|
Before surgery |
Epidural tramadol 50 mg bolus |
TFAR, PO adverse effects |
Omar 20183939 Omar H. Magnesium sulfate as a preemptive adjuvant to levobupivacaine for postoperative analgesia in lower abdominal and pelvic surgeries under epidural anesthesia (randomized controlled trial). Anesth Essays Res. 2018;12:256-61.
|
50 |
50 |
Placebo (0.9% saline) |
Bolus + epidural infusion levobupivacaine + magnesium infusion 5 mL.h−1 until the end of the surgery |
English |
Lower abdominal and pelvic surgeries |
Epidural + general |
Levobupivacaine |
14 mL 0.5% |
50 mg |
15 mg.h−1
|
during surgery |
i.v. pethidine 1 mg.kg−1+ paracetamol 1g |
TFAR, VAS pain scores, PO adverse effects |
Radwan 20174343 Radwan T, Awad M, Fahmy R, et al. Evaluation of analgesia by epidural magnesium sulphate versus fentanyl as adjuvant to levobupivacaine in geriatric spine surgeries. Randomized controlled study. Egypt J Anaesth. 2017;33:357-63.
|
22 |
22 |
Placebo (0.9% saline) |
Bolus + infusion |
English |
Spine surgeries |
Epidural + general |
Levo-bupivacaine |
14 mL 0.5% |
50 mg |
10 mg.h−1 (LA 0.125%+ MgSO4 2 mg.mL−1. 5 mL.h−1) |
During surgery |
Para-cetamol 1g i.v. / 50 mg pethidine i.v. |
Analgesic consumption (24 PO hours, VAS pain scores, PO adverse effects |
Rekha 20204040 Rekha P.A Comparative study between epidural plain ropivacaine and ropivacaine with magnesium sulfate for elective lower limb surgeries. J Med Sci Clin Res. 2020;08:262/72.
|
30 |
30 |
Placebo (0.9% saline) |
Bolus |
English |
Lower limb surgeries |
Epidural |
Ropivacaine |
16 mL 0.75% |
50 mg |
|
Before surgery |
Epidural ropivacaine bolus |
TFAR, analgesic consumption (24 PO hours), PO adverse effects |
Roy 20154141 Roy S, Mrunalini M, Sowmya Sri A.A prospective, double blind randomized controlled study comparing the effects of magnesium sulphate versus clonidine as an adjunct to bupivicaine in sub umbilical surgeries. J Evol Med Dent Sci. 2015;4:9358-69.
|
30 |
30 |
Placebo (0.9% saline) |
Bbolus |
English |
Infra-umbilical surgeries |
Epidural |
Bupivacaine |
19 mL 0.5% |
50 mg |
|
Before surgery |
Epidural bupivacaine 0.5% bolus |
TFAR, VAS pain scores, PO adverse effects |
Shahi 20144242 Shahi V, Verma A, Agarwal A, et al. A comparative study of magnesium sulfate vs dexmedetomidine as an adjunct to epidural bupivacaine. J Anaesthesiol Clin Pharmacol. 2014;30:538.
|
40 |
40 |
Placebo (0.9% saline) |
Bolus |
English |
Lower limb surgeries |
Epidural |
Bupivacaine |
14 mL 0.5% |
50 mg |
|
before surgery |
Epidural bupivacaine 12 mL 0.125% bolus |
TFAR, analgesic consumption (24 PO hours), VAS pain scores, PO adverse effects |
Sun 2012 4545 Sun J, Wu X, Xu X, et al. A comparison of epidural magnesium and/or morphine with bupivacaine for postoperative analgesia after cesarean section. Int J Obstet Anesth. 2012;21:310-6.
|
50 |
50 |
Placebo (0.9% saline) |
Bolus |
English |
Cesarean section |
CSEA |
Bupivacaine |
10 mL 0.1% |
500 mg |
|
During surgery |
Epidural 8 mL LA 0.1% bolus + FTN 1 µg.mL−1+ MgSO4 1 mg.mL−1
|
TFAR, analgesic consumption (24 PO hours, VAS pain scores, PO adverse effects |