Auroy Y et al.3232 Auroy Y, Benhamou D, Bargues L. Major complications of regional anesthesia in France: The SOS regional anesthesia hotline service. Anesthesiology. 2002;97:1274–80. (2002) |
1998–1999 |
France |
Yes |
Prospective |
79,979 |
Interscalene block (3,459) |
Peripheral neuropathy |
2.9/10,000 |
Supraclavicular block (1,899) |
Seizures |
5.3/10,000 |
Axillary plexus block (11,024) |
Seizures |
0.9/10,000 |
Peripheral neuropathy |
1.8/10,000 |
Midhumeral block (7,402) |
Seizures |
1.4/10,000 |
Peripheral neuropathy |
1.4/10,000 |
158,083 |
Overall regional blocks |
Severe neurologic complications |
0.35/10,000 |
Barrington MJ et al.3333 Barrington MJ, Watts SA, Gledhill S. Preliminary results of the australasian regional anaesthesia collaboration. Reg Anesth Pain Med. 2009;34:534–41. (2009) |
2006–2008 |
Australia |
Yes |
Prospective |
6,069 |
Overall |
Block-related nerve injury |
4/10,000 |
Systemic local anesthetic toxicity |
9.8/10,000 |
Belavic M et al.3434 Belavic M, Loncaric-Katusin M, Zunic J. Reducing the incidence of adverse events in anesthesia practice. Periodicum Biologorum. 2013;115:145–8. (2013) |
2012 |
Croatia |
No |
Prospective |
143 |
Overall |
Block-related nerve injury |
5/10,000 |
Capdevila X et al.3535 Capdevila X, Pirat P, Bringuier S, et al. Continuous peripheral nerve blocks in hospital wards after orthopedic surgery: a multicenter prospective analysis of the quality of postoperative analgesia and complications in 1,416 patients. Anesthesiology. 2005;103:1035–45. (2005) |
2000 |
France |
Yes (8 university hospitals) |
Prospective |
1’416 |
Orthopedic surgery /Femoral |
Nerve lesions |
44/10,000 |
Abscess |
15/10,000 |
Orthopedic surgery/Interscalene |
Acute respiratory failure |
78/10,000 |
Orthopedic surgery/Interscalene |
Laryngeal and recurrent laryngeal nerve paralysis |
78/10,000 |
Orthopedic surgery/PCB |
Severe hypotension |
1,500/10,000 |
Orthopedic surgery/Distal |
Systemic local anesthetic toxicity |
263/10,000 |
Orthopedic surgery/Axillary |
Seizure |
79/10,000 |
Huo T et al.3636 Huo T, Sun L, Min S, et al. Major complications of regional anesthesia in 11 teaching hospitals of China: a prospective survey of 106,569 cases. J Clin Anesth. 2016;31:154–61. (2016) |
2009–2011 |
China |
Yes (11 teaching hospitals) |
Prospective |
106,596 |
Overall |
Major regional anesthesia complications |
3.47/10,000 |
Orthopedics surgery (n = 31,097) |
Horner syndrome (n = 5), Seizure (n = 1), Hematoma (n = 1) |
2.3/10,000 |
Urology surgery (n = 16,769) |
Seizure (n = 1), Paraplegia (n = 1) |
1.2/10,000 |
General surgery (n = 17,907) |
Horner syndrome (n = 4), Recurrent laryngeal nerve block (n = 5), Extensive neuraxial block (n = 5), Seizure (n = 3), Cauda equina syndrome (n = 1), Hematoma (n = 1), Cardiac arrest (n = 1) |
11.2/10,000 |
Vascular surgery (n = 1,246) |
Recurrent laryngeal nerve block (n = 1) |
8.0/10,000 |
Plastic surgery (n = 1,579) |
Extensive neuraxial block (n = 3) |
19/10,000 |
Saied NN et al.3737 Saied NN, Helwani MA, Weavind LM, Shi Y, Shotwell MS, Pandharipande PP. Effect of anaesthesia type on postoperative mortality and morbidities: a matched analysis of the NSQIP database. Br J Anaesth. 2017;118:105–11. (2017) |
2005–2011 |
USA |
Yes (300 community and academicals centers) |
Retrospective |
64,119 |
General surgery, vascular surgery, orthopedic surgery and genitourinary surgery |
Peripheral nerve injury |
4/10,000 |
Intraoperative c-reactive protein or death |
4/10,000 |
Whiting PS et al.3838 Whiting PS, Molina CS, Greenberg SE, Thakore RV, Obremskey WT, Sethi M. Regional anaesthesia for hip fracture surgery is associated with significantly more peri-operative complications compared with general anaesthesia. Int Orthop. 2015;39:1321–7. (2015) |
2005–2011 |
USA, Saudi Arabia, Canada, Lebanon, United Kingdom, United Arab Emirates |
Yes (462 hospitals in USA and 34 in the other countries) |
Prospective |
7,764 |
Hip fracture surgery (111 of PNB within the original ample) |
Minor complications (wound dehiscence, superficial wound infection, pneumonia, and urinary tract infection) |
721/10,000 |
Major complication (deep wound infection, organ space infection, myocardial infarction, pulmonary embolism, deep venous thrombosis, cerebrovascular accident, postoperative neurological deficit, sepsis, septic shock, coma, and death within 30 postoperative days) |
810/10,000 |
Overall complications |
126/10,000 |