Kim 20132424 Kim SY, Kim JM, Lee JH, et al. Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery. Br J Anaesth. 2013;111:222-8.
|
DEX 0.4 mcg.kg-1.h-1
|
50 |
20-58 |
Nose surgery |
Saline |
50 |
|
|
Ham 20142525 Ham SY, Kim JE, Park C, et al. Dexmedetomidine does not reduce emergence agitation in adults following orthognathic surgery. Acta Anaesthesiol Scand. 2014;58:955-60.
|
DEX 0.1 mcg.kg-1
|
34 |
20-45 |
Orthognathic surgery |
Saline |
36 |
|
|
Kim 20151515 Kim DJ, Kim SH, So KY, et al. Effects of dexmedetomidine on smooth emergence from anaesthesia in elderly patients undergoing orthopaedic surgery. BMC Anesthesiol. 2015;15:139.
|
DEX 0.4 mcg.kg-1.h-1
|
57 |
≥65 |
Orthopedic surgery |
Saline |
58 |
|
|
Yang 20152626 Yang X, Li Z, Gao C, et al. Effect of dexmedetomidine on preventing agitation and delirium after microvascular free flap surgery: a randomized, double-blind, control study. J Oral Maxillofac Surg. 2015;73:1065-72.
|
DEX 0.5 mcg.kg-1.h-1 and 0.2-0.7 mcg.kg-1.h-1
|
39 |
18-80 |
Oral and maxillofacial surgery |
Saline |
40 |
|
|
Ding 20152727 Ding L, Zhang H, Mi W, et al. Effects of dexmedetomidine on anesthesia recovery period and postoperative cognitive function of patients after robot-assisted laparoscopic radical cystectomy. Int J Clin Exp Med. 2015;8:11388-95.
|
DEX 0.8 mcg.kg-1.h-1
|
20 |
45-80 |
Cystectomy |
Saline |
20 |
|
|
Liu 20161616 Liu Y, Ma L, Gao M, et al. Dexmedetomidine reduces postoperative delirium after joint replacement in elderly patients with mild cognitive impairment. Aging Clin Exp Res. 2016;28:729-36.
|
DEX 0.2-0.4 mcg.kg-1.h-1
|
100 |
65-80 |
Orthopedic surgery |
Saline |
100 |
|
|
Li 20162828 Li Y, Wang B, Zhang LL, et al. Dexmedetomidine combined with general anesthesia provides similar intraoperative stress response reduction when compared with a combined general and epidural anesthetic technique. Anesth Analg. 2016;122:1202-10.
|
DEX 0.6 mcg.kg-1.h-1
|
30 |
18-65 |
Open gastrectomy |
Saline |
30 |
|
|
Lee 20162929 Lee SH, Lee CY, Lee JG, et al. Intraoperative dexmedetomidine improves the quality of recovery and postoperative pulmonary function in patients undergoing video-assisted thoracoscopic surgery: a CONSORT-prospective, randomized, controlled trial. Medicine. 2016;95:e2854.
|
DEX 0.1 mcg.kg-1.h-1
|
50 |
≥20 |
Thoracoscopy |
Saline |
50 |
|
|
Kwon 20161414 Kwon SY, Joo JD, Cheon GY, et al. Effects of dexmedetomidine infusion on the recovery profiles of patients undergoing transurethral resection. J Korean Med Sci. 2016;31:125-30.
|
DEX 0.5 mcg and 0.5 mcg.kg-1.h-1
|
30 |
30-80 |
Transurethral resection of the prostate |
Saline |
30 |
|
|
Moshiri 20163030 Moshiri E, Modir H, Bagheri N, et al. Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy. Ann Card Anaesth. 2016;19:263-8.
|
DEX 0.5 mcg.kg-1.h-1
|
25 |
18-50 |
Electroconvulsive therapy |
Saline |
25 |
|
|
Song 20163131 Song J, Ji Q, Sun Q, et al. The opioid-sparing effect of intraoperative dexmedetomidine infusion after craniotomy. J Neurosurg Anesthesiol. 2016;28:14-20.
|
DEX 0.5 mcg.kg-1.h-1
|
25 |
18-60 |
Craniotomy |
Saline |
27 |
|
|
Deiner 20173232 Deiner S, Luo X, Lin HM, et al. Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial. JAMA Surg. 2017;152:e171505.
|
DEX 0.5 mcg.kg-1.h-1
|
189 |
≥68 |
Non-cardiac elective surgery |
Saline |
201 |
|
|
Lee 20183333 Lee C, Lee CH, Lee G, et al. The effect of the timing and dose of dexmedetomidine on postoperative delirium in elderly patients after laparoscopic major non-cardiac surgery: a double blind randomized controlled study. J Clin Anesth. 2018;47:27-32.
|
DEX 0.1 mcg.kg-1 and 0.2-0.7 mcg.kg-1.h-1
|
95 |
≥65 |
Non-cardiac surgery |
Saline |
109 |
|
|
Tang 20183434 Tang C, Juan L, Zhe-tao Z, et al. Neuroprotective effect of bispectral index-guided fast-track anesthesia using sevoflurane combined with dexmedetomidine for intracranial aneurysm embolization. Neural Regen Res. 2018;13:280-8.
|
DEX 0.1 mcg.kg-1 and 0.3 mcg.kg-1.h-1
|
54 |
18-70 |
Neurosurgery |
Saline |
52 |
|
|
Sun 20193535 Sun Y, Jiang M, Ji Y, et al. Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial. Drug Des Dev Ther. 2019;13:2911-22.
|
DEX 0.1 mcg.kg-1.h-1
|
281 |
≥65 |
Non-cardiac surgery |
Saline |
276 |
|
|
Total |
|
2,183 |
|
|